Celalettin CAMCI, Zahit BOLAMAN, Hulki M. SÖNMEZ, Ayşin ÖGE, Ceyhan ÇİÇEK, İrfan YAVAŞOĞLU

GEBELİĞE BAĞLI COOMBS NEGATİF HEMOLİTİK ANEMİ

Anahtar Kelimeler:

Gebelik, otoimmün hemolitik anemi, direk antiglobulin test

Pregnancy Induced Coombs’ Negative Hemolytic Anemia

Hemolytic anemia associated with pregnancy is a rare and usually Coombs’ test (direct antiglobulin test=DAT) is negative. In this paper we presented a woman who had DAT negative hemolytic anemia during the second pregnancy. In patient hemolysis was controlled with steroid therapy.

Keywords:

Pregnancy, autoimmune hemolytic anemia, direct antiglobulin test,

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1. Benraad CE, Scheerder HA, Overbeeke MA. Autoimmune haemolytic anemia during pregnancy. Eur J Obstet Gynecol Reprod Biol 1994; 55: 209-11.
2. Sokol RJ, Hewith S, Stamps B. Erythrocyte autoantibodies, autoimmune hemolysis and pregnancy. Vox Sang 1982; 43: 169-76.
3. Chaplin HR, Cohen R, Bloomberg G, Kaplin JH, Moore JA, Dorner I. Pregnancy and idiopathic autoimmune haemolytic anemia; a prospective study during 6 months gestation and 3 months gestation and 3 months postpartum. Br J Haematol 1973; 24: 219-29.
4. Baurmann R, Rubin H. Autoimmune hemolytic anemia during pregnancy with hemolytic disease in the newborn. Blood 1973; 41: 293-7.
5. Hershko C, Berrebi A, Restnitzky P, Erdor A. Relapsing hemolytic anemia of pregnancy with negative antiglobulin reaction. Scand J Haematol 1976; 16: 135-40.
6. Yam P, Wilkinson L, Petz LD, Garraty G. Studies on hemolytic anemia in pregnancy with evidence of autoimmunization in a patient with a negative direct antiglobulin (Coombs) test. Am J Hematol 1980; 8: 23-9.
7. Gillard BD, Baxter E, Evans RS. Red-cell antibodies in acquired hemolytic anemia with negative antiglobulin serum tests. N Eng J Med 1971; 285: 252-6.
8. Starksen NF, Bell WR, Kickler TS. Unexplained hemolytic anemia associated with pregnancy. Am J Obstet Gynecol 1983; 146: 617-22.
9. Goodal HB, Ho-Yen DO, Clark DM, Thompson MAR, Browning MCK, Crowder AM. Haemolytic anemia of pregnancy. Scan J Haematol 1979; 22: 185-91.