Elham HASSAN, Faisal TORAD, Ashraf ABU-SEIDA, Azza HASSAN

Mandibular Hypertrophic Osteodystrophy Fibrosa in a German Shepherd Puppy

Hypertrophic osteodystrophy is a developmental disease of unknown etiology and affcts primarily young rapidly growing large and giant breed dogs. The present study reports a case of mandibular hypertrophic osteodystrophy fibrosa in a 6-month-old male German shepherd puppy admitted with a history of one month decreased appetite, difficulty in chewing, and open mouth with continuous drooling. Clinical examination revealed thickened mandible and filling of the intermandibular space with hard tissue. Radiography revealed bone-like material filling the intermandibular space. Biopsy from the thickened mandibular mass demonstrated marked osteoclastic activity and resorption of bone trabeculae that were replaced by fibrous connective tissue. The marrow cavity was filled with massive fibrous tissue mixed with hemorrhage and osteoclasts. Hypertrophic osteodystrophy fibrosa should be taken into consideration in dogs with mandibular masses. Radiography and histologic evaluation are suitable tools to diffrentiate hypertrophic osteodystrophy. fibrosa from mandibular neoplasms and cranio-mandibular osteopathy.

Bir Alman Çoban Köpeği Yavrusunda Mandibular Hipertrofik Fibröz Osteodistrofi Olgusu

Hipertrofik osteodistrofi, etiyolojisi bilinmeyen bir gelişim dönemi hastalığıdır ve birincil olarak genç ve hızlı büyüyen büyük ırk köpekleri etkiler. Bu çalışma ile, bir aydır süren iştahta azalma, çiğnemede zorlanma, ağzın sürekli açık kalması ve salya birikimi semptomları olan 6 aylık bir erkek Alman çoban köpeğinde mandibular fibröz hipertrofik osteodistrofi vakası bildirildi. Klinik muayenede mandibulanın kalınlaştığı ve intermandibular boşluğun sert doku ile dolu olduğu belirlendi. Radyografide intermandibular boşluğun kemik benzeri materyal ile dolduğu görüldü. Kalınlaşmış mandibular kitleden alınan biyopside belirgin osteoklastik aktivite ile birlikte kemik trabeküllerinin rezorpsiyonu ve fibröz bağ dokusu ile yer değiştirdiği gözlendi. Kemik boşluğu, kanama ve osteoklastlarla karışık halde masif fibröz doku ile doluydu. Mandibular kitle belirlenen köpeklerde fibröz hipertrofik osteodistrofi dikkate alınmalıdır. Radyografi ve histolojik değerlendirme, fibröz hipertrofik osteodistrofiyi mandibular neoplazilerden ve kranio-mandibular osteopatiden ayırmak için uygun yöntemlerdir.

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