TİROİDİN ONKOSİTİK DEĞİŞİKLİK GÖSTEREN TÜMÖRLERİNE DÖRT OLGU EŞLİĞİNDE GENEL BAKIŞ

Tiroid follikül epitel hücrelerindeki onkositik değişiklikler benign uçta Hashimoto tiroiditi, malign uçta Hurthle hücreli karsinom yada medüller karsinom gibi geniş bir spektrumda izlenebilirler. Biz onkositik değişiklik gösteren dört tiroid tümörünü histopatolojik özellikleriyle tartıştık. Olguların üçü kadın biri erkektir. Tümörlerin boyutları 1-6 cm arasındadır. Histolojik olarak tüm tümörlerde follikül epitel hücrelerinde onkositik değişiklikler izlenmiştir. İki olguda papiller yapılanma izlenirken diğer ikisinde folliküler büyüme paterni izlenmiştir. Bir olguda tiroid papiller karsinomda tipik olarak izlenen nükleuslarda saydamlaşma dikkati çekmiştir. Diğer vakalarda nükleuslar vesiküle olup belirgin nükleol içermektedir.İki olguda tümör çevresindeki tiroid dokusunda Hashimoto tiroiditi bulguları izlenmiştir. Histopatolojik olarak birbirine benzeyen ve zaman zaman tanı zorluğu yaratan biyolojik davranış ve prognoz farklılığı göst mörü sunulmuştur.

Anahtar Kelimeler:

Hurthle hücresi, papiller karsinom, adenom, tiroid

General Features of Four CasesWith Oncocytic Change in Thyroid Tumors

Oncocytic change in thyroid follicular cells can take place in a range of pathological conditions with Hashimoto's thyroiditis on the benign and Hurthle cell carcinoma or medullary carcinoma on the malignant ends of the spectrum.We evaluated four cases of thyroid tumors composed of oncocytic cells. Three patients were women and one was a man. The tumors measured between 1 to 6 cm. Histologically all tumors showed oncocytic change in thyroid follicular cells.Two cases showed papillary features, and in the others the follicular growth pattern was predominant. In one case, the classical optically clear nuclei of papillary carcinoma were present. The rest had vesicular nuclei and prominent nucleoli. In two cases the peritumoral area showed the features of Hashimoto's thyroiditis. We report 4 cases with oncocytic thyroid neoplasms that might have different biological and prognostic features.

Keywords:

Hurthle cell, papillary carcinoma, adenoma, thyroid,

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