Wide range lesions may occur in the vulvar region. The aim of the present study is to have an insight into the diverse morphologic spectrum of vulvar lesions. Total of 263 patients with primary vulvar complaints seen in Ankara Numune Training and Research Hospital Gynecology and Obstetrics Outpatient Clinic were recruited into study. The present retrospective study was carried out by compiling the data from archival records from January 2010 to May 2014. The vulvar biopsies specimens were studied for histomorphological features. The lesions were categorized as non-neoplastic, neoplastic and inconclusive; neoplastic ones were further divided into benign, malignant and premalignant.The age of the women ranged from 11 to 85 years (mean 46.27±14.32) with the maximum number of patients between 41 to 50 years of age. Most common clinical presentation was itching (126 cases; 47.9%). The commonest site of vulvar lesions was labia majora (145 cases, 55.1%). Non neoplastic lesions were more common (n = 172; 65.4%) than the neoplastic lesions (n =91; 34.6%). There were 81 (30.8%) benign lesions while 10 cases (3,8%) were malignant or premalignant ones. Amongst the non-neoplastic lesions, the most common histopathologic diagnosis was of lichen sclerosus et atrophicus (46 cases; 17,5%). Early recognition of vulvar lesions and a prompt biopsy diagnosis for all lesions with suspicious changes is of great significance.
___
1. Mohan H, Kundu R, Arora K, Punia RS, Huria A. Spectrum of vulvar lesions: a clinicopathologic study of 170 cases. Int J Reprod Contracept Obstet Gynecol. 2014; 3(1):175-80.
2. Foster DC. Vulvar disease. Obstet Gynecol. 2002;100(1):145-63.
3. Doyen J, Demoulin S, Delbecque K, Goffin F, Kridelka F, Delvenne P. Vulvar skin disorders throughout lifetime: about some representative dermatoses. Biomed Res Int. 2014;2014:595286.
4. Eva LJ. Screening and follow up of vulvar skin disorders. Best Pract Res Clin Obstet Gynaecol. 2012;26(2):175-88.
5. Lynch PJ, Moyal-Barracco M, Bogliatto F, Micheletti L, Scurry J. 2006 ISSVD classification of vulvar dermatoses: pathologic subsets and their clinical correlates. J Reprod Med. 2007;52(1):3-9.
6. Lynch PJ, Moyal-Barracco M, Scurry J, Stockdale C.J Low. 2011 ISSVD Terminology and classification of vulvar dermatological disorders: an approach to clinical diagnosis. Genit Tract Dis. 2012;16(4):339-44.
7. Bohl TG. Overview of vulvar pruritus through the life cycle. Clin Obstet Gynecol 2005;48(4):786-807
8. Fatoohi BY. Collins test in patients with vulvar pruritus. Int J Gynaecol Obstet. 2009;104(1):76.
9. O'Keefe RJ, Scurry JP, Dennerstein G, Sfameni S, Brenan J. Audit of 114 nonneoplastic vulvar biopsies. Br J Obstet Gynecol 1995;102(10):780-6.
10. Bowen AR, Vester A, Marsden L, Florell SR, Sharp H, Summers P. The role of vulvar skin biopsy in the evaluation of chronic vulvar pain. Am J Obstet Gynecol 2008;199(5):467.
11. Murphy R. Lichen sclerosus. Dermatol Clin. 2010;28(4):707-15.
12. Burrows LJ, Shaw HA, Goldstein AT. The vulvar dermatoses. J Sex Med. 2008;5(2):276-83.
13. Goldstein AT, Creasey A, Pfau R, Phillips D, Burrows LJ. A double-blind, randomized controlled trial of clobetasol versus pimecrolimus in patients with vulvar lichen sclerosus. J Am Acad Dermatol. 2011;4(6):e99-104.
14. Bhate K, Landeck L, Gonzalez E, Neumann K, Schalock P. Genital contact dermatitis: a retrospective analysis. Dermatitis. 2010;21(6):317-20.
15. Grazzini M, Gori A, Rossari S, Lotti T, Scarfì F, Massi D, de Giorgi V. Seborrheic keratosis of the vulva clinically mimicking a genital wart: a case study. Int J Dermatol. 2013;52(9):1156-7.
16. Léonard B, Kridelka F, Delbecque K, Goffin F, Demoulin S, Doyen J, Delvenne P. A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma. Biomed Res Int. 2014;2014:480573.
17. Madueke-Laveaux O S, Gogoi R, Stoner G. Giant fibroepithelial stromal polyp of the vulva: largest case reported. Annals of surgical innovation and research 2013;7(1):8.
18. Mehta V, Durga L, Balachandran C, Rao L. Verrucous growth on the vulva. Indian J Sex Transm Dis. 2009;30(2):125-26
19. Duhan N, Kalra R, Singh S, Rajotia N. Hidradenoma papilliferum of the vulva: case report and review of literature. Arch Gynecol Obstet. 2011;284(4):1015-7.
20. Ozdemir O, Sari ME, Yakut K, Erkilinc G, Unal DT, Atalay C. Leiomyoma in the vulva of a postmenapousal woman: Case report. Turkiye Klinikleri J Gynecol Obst. 2014;24(1):67-70.
21. Del Pino M, Rodriguez-Carunchio L, Ordi J. Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. Histopathology 2013;62(1):161-75.
22. Robinson Z, Edey K, Murdoch J. Invasive vulvar cancer. Obstet Gynaecol Reprod Med. 2011;21(5):129-36.