ÖZLEM YILMAZ, LÜTFİYE KANIT, Berrin E. OKUR, Şakire PÖĞÜN

8971

Effects of pre-and post-treatment of nicotine on active avoidance learning

Three-months-old Sprague Dawley rats received nicotine (0.6 mg/kg) or saline s.c. either before or after active avoidance learning trials. Behavioral testing was continued without nicotine treatment once a week for 4 weeks. Effects of nicotine on motor performance was tested using the inclined plane. Female rats that received nicotine before learning trials performed worse than control females whereas males that received nicotine performed better than control males. Nicotine applied after learning trials had no effect on learning performance (retention) in either sex. Our results show that nicotine is effective during the acquisition phase of active avoidance learning and the observed effects are sexually dimorphic: Nicotine improves performance in males but worsens it in females.
Medical Journal of Ege University-Cover
  • ISSN: 1017-7698
  • Yayın Aralığı: 3
  • Başlangıç: 2018
  • Yayıncı: Ege Üniv. Tıp Fak.
Arşiv
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