İbrahim FIRAT, Erol R. BOZKURT, Damla HAKTANIR, KÜRŞAT ÖZER

Parosteal osteoclastic osteosarcoma in the left tarsal joint of a cat

Onbir yaşlı, Siyam melezi erkek kedinin sol tarsal eklemi lateral yüzünde parosteal (jukstakortikal) ostesarkom olgusu tespit edildi. Radyografide tümör ile alttaki kortikal kemik dokusunun radyolusent bir demarkasyon hattı ile ayrıldığı dikkati çekti. Tümoral kitlenin hareketsiz, yumuşaktan serte farklılaşan kıvamda olduğu ve kesit yüzünde kistik alanlar içerdiği izlendi. Mikroskobik olarak, tümöral dokunun çoğunlukla veziküler çekirdeğe sahip, iri, oval ya da iğsi şekilli hücrelerden; kısmen de epiteloid benzeri mezenşimal elemanlar ile çok sayıdaki osteoklastik dev hücreden oluştuğu gözlendi. Hücresel pleomorfizm ve mitotik figür tespit edildi. Tümöral hücrelerin, kısmen hiyalinize kollojen benzeri osteoid matriks ile nadiren osteokondroid alanlar meydana getirdiği izlendi. Belirgin nekrozunda olduğu tümoral kitle içinde yer yer anevrizmal kist benzeri damarsal yapılar ve bunlarla ilişkili osteoklastları andıran çok sayıda dev hücre gözlendi. Çok sayıda osteoklastik hücre ve anevrizmal kistik değişiklikler içeren tümör radyolojik ve histomorfolojik bulgulara göre parosteal osteoklastik osteosarkom olarak adlandırıldı.

Anahtar Kelimeler:

kedi, eklem hastalıkları, sarkom, tümörler

Bir kedinin sol tarsal ekleminde parosteal osteoklastik osteosarkoma olgusu

A parosteal (juxtacortical) osteosarcoma case was diagnosed on the lateral aspect of the left tarsal joint of an 11-year-old male Siamese-crossbred cat. A radiolucent line of demarcation between the tumor and the underlying cortical bone was present. The immobile mass was of soft to firm consistency with cystic areas on the cut surface. Histologically, the tumor tissue consisted generally of large, ovoid or fusiform cells with vesicular nuclei and partially of epithelioid like mesenchymal elements and abundant osteoclastic giant cells. Cellular pleomorphism and mitotic activity were found. The tumor cells were observed to have produced partially hyalinized collagen like osteoid matrix and constituted few crude osteochondroid areas. Partial aneurismal cysts like vascular structures in association with numerous giant cells resembling osteoclasts were present in the tumoral mass with marked necrosis. Based on the radiological and histomorphological features, the tumor with numerous osteoclasts and aneurysmal cystic changes was classified as parosteal osteoclastic osteosarcoma.

Keywords:

cats, joint diseases, sarcoma, tumours,

PDF

___

1. Engle GC, Brodey RS: A retrospective study of 395 feline neoplasms. J Amer Hosp Assoc, 5, 21-31, 1969.
2. Thompson KG, Pool RR: Tumors of bones. In, Meuten DJ (Ed): Tumours in Domestic Animals. 4th ed., pp. 245-317, 2121 State Avenue, Ames, IA 50014, USA: Iowa State Press, A Blackwell Publishing Company, 2002.
3. Slayter MV, Boosinger TR, Pool RR, Dämmrich K, Misdorp W, Larsen S: Histological Classification of Bone and Joint Tumors of Domestic Animals. World Health Organization. 2nd series, Vol. 1. Armed Forces Institute of Pathology, American Registry of Pathology, Washington D.C., 1994.
4. Banks WC: Parosteal osteosarcoma in a dog and a cat. J Amer Vet Med Assoc, 158, 1412-1415, 1971.
5. Turrel JM, Pool RR: Primary bone tumors in the cat: A retrospective study of 15 cats and a literature review. Vet Radiol, 23, 152-166, 1982.
6. Liu SK, Dorfman HD, Patnaik AK: Primary and secondary bone tumours in the cat. J Small Anim Pract, 15, 141-156, 1974.
7. Jacobson SA: The Comparative Pathology of the Tumors of Bone. Charles C. Thomas, Springfield, IL., 1971.
8. Griffith JW, Dubielzig RR, Riser WH, Jezyk P: Parosteal osteosarcoma with pulmonary metastases in a cat. Vet Pathol, 21, 123-125, 1984.
9. Moores AP, Beck AL, Baker JF: High-grade surface osteosarcoma in a dog. J Small Anim Pract, 44, 218-220, 2003.