YUMUŞAK DAMAKTA VERRUKA VULGARİS: İmmunohistokimyasal Değerlendirmesi Olan Bir Olgu Sunumu

Verruca vulgaris (VV) oral kavitede tanımlanmıştır. Ancak yumuşak damak mukozasında VV oldukça nadirdir.Bu lezyonlar ciltte bulunan VV ile benzer histolojik ve klinik bulgular gösterdiği taktirde oral verruca tanısıalmalıdır. Human papillomavirus (HPV) antijen oral VV vakalarının % 55-75'inde tespit edilmiştir. HPV 2, 4 ve 57oral VV' den izole edilmiştir. Cilt ile ilişkili HPV tiplerinin oral lezyonları azalan sıklıkla, baskın olarak dudak,damak, bukkal mukoza, dil ve gingivada lokalizedir. Buna karşılık mukozal HPV tipleri damak, dudak, dil, bukkalmukoza ve gingivada yerleşim gösterir. 62 yaşındaki bayan hastanın yumuşak damakğındaki papillomatözlezyonundan biopsi spesmeni alındı. Kesitlerde üst katlarındaki hücrelerde hiperkeratoz, parakeratoz vekoilositotik değişiklikler gösteren epitelin papiller büyümesi ile oluşan lezyon izlendi. Kesitler gen spesifikpapillomavirus antijenini gösteren immunoperoxidase-PAP method (Dako-PAP, USA) ile boyandı ve yüzeyelparakeratinize ve granüler hücrelerde grup spesifik antijen varlığı görüldü. Bu histolojik özellikler ve klinikbulgular ciltte görülen VV ile oldukça uyumlu idi

Anahtar Kelimeler:

Verruka, vulgaris, yumuşak damak

Verruca Vulgaris on The Soft Palate: A Case Report with Immunohistochemical Evaluation

Verrucae vulgares (VV) have been described in the oral cavity. ButVVon the soft palatal mucosa are very rare. It has been suggested that the diagnosis of oral verruca should be confined to those lesions which show clinical and histological criteria similar to those found in VV of the skin. Human papillomavirus (HPV) antigen has been detected in 55-75%of oralVVcases.HPV2,-4 and -57 were isolated from oralVV. The oral lesions of skin-related HPV types are localized predominantly to the lip, palate, buccal mucosa, tongue and gingiva with decreasing frequency; in contrast those of mucosal HPV types are located in the palate, lip, tongue, buccal mucosa and gingiva.Abiopsy specimen of an papillomatous lesion on the soft palate was taken from a 62-year-oldwoman.The sections showed papillary growth of the epitheliumwith hyperkeratosis, parakeratosis and koilocytotic changes of the cells located in the upper layers of the oral squamous cell epithelium. Sections were stained with the immunoperoxidase-PAP method (Dako-PAP, USA) to demonstrate the genus-specific papillomavirus antigen. Our case demonstrated the presence of the group-specific antigen in the superficial parakeratinized and granular cells.These histological ve clinical features correspondedwell to those ofVVon the skin.

Keywords:

Verruca, vulgaris, soft palate,

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