Mersin Üniversitesi Kardiyoloji Kliniğinde Kalp Yetersizliği ile Takip Edilen Hastalarda Anemi Sıklığı: Pilot Çalışma

Giriş: Anemi kalp yetersizliği (KY) olan hastalarda sık görülen bir komorbiditedir ve kötü fonksiyonel kapasite, artmış mortalite ve morbidite oranları ile ilişkili olduğu gösterilmiştir. Yaşlanan nüfusla birlikte KY olan hastalarda artış görülmektedir. Bu çalışmada kliniğimizde takip etmekte olduğumuz KY hastalarında anemi oranının saptanması amaçlanmış ve nedenleri tartışılmaya çalışılmıştır. Yöntem: Ocak 2018 ile Haziran 2018 arasındaki 6 aylık sürede kardiyoloji polikliniğine başvurmuş hastalar geriye dönük olarak taranmış ve KY olan hastaların hemogram, biyokimya, transferrin saturasyonu (TSAT) ve ferritin değerleri kayıt edilmiştir. Bulgular: Retrospektif olarak taranan 221 hastanın 114’ünde (%51.6) anemi olduğu saptandı. Bu anemik hastaların cinsiyet dağılımlarına bakıldığında % 53’ünün erkek, % 48.6’sının ise kadın olduğu görüldü. Kronik böbrek hastalığı (KBH) bulunanların istatistiksel olarak anlamlı olacak şekilde daha fazla anemiye sahip oldukları saptandı (p= 0.003). Ferritin ve B12 değerleri açısından iki grup arasında anlamlı bir fark görülmedi (p>0.05). TSAT açısından değerlendirildiğinde anemisi bulunan hastalarda bu değerin anlamlı olarak daha düşük olduğu saptandı (p

The Frequency of Anemia in Heart Failure Patients Followed in The Cardiology Clinic of Mersin University: Plot study

Introduction: Anemia is a common comorbidity in patients with heart failure (HF) and it is associated with poor functional capacity, increased mortality and morbidity rates. Because of aging population, the number of patients with HF is increasing. In this study, it is aimed that determine to frequency of anemia in patient with HF following in our clinic. Methods: Patients admitted to cardiology clinic for 6 months between January-June 2018 was screened retrospectively and hemogram, biochemistry, transferrin saturation (TSAT) and ferritin values of patients with HF were recorded. Results: Anemia was detected in 114 (51.6%) of 221 retrospectively screened patients. When analyzed to gender distributions of these patients, 53% were male, 48.6% were female. Number of anemic patients was statistically higher than number of non-anemic patients in the group of chronic kidney disease (p=0.003). Levels of ferritin and vitamin B12 were not significantly different between two groups (p> 0.05). When evaluated in terms of TSAT, this value was found to be significantly lower in patients with anemia (p

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1. Ambrosy AP, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. J Am Coll Cardiol. 2014 Apr 1;63(12):1123-33.
2. Mozaffarian D, et al. Heart Disease and Stroke Statistics-2016 Update: A Report from the American Heart Association. Circulation. 2016 Jan 26;133(4):e38-360.
3. Degertekin M, et al. Heart failure prevalence and predictors in Turkey: HAPPY study. Turk Kardiyol Dern Ars. 2012 Jun;40(4):298- 308.
4. Anand IS. Anemia and chronic heart failure implications and treatment options. J Am Coll Cardiol. 2008 Aug 12;52(7):501-11.
5. Anand I, et al. Anemia and its relationship to clinical outcome in heart failure. Circulation. 2004 Jul 13;110(2):149-54.
6. Szachniewicz J, et al. Anaemia is an independent predictor of poor outcome in patients with chronic heart failure. Int J Cardiol. 2003 Aug;90(2-3):303-8.
7. Cavusoglu Y, et al. Iron deficiency and anemia in heart failure. Turk Kardiyol Dern Ars. 2017 Mar;45(Suppl 2):1-38.
8. Heidenreich PA, et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail. 2013 May;6(3):606-19.
9. Kocyigit I, et al. Early arterial stiffness and inflammatory bio-markers in normotensive polycystic kidney disease patients. Am J Nephrol. 2012;36(1):11-8.
10. Ponikowski P, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2016 Aug;18(8):891-975.
11. Bui AL, Horwich TB, Fonarow GC. Epidemiology and risk profile of heart failure. Nat Rev Cardiol. 2011 Jan;8(1):30-41.
12. Orscelik O, et al. Relationship between intrarenal renin-angiotensin activity and re-hospitalization in patients with heart failure with reduced ejection fraction. Anatol J Cardiol. 2018 Mar;19(3):205-12.
13. Groenveld HF, et al. Anemia and mortality in heart failure patients a systematic review and meta-analysis. J Am Coll Cardiol. 2008 Sep 2;52(10):818-27.
14. Tang WH, Yeo PS. Epidemiology of anemia in heart failure. Heart Fail Clin. 2010 Jul;6(3):271-8.
15. Tanner H, et al. The prevalence of anemia in chronic heart failure. Int J Cardiol. 2002 Nov;86(1):115-21.
16. Silverberg DS, et al. The use of subcutaneous erythropoietin and intravenous iron for the treatment of the anemia of severe, resistant congestive heart failure improves cardiac and renal function and functional cardiac class, and markedly reduces hospitalizations. J Am Coll Cardiol. 2000 Jun;35(7):1737-44.
17. Tang WH, Tong W, Jain A, Francis GS, Harris CM, Young JB. Evaluation and long-term prognosis of new-onset, transient, and persistent anemia in ambulatory patients with chronic heart failure. J Am Coll Cardiol. 2008 Feb 5;51(5):569-76. doi: 10.1016/j.jacc.2007.07.094.
18. Berk İG, Deniz A. Kalp Yetmezliği ve Anemiye Güncel Yaklaşım. Türk İç Hastalıkları Dergisi. 2014;21:63-7.
19. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005 Mar 10;352(10):1011-23.