Kerem URAL, MEHMET GÜLTEKİN, Hasan ERDOĞAN

Efficacy of Topical Curcuma longa and Nigella sativa Combination for Feline Head and Neck Dermatitis: An Open Pilot Study

Two medicinal plants, Curcuma longa (turmeric) and Nigella sativa (black cumin), have generated growing interest for their therapeutic antiinflammatory action. We hypothesize that commercially available topical C. longa and N. sativa cream (Dermacumin cream®) will significantly decrease both the Feline Dermatitis Extent (FDE) and Severity Index (SI) and the pruritus scores after 3 weeks of twice-daily treatment of feline head and neck dermatitis. Ten client-owned cats with feline head and neck dermatitis which had received no previous treatment. FDE and SI scores gradually decreased on days 7 (P

Kedi Baş ve Boyun Dermatitisi İçin Topikal Curcuma longa ve Nigella sativa Kombinasyonunun Etkinliği: Açık Pilot Çalışma

İki şifalı bitki, Curcuma longa (zerdeçal) ve Nigella sativa (çörek otu), terapötik anti-enflamatuar etkileri yüzünden giderek artan ölçüde ilgi çekmektedir. Sunulan çalışmada piyasada bulunan topikal C. longa ve N. sativa içeren kremin (Dermacumin krem®), baş ve boyun dermatitli kedilerde günde iki kez tedavi edilmesinden 3 hafta sonra Feline Dermatitis Extent (FDE), Severity Index (SI) ve kaşıntı skorlarını önemli ölçüde azaltacağını varsayıyoruz. Bu amaçla daha önce tedavi görmemiş olan baş ve boyun dermatiti olan on sahipli kedi kullanıldı. FDE ve SI skorlarının 0. güne kıyasla 7. (P

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1. Favrot C: Feline non-flea induced hypersensitivity dermatitis: Clinical features, diagnosis and treatment. J Feline Med Surg, 15, 778-784, 2013. DOI: 10.1177/1098612X13500427

2. Noli C, Cena T: Comparison of FEDESI and SCORFAD scoring systems for the evaluation of skin lesions in allergic cats. Vet Dermatol, 26, 481-483, 2015. DOI: 10.1111/vde.12253

3. Schmidt V, Buckley LM, Mcewan NA, Rème CA, Nuttall TJ: Efficacy of a 0.0584% hydrocortisone aceponate spray in presumed feline allergic dermatitis: An open label pilot study. Vet Dermatol, 23, 11-16, 2012. DOI: 10.1111/j.1365-3164.2011.00993.x

4. Nuttall TJ, Steen RV, Cawood MI, Houghton CA: FC-49 feline dermatitis extent and severity index: A pilot study. Vet Dermatol, 15, 36, 2004. DOI: 10.1111/j.1365-3164.2004.411_49.x

5. Hill PB, Lau P, Rybnicek J: Development of an owner‐assessed scale to measure the severity of pruritus in dogs. Vet Dermatol, 18, 301-308, 2007. DOI: 10.1111/j.1365-3164.2007.00616.x

6. Suzuki M, Nakamura T, Iyoki S, Fujiwara, A, Watanabe Y, Mohri K, Isobe K, Ono K, Yano S: Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their antioxidative activities. Biol Pharm Bull, 28, 1438-1443, 2005. DOI: 10.1248/ bpb.28.1438

7. Zhang N, Li H, Jia J, He M: Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse. Cell Immunol, 298, 88-95, 2015. DOI: 10.1016/j.cellimm. 2015.09.010

8. Lee JH, Kim JW, Ko NY, Mun SH, Her E, Kim BK, Han JW, Lee HY, Beaven MA, Kim YM, Choi WS: Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol, 121, 1225-1231, 2008. DOI: 10.1016/j. jaci.2007.12.1160

9. Dwarampudi LP, Palaniswamy D, Nithyanantham M, Raghu PS: Antipsoriatic activity and cytotoxicity of ethanolic extract of Nigella sativa seeds. Pharmacogn Mag, 8, 268-272, 2012. DOI: 10.4103/09731296.103650

10. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC: Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol, 6, 1135-1142, 2006. DOI: 10.1016/j.intimp.2006.02.004

11. Noli C, Scarampella F: Prospective open pilot study on the use of ciclosporin for feline allergic skin disease. J Small Anim Pract, 47, 434-438, 2006. DOI: 10.1111/j.1748-5827.2006.00110.x

12. Vercelli A, Raviri G, Cornegliani L: The use of oral cyclosporin to treat feline dermatoses: A retrospective analysis of 23 cases. Vet Dermatol, 17, 201-206, 2006. DOI: 10.1111/j.1365-3164.2006.00514.x