Effect of Sugammadex and Rocuronium Combination on Cranial Neurotoxicity in Rats: Experimental Study

Sugammadex is frequently used in clinical anesthetic practice. In order to determine whether sugammadex has neurotoxic effect, histopathological evaluation and antioxidant status of brain and cerebellum tissues were investigated. Thirty-two adult sprague dawley rats were divided into four groups. Purine Control Group (Group 1, n=8) had no action. The control group (Group 2, n=8) received 16 mg/ kg serum physiologic, the sugammadex group (Group 3, n=8) received 16 mg/kg sugammadex and the sugammadex+rocuronium group (Group 4, n=8) received 16 mg/kg sugammadex and 1 mg/kg rocuronium. After drug administration, brain and cerebellum tissues were evaluated histological and biochemically for and oxidative damage. The overall structure of the brain and cerebellum tissues were normal in all groups. Images of the layers and the neurons contained there in were normal. No pathological findings were found. There had no statistically significant diffrence between the groups in terms of glutathione enzyme activity levels (GSH-Px) and the malondialdehyde (MDA) levels in rat brain. GSH-Px and MDA levels had a slight increase in sugammadex and sugammadex+rocuronium group in cerebellum tissues. These increases were statistically significant. But this increase did not cause any histopathological damage to the cerebellum tissue. The study demonstrates that sugammadex is safe for reversal of rocuronium effcts in rats. Sugammadex in the dose ranges used in the studies, did not produce adverse effcts in rats brain and cerebellum tissues.

Ratlarda Sugammadex ve Rocuronium Kombinasyonunun Kraniyal Nörotoksisite Üzerine Etkisi: Deneysel Çalışma

Sugammadeks klinik anestezi uygulamalarında sıklıkla kullanılır. Sugammadeksin nörotoksik etkiye sahip olup olmadığını belirlemek için, beyin ve serebellum dokularının histopatolojik değerlendirmesi ve antioksidan durumu araştırıldı. Otuz iki erişkin sprague dawley sıçanı dört gruba ayrıldı. Purin Kontrol Grubuna (Grup 1, n=8) işlem yapılmadı. Kontrol grubuna (Grup 2, n=8) 16 mg/kg serum fizyolojik verildi. Sugammadex grubuna (Grup 3, n=8) 16 mg/kg sugammadex ve sugammadex+rocuronium grubuna (Grup 4, n=8) 16 mg/kg sugammadeks ve 1 mg/kg rokuronyum verildi. İlaç uygulamalarından sonra beyin ve beyincik dokuları histolojik ve oksidadif hasar açısından biyokimyasal olarak değerlendirildi. Beyin ve beyincik dokusunun genel yapısı tüm gruplarda normaldi. Katmanların ve içerdiği nöronların görüntüleri normaldi. Patolojik bulgu bulunamadı. Gruplar arasında sıçan beyninde glutatyon enzim aktivite düzeyleri (GSH-Px) ve malondialdehit (MDA) düzeyleri açısından istatistiksel olarak anlamlı bir fark yoktu. Serebellum dokularında GSH-Px ve MDA düzeyleri sugammadeks ve sugammadeks+rocuronium grubunda hafif bir artış gösterdi. Bu artışlar istatistiksel olarak anlamlıydı. Ancak bu artış, beyincik dokusunda histopatolojik hasara neden olmadı. Çalışma, sugammadeksin sıçanlarda rocuronyum etkisinin tersine çevrilmesinde güvenli olduğunu göstermektedir. Çalışmada kullanılan doz aralıklarında sugammadeks sıçan beyni ve beyincik dokularında olumsuz etki oluşturmamıştır.

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