Veysel HAKSÖYLER, Ertuğrul BAYRAM, Mehmet Ali ÇAPARLAR, Tolga KÖSECİ, Plat OLGUN

Kemoterapinin Neden Olduğu Saç Dökülmesinin Engellenmesinde Saçlı Deri Soğutma Yönteminin Etkinliği ve Güvenilirliği

GİRİŞ ve AMAÇ: Saç dökülmesi, sitotoksik kemoterapilerin en korkulan yan etkilerinden biri olup çok sayıda hastanın psikososyal durumunu olumsuz yönde etkilemektedir. Çalışmamızda kemoterapi sırasında saçlı deri soğutma yönteminin kemoterapşye bağlı saç dökülmesini önlemedeki etkinliğini, kısa ve uzun dönemdeki istenmeyen etkilerini ve hastanın psikososyal durumunda yarattığı değişiklikleri incelemeyi amaçladık YÖNTEM ve GEREÇLER: Eylül 2018 ve Ocak 2020 tarihleri arasında saçlı deri soğutma yöntemini kullanan 76 ve kullanmayan 75 olmak üzere toplam 151 hasta çalışmaya dahil edildi. Saç dökülme derecesini belirlemek için National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) treatment related alopecia grading system kullanıldı BULGULAR: Saçlı deri soğutma sistemini kullanan hastalarda grade 1 saç dökülmesi oranı %77,6 iken kullanmayan hastalarda bu oran %1,3 idi. Yöntemi kullanan ve kullanmayan hastalar arasında izlem süresi boyunca yan etki profili acısından anlamlı bir fark bulunmadı. TARTIŞMA ve SONUÇ: Saçlı deri soğutma sisteminin kemoterapi ilişkili saç dökülmesini engelleme konusundaki bilgiler gün geçtikçe artıyor olmasına rağmen konu ile ilgili randomize,kontrollü,prospektif çalışma sayısı çok azdır. Bu nedenle çalışmamızın bu yöntemin erkili ve güvenilir olduğuna dair sunduğu verilerin literatür için değerli olduğunu düşünüyoruz.

Effectiveness and Reliability of Scalp Cooling in Preventing Hair Loss Caused by Chemotherapy

INTRODUCTION: Hair loss is one of the most feared side effects of cytotoxic chemotherapy and affects the psychosocial status of the patient the most. In our study, we aimed to examine to what extent cooling the scalp with a scalp cooling system can prevent hair loss during chemotherapy, the short- and long-term toxicity of this system, and its effect on the psychosocial status of the patien METHODS: A total of 151 patients were enrolled; of them, 76 and 75 were sequentially using scalp cooling and the control group. We used National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) treatment related alopecia grading system for grading hair loss RESULTS: The proportion of grade 1 (less than 50% off hair loss) alopecia was 77,6% in the scalp cooling group and %1,3 in the control group. In the patients who used the system, no short- and long-term side effects that could be considered significant compared to the control group were not detected. DISCUSSION AND CONCLUSION: Although data on the effectiveness and reliability of scalp cooling used to prevent alopecia caused by chemotherapy is increasing day by day, the number of randomized, controlled, prospective studies on this subject is too few. Our study reveals that scalp cooling reliably and significantly reduces chemotherapy-induced hair loss is well tolerated and improves patients mental health and social condition significantly. However, there is still a need for studies with larger groups.

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