[Diş Hekimliğinde Artık Monomerler: Bir Literatür Derlemesi]

Artık monomerler diş hekimliğinde kullanılan birçok rezin içerikli restoratif materyalin yapısında bulunmaktadır. Reaksiyona girmeden kalan artık monomerler ağız sıvılarında çözünmekte ve ağız, diş ve çevre dokular için potansiyel risk oluşturmaktadır. Özellikle rezin materyallerin yapısında bulunan ve yetersiz polimerizasyondan dolayı polimer zincire katılamayan monomerlerin türlerinin ve miktarlarının belirlenmesi biyouyumluluk ve toksik etkilerin değerlendirilebilmesi için gereklidir. Bu makalede diş hekimliğinde kullanılan restoratif materyallerden salınabilen artık monomer ile ilgili genel bilgiler verilmiş ve artık monomer tipleri, biyolojik etkileri, salım nedenleri, salımı etkileyen faktörler ve salım miktarının belirlenmesinde kullanılan test yöntemleri sunulmuştur.

Residual Monomer in Dentistry: A Literature Review

Residual monomers are including in the structure of many restorative materials using in dentistry. Remaining unreacted these monomers have dissolved in oral fluids and potential risks for mouth, teeth and surrounding tissues. Especially it is necessary to assessment of biocompatibility and toxic effect, the types and amounts presenting in the composition of resin materials and due to insufficient polymerization. In this article provided general information about residual monomers which can be released from restorative materials used in dentistry and types of residual monomers, biological effects, and causes release, factors affecting releasing and presented the test methods used to determine the amount of release.

___

  • 1. Van Landuyt KL, Snauwaert J, De Munck J, Peumans M, Yoshida Y, Poitevin A., Systematic review of the chemical composition of contemporary dental adhesives. Biomater. 2007;28(26):3757-85.
  • 2. Çökeliler D. Polimer Kimyası. Başkent Üniversitesi Yayınları, Ankara, 2010:8-9.
  • 3. Saçak M. Polimer Kimyası. Gazi Kitabevi, Ankara, 2002:14-21.
  • 4. Altunsoy M. Farklı sürelerde polimerize edilen adeziv sistemlerin yapılarından salınan artık monomer miktarının araştırılması. Doktora Tezi, Selçuk Üniversitesi, Konya, 2012.
  • 5. Paul SJ, Leach M, Rueggeberg FA, Pashley DH. Effect of water content on the physical properties of model dentine primer and bonding resins. J Dent. 1999;27(3):209-14.
  • 6. O'Brein WJ. Dental Materials and Their Selection. Quintessence Publishing Co, Illinois. 3rd edition. 2002;75-91.
  • 7. Botsalı MS. Rezin esaslı fissur örtücülerin farklı ısık kaynakları ile polimerizasyonu sonrasında açığa çıkan artık monomer miktarının, yüzey sertliginin ve baglanma dayanımının arastırılması. Doktora Tezi, Selçuk Üniversitesi, Konya, 2008.
  • 8. Dayangaç GB. Kompozit rezin restorasyonlar. Güneş Kitabevi, Ankara, 2000:15-9.
  • 9. Özel E, Soyman M. LED ışık kaynakları. Atatürk Üniv. Diş Hek. Fak. Derg, 2003;13(3):13-7.
  • 10. Altun C. Kompozit dolgu materyallerinde son gelişmeler. Gülhane Tıp Dergisi, 2005.47(1):77-82.
  • 11. Tuna EB. Süt ve sürekli dişlerde kullanılan dört farklı kompozit materyalden monomer salınımının karşılaştırmalı olarak incelenmesi. Doktora Tezi, İstanbul Üniversitesi, İstanbul, 2006.
  • 12. Peutzfeldt A. Resin composites in dentistry: the monomer systems. Eur J Oral Sci. 1997;105(2):97-116.
  • 13. Komurcuoglu E, Olmez S, Vural N. Evaluation of residual monomer elimination methods in three different fissure sealants in vitro. J Oral Rehabil. 2005;32(2):116-21.
  • 14. Cadenaro M, Antoniolli F, Sauro S, Tay FR, Di Lenarda R, Prati C, Biasotto M, Contardo L, Breschi L. Degree of conversion and permeability of dental adhesives. Eur J Oral Sci 2005;113(6):525-30.
  • 15. Cardoso Pde C, Loguercio AD, Vieira LC, Baratieri LN, Reis A. Effect of prolonged application times on resin-dentin bond strengths. J Adhes Dent. 2005;7(2):143-9
  • 16. Üşümez S, Büyükyılmaz T, Karaman Aİ, Gündüz B. Degree of conversion of two lingual retainer adhesives cured with different light sources. Eur J Orthod. 2005;27(2):173-9.
  • 17. Stansbury JW, Dickens SH. Determination of double bond conversion in dental resins by near infrared spectroscopy. Dent Mater. 2001;17(1):71-9.
  • 18. Holmes RG, Rueggeberg FA, Callan RS, Caughman F, Chan DC, Pashley DH, Looney SW. Effect of solvent type and content on monomer conversion of a model resin system as a thin film. Dent Mater. 2007;23(12):1506-12.
  • 19. Geurtsen W. Biocompatibility of resin-modified filling materials. Crit Rev Oral Biol Med. 2000;11(3):333-55.
  • 20. Goossens A. Contact allergic reactions on the eyes and eyelids. Bull Soc Belge Ophtalmol. 2004;2(292):11-7.
  • 21. Paranjpe A, Bordador LC, Wang MY, Hume WR, Jewett A. Resin monomer 2- hydroxyethyl methacrylate (HEMA) is a potent inducer of apoptotic cell death in human and mouse cells. J Dent Res. 2005;84(2):172-7.
  • 22. Söderholm KJ, Mariotti A. Bis-GMA-based resins in dentistry: Are they safe? JADA. 1999;130(2):201-6.
  • 23. Rueggeberg FA, Margeson DH. The effect of oxygen inhibition on an unfilled/filled composite system. J Dent Res. 1990;69(10):1652-8.
  • 24. Nunes TG, Ceballos L, Osorio R, Toledano M. Spatially resolved photopolymerization kinetics and oxygen inhibition in dental adhesives. Biomaterials. 2005;26(14):1809-17.
  • 25. Sideridou ID, Achilias DS. Elution study of unreacted Bis-GMA, TEGDMA, UDMA, and Bis-EMA from light-cured dental resins and resin composites using HPLC. J Biomed Mater Res B Appl Biomater. 2005;74(1):617-26.
  • 26. Altıntaş S, Üşümez A. Evaluation of monomer leaching from a dual cured resin cement. J Biomed Mater Res Part B:Appl Biomater. 2008;86(2):523-9.
  • 27. Tabatabaee MH, Mahdavi H, Zandi S, Kharrazi MJ. HPLC analysis of eluted monomers from two composite resins cured with LED and halogen curing lights. J Biomed Mater Res B Appl Biomater. 2009;88(1):191-6.
  • 28. Eliades T, Eliades G, Brantley WA, Johnston WM. Polymerization efficiency of chemically cured and visible light-cured orthodontic adhesives: degree of cure. Am J Orthod Dentofacial Orthoped. 1995;108(3):294-301.
  • 29. Al-Hiyasat AS, Darmani H, Milhem MM. Cytotoxicity evaluation of dental resin composites and their flowable derivatives. Clin Oral Investig. 2005;9(1):21-5.
  • 30. Mohsen NM, Craig RG, Hanks CT. Cytotoxicity of urethane dimethacrylate composites before and after aging and leaching. J Biomed Mater Res. 1997;39(2):252-60.
  • 31. Kehe K, Reichl FX, Durner J, Walther U, Hickel R, Forth W. Cytotoxicity of dental composite components and mercury compounds in pulmonary cells. Biomaterials. 2001;22(4):317-22.
  • 32. Schmalz G. The biocompatibility of non-amalgam dental filling materials. Eur J Oral Sci. 1998;106(2 Pt 2):696-706..
  • 33. Atkinson JC, Diamond F, Eichmiller F, Selwitz R, Jones G. Stability of bisphenol A, triethylene-glycol dimethacrylate, and bisphenol A dimethacrylate in whole saliva. Dent Mater. 2002;18(2):128-35.
  • 34. Tarumi H, Imazato S, Narimatsu M, Matsuo M, Ebisu S. Estrogenicity of fissure sealants and adhesive resins determined by reporter gene assay. J Dent Res. 2000;79(11):1838-43.
  • 35. Wada H, Tarumi H, Imazato S, Narimatsu M, Ebisu S. In vitro estrogenicity of resin composites. J Dent Res. 2004;83(3):222-6.
  • 36. Schafer TE, Lapp CA, Hanes CM, Lewis JB, Wataha JC, Schuster GS. Estrogenicity of bisphenol A and bisphenol A dimethacrylate in vitro. J Biomed Mater Res. 1999;45(3):192-7.
  • 37. Arenholt-Bindslev D, Breinholt V, Preiss A, Schmalz G. Time-related bisphenol-A content and estrogenic activity in saliva samples collected in relation to placement of fissure sealants. Clin Oral Invest. 1999;3(3):120-5.
  • 38. Geurtsen W, Lehmann F, Spahl W, Leyhausen G. Cytotoxicity of 35 dental resin composite monomers/additives in permanent 3T3 and three human primary fibroblast cultures. J Biomed Mater Res. 1998;41(3):474-80.
  • 39. Olea N, Pulgar R, Pérez P, Olea-Serrano F, Rivas A, Novillo-Fertrell A, Pedraza V, Soto AM, Sonnenschein C. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect, 1996;104(3):298-305.
  • 40. Büyüközer ŞT. Farklı ışık kaynakları ile polimerize edilen çeşitli adeziv sistemlerden farklı dentin kalınlıkları altında salınan artık monomerlerin yüksek basınçlı likit kromatografisiyle incelenmesi. Doktora Tezi, Selçuk Üniversitesi, Konya, 2009.
  • 41. Munksgaard EC, Peutzfeldt A, Asmussen E. Elution of TEGDMA and BisGMA from a resin and a resin composite cured with halogen or plasma light. Eur J Oral Sci. 2000;108(4):341-5.
  • 42. Geurtsen W. Substances released from dental resin composites and glass ionomer cements. Eur J Oral Sci. 1998;106(2 pt 2):687-95.
  • 43. Ortengren U, Wellendorf H, Karlsson S, Ruyter IE. Water sorption and solubility of dental composites and identification of monomers released in an aqueous environment. J Oral Rehabil. 2001;28(12):1106-15.
  • 44. Moharamzadeh K, Van Noort R, Brook IM, Scutt AM. HPLC analysis of components released from dental composites with different resin compositions using different extraction media. J Mater Sci Mater Med. 2007;18(1):133-7