RECAİ TUNCA, Güneş SERİN, Erkmen Tuğrul EPİKMEN, AHMET AYDOĞAN, HAMDİ AVCI

İki köpekte granüloza hücre tümörü

Granüloza hücre tümörleri, granüloza hücrelerinden köken alan ve ovaryumun en yaygın görülen seks kord-gonadostromal tümörlerdendir. Bu vaka sunumu ile iki köpekte granüloza hücre tümörü klinik ve patolojik bulguları ile tanımlandı. Birinci olguda (iki yaşlı, kırma köpek) klinik olarak orta derecede vulvar ödem ve hemorajik vajinal akıntı ve transabdominal ultrasonografide sağ ovaryum üzerinde 8.0 mm ve 10.0 mm boyutlarında iki kistik yapı dikkati çekti. Önceden kısırlaştırıldığı ve son üç aydır aralıklı olarak seyreden kanamalı vajinal akıntının görüldüğü bildirilen ikinci olguda (dokuz yaşlı, Alman çoban köpeği), klinik muayenede şiddetli vulvar ödem ile transabdominal ultrason muayenesinde sağ paralumbal bölgede hiperekojenik doku ile çevrelenmiş kistik bir yapıya rastlandı. Birinci olguda, makroskobik incelemede her iki ovaryumun dış yüzünde çapları 1.0 mm’den 3.0 mm’ye varan büyüklüklerde, çok sayıda, boz-beyaz renkli ve sert kıvamlı nodüller mevcuttu. Sağ ovaryumun dış yüzünde biri 8.0 mm diğeri 10.0 mm çapında, içleri seröz sıvı dolu kistler bulunmaktaydı. İkinci olguda, sağ ovaryum yüzeyinde biri 1.0 mm diğeri 10.0 mm çapında, boz-beyaz renkte ve sert kıvamlı nodüller bulunmaktaydı. Mikroskobik incelemede; her iki olguda, fibröz stroma ile sınırlandırılmış kistik ya da solid yapılar halinde neoplastik alanlar dikkati çekti. Bu alanlar; sitoplazmaları vakuollü, çekirdekleri yuvarlak ya da oval şekilli, pleomorfik, bir ya da birkaç sıra halinde dizilmiş neoplastik granüloza hücrelerinden oluşmuştu. Bu yapıların bazılarının merkezlerinde eozinofilik globuler Call-Exner cisimciği dikkati çekti. Her iki olguda da post operatif- tedaviyi takiben vulvar ödem ve vajinal kanamada azalma, ilerleyen haftalarda da tam iyileşme sağlandı.

Anahtar Kelimeler:

klinik görünüm, köpek, tanecikli hücreler, tümörler, neoplazma, vajinal hastalıklar

Granulosa cell tumor in two dogs

Granulosa cell tumors, arised from granulosa cells, are the most common sex-cord gonadostromal tumor of the ovary. In the present report, granulosa cell tumor in two dogs was described with its clinical and pathologic findings. In the first case (2-years-old, mongrel bitch), moderate vulvar edema and hemorrhagic vaginal discharge was observed in clinical examination. In transabdominal ultrasonography, two cysts, 8.0 and 10.0 mm in diameters, were determined on the right ovary. In the second case (9-years-old, German shepherd spayed bitch), severe vulvar edema and hemorrhagic vaginal discharge for three months were reported. A cystic formation surrounded by a hyperechogenic tissue was detected in the right paralumbal area during transabdominal ultrasonography. Macroscopically, in the first case surfaces of the both ovary had, many grayish-white nodules with firm in concistency with sizes varying from 1.0 mm to 3.0 mm in diamaters. In addition, the surface of the right ovary had also two serous cysts with 8.0 mm and 10.0 mm in diamaters. Microscopically, in both cases, cystic or solid neoplastic areas surrounded by fibrous tissue were observed. The neoplastic areas were consisted of one or more rows of pleomorphic granulosa cells with oval or round nuclei and vacuolated cytoplasm. In some of the these neoplastic structures, centrally located globular eosinophlic Call-Exner body were noted. Following postoperative treatment, a decrease in vulvar edema and vaginal bleeding were observed, and full recovery was obtained in both cases in the next weeks.

Keywords:

clinical aspects, dogs, granulosa cells, tumours, neoplasms, vaginal diseases,

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