GÜLCAN AVCI, CEVDET UĞUZ, İSMAİL BAYRAM, METİN ERDOĞAN, İSMAİL KÜÇÜKKURT, Mine Dosay AKBULUT, MEHMET ÖZDEMİR, ÖMER FARUK LENGER, Mesude İŞCAN, İnci TOGAN

Effects of nonylphenol on growth parameters and antioxidant defense system in japanese quails (Coturnix japonica)

Alkilfenol polietoksilatlar (AFEO) bileşikleri ve nonilfenol (NF) gibi AFEO türevleri, deterjanlar, ot ve böcek ilaçlarını da içeren pek çok organik bileşikte, genellikle antioksidan olarak kullanılmaktadır. Bu çalışmada, Japon Bıldırcınlarında büyüme, yumurta üretimi ve kuluçka randımanı üzerine nonilfenol etkileri araştırıldı. Ayrıca, nonilfenolün plazma vitamin düzeyleri ve malondialdehit (MDA) üzerine etkileri belirlendi. NF büyüme dönemindeki tüm deney guruplarında canlı ağırlık artışı (BWG) ve yemden yararlanma oranını (FCRG) etkilemezken, yumurta üretiminde önemli bir azalmaya neden olmaktadır (P

Anahtar Kelimeler:

kümes hayvanları, Japon bıldırcını, antioksidanlar, beta-karoten, kan kimyası, kan plazması, civciv, yumurta üretimi, etanol, yem çevirimi, yemden yararlanma, yem alımı, yem zenginleştiriciler, büyüme oranı, yumurtadan çıkmak, canlı ağırlık artışı, retinol, vitaminler

Japon Bıldırcınlarında (Coturnix japonica) büyüme parametreleri ve antioksidan savunma sistemine nonilfenolün etkileri

Alkylpehnol polyethoxylates (APEOs) and the derivatives of APEOs such as nonylphenol (NP) are generally used as anti-oxidants in many organic compounds including detergents, herbicides and pesticides. In this study, NP effects on growth, egg production and hatching in Japanese quails were investigated. Also, NP effects on plasma vitamin levels and malondialdehyde (MDA) were determined. NP does not affect body weight gain (BWG), feed consumption (FC) and feed conversion ratio for growth (FCRG) in all experimental groups in growing chicks, while it cause a significant decrease in egg production (EP) (P<0.01). Also, the present study showed that NP concentrations, 10, 100 and 500 μg NP in ethanol (ETOH) /kg-feed, exposure cause an increase in β-Carotene, Vitamin A and MDA levels (P<0.01). There is also significant rise in Vitamin C level induced by NP in all experimental groups (P<0.01). In conclusion, NP has dramatic effects on EP rate and anti-oxidant system in a concentration dependent manner in Japanese quails.

Keywords:

poultry, Japanese quails, antioxidants, beta-carotene, blood chemistry, blood plasma, chicks, egg production, ethanol, feed conversion, feed conversion efficiency, feed intake, feed supplements, growth rate, hatching, liveweight gain, retinol, vitamins,

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1. Nimrod AC, Benson WH: Environmental estrogenic effects of akylphenol etoxylates. Crit Rev Toxicol, 26, 335-364, 1996.
2. Bolt HM, Janning P, Michna H, Degen GH: Comparative assessment of endocrine modulators with oestrogenic activity. I. Definition of a hygiene-based margin of safety (HBMOS) for xenooestrogens against the background of European developments. Arch Toxicol, 74, 649-662, 2001.
3. Renner R: European bans on surfactant trigger transatlantic debate. Environ Sci Tech, 31, 316-320, 1997.
4. Blankenship AL, Coady K: Nonylphenol. In, Wexler P (Ed.): Encyclopedia of Toxicology. 2nd ed., pp. 260-263, Elsevier Academic Press, Oxford, 2005.
5. Montogomery-Brown J, Reinhard M: Occurrence and behavior of alkylphenol polyethoxylates in the environment. Environ Eng Sci, 20, 471-486, 2003.
6. Jobling S, Sumpter JP: Detergent components in sewage are weakly oestrogenic to fish, An in vitro study using rainbow trout (Onchorynchus mykiss) hepatocytes. Aquat Toxicol, 27, 361-372, 1993.
7. Skakkebaek NE, Meyts ERD, Jorgensen N, Carlsen E, Petersen PM, Giwercman A, Andersen AG, Jensen TK, Andersson AM, Muller J: Germ cell cancer and disorders of spermatogenesis: An environmental connection? APMIS, 106, 3-11, 1998.
8. Veeramachaneni DNR: Deteriorating trends in male reproduction, Idiopathic or Environmental? Anim Reprod Sci, 60-61, 121-130, 2000.
9. Hughes PJ, McLellan H, Lowes DA, Khan SZ, Bilmen JG, Tovey SC, Godfrey RE, Michell RH, Kirk CJ, Michelangeli F: Estrogenic alkylphenols induce cell death by inhibiting testis endoplasmic reticulum Ca2+ pumps. Biochem Biophysic Res Com, 277, 568-574, 2000.
10. Tapiero H, Nguyen Ba G, Tew KD: Estrogens and environmental estrogens. Biomed Pharmacother, 56, 36-44, 2002.
11. Salami RI: Replacement of poultry visceral offal meal for fish meal in layers’ diets. Niger J Anim Product, 24, 37-42, 1997.
12. Okon BI, Ogunmodede BK: Effects of replacing dietary fishmeal with periwinkle flesh on the performance of broiler chickens. Niger J Anim Product, 24, 37-42, 1995.
13. Abiola SS, Onunkwor EK: Replacement value of hatchery waste meal for fish meal in layer diets. Bioresour Technol, 95, 103-106, 2004.
14. Guenther K, Heinke V, Thiele B, Kleist E, Prast H, Raecker T: Endocrine disrupting nonylphenols are ubiquitous in food. Environ Sci Tech, 36, 1676-1680, 2002.
15. Yang DK, Ding WH: Determination of alkylphenolic residues in fresh fruits and vegetables by extractive steam distillation and gas chromatography-mass spectrometry. J Chromat A, 1088, 200-204, 2005.
16.Ye X, Kuklenyik ZL, Needham LL, Calafat AM: Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry. J Chromat B, 831, 110-115, 2006.
17.Ademollo N, Ferrara F, Delise M, Fabietti F, Funari E: Nonylphenol and octylphenol in human breast milk. Environ Int, 34, 984-987, 2008.
18.Lu CY, Ma YC: Oxidative stress associated with indoor air pollution and sick building syndrome-related symptoms among office workers in Taiwan. Inhal Toxicol, 19, 57-65, 2007.
19.Soares A, Guieysse B, Jefferson B, Cartmell E, Lester JN: Nonylphenol in the environment: A critical review on occurrence, fate, toxicity and treatment in wastewaters. Environ Int, 34, 1033-1049, 2008.
20.Kawaguchi M, Takahashia S, Seshimoa F, Sakui N, Okanouchia N, Itoa R, Inouea K, Yoshimuraa Y, Izumic SI, Makinoc T, Nakazawaa H: Determination of 4-tert.octylphenol and 4-nonylphenol in laboratory animal feed sample by stir bar sorptive extraction followed by liquid desorption and column-switching liquid chromatography-mass spectrometry with solid-phase extraction. J Chromat A, 1046, 83-88, 2004.
21.Razia S, Maegawab Y, Tamotsua S, Oishia T: Histological changes in immune and endocrine organs of quail embryos: Exposure to estrogen and nonylphenol. Ecotoxicol Environ Safety, 65, 364-371, 2006.
22.Yoshimura Y, Fujita M: Endocrine disruption in avian reproduction: The histological analysis. Av Poult Biol Rev, 16, 29-40, 2005.
23.Chitra KC, Latchoumycandane C, Mathur PP: Effect of nonylphenol on the antioxidant system in epididymal sperm of rats. Arch Toxicol, l76, 545-551, 2002.
24.Uguz C, Iscan M, Ergüven A, Isgor B, Togan I: The bioaccumulation of nonylphenol and its adverse effects on the liver of rainbow trout (Onchorynchus mykiss). Environ Res, 92, 262-270, 2003.
25.Uguz C, Togan I, Eroglu Y, Tabak I, Zengin M, Iscan M: Alkylphenol concentrations in two rivers of Turkey. Environ Toxicol Pharm, 14, 87-88, 2003.
26.Solé M, de Alda MJL, Castillo M, Porte C, Pedersen KL, Barcelo´ D: Estrogenicity determination in sewage treatment plants and surface waters from the Catalonian area (NE Spain). Environ Sci Tech, 34, 5076-5083, 2000.
27.Vaccaro E, Meucci V, Intorre L, Soldani G, Di Bello D, Longo V, Gervasi P G, Pretti C: Effects of 17-beta-estradiol 4nonylphenol and PCB 126 on the estrogenic activity and phase 1 and 2 biotransformation enzymes in male sea bass (Dicentrarchus labrax). Aquat Toxicol, 75, 293-305, 2005.
28.Livingstone DR: Contaminant-stimulated reactive oxygen species production and oxidative damage in aquatic organisms. Mar Pollut Bull, 42, 656-666, 2001.
29.Obata T: Environmental estrogen-like chemicals and hydroxyl radicals induced by MPTP in the striatum: A review. Neurochem Res, 27, 423-431, 2002.
30.Carrera EP, García-López A, del Pilar M, del Río M, Martínez-Rodríguez G, Solé M, Mancera JM: Effects of 17βestradiol and 4-nonylphenol on osmoregulation and hepatic enzymes in gilthead sea bream (Sparus auratus). Comp Biochem Physiol - Part C, 145, 210-217, 2007.
31.Kway A: A simple colorimetric method for ascorbic acid determination in blood plasma. Clin Chim Acta, 86, 153-157, 1978.
32.Suzuki J, Katoh NA: Simple and cheap methods for measuring serum vitamin-A in cattle using only a spectrophotometer. J Nip Juigaku Zasshi, 52, 1281-1283, 1990.
33.Draper HH, Hardley M: Malondialdehyde determination as index of lipid peroxidation. Meth Enzymol, 186, 421-431, 1990.
34.Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V: Method for the measurement of antioxidant activity in human fluids. J Clin Pathol, 54, 356-361, 2001.
35.Ergün G, Aktaş S: ANOVA modellerinde kareler toplamı yöntemlerinin karşılaştırılması. Kafkas Univ Vet Fak Derg, 15 (3): 481-484, 2009.
36.Snedecor GW, Cochran WG: Statistical Methods. Ames, A: Iowa State University Pres. 1980
37.Cox C: Nonylphenol and related chemicals. J Pest Reform, 16(1): 15-20, 2003.
38.Cunny HC, Mayes BA, Rosica KA, Trutter JA, Van Miller JP: Subchronic toxicity (90-day) study with para-nonylphenol in rats. Regul Toxicol Pharmacol, 26, 172-178, 1997.
39.Latendresse JR, Newbold RR, Weis CC, Delclos KB: Polycystic kidney induced in F1 sprague-Dawley rats fed para-nonylphenol in a soy-free casein-containing diet. Toxicol Sci, 62, 140-147, 2001.
40.Chen ML, Chang CC, Shen YJ, Hung JH, Guo BR, Chuang HY, Mao IF: Quantification of prenatal exposure and maternal-fetal transfer of nonylphenol. Chemos, 73, 239-245, 2008.
41.Vetillard A, Bailhache T: Effects of 4-n-nonylphenol and tamoxifen on sGnRH, estrogen receptor and vitellogenin gene expression in juvenile rainbow trout. Toxicol Sci, 1-28, 2004.
42.Okai Y, Sato EF, Higashi-Okai K, Inoue M: Enhancing effect of the endocrine disruptor para-nonylphenol on the generation of reactive oxygen species in human blood neutrophils. Environ Health Perspect, 112, 553-556, 2004.
43.Joreno DR: Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med, 9 (6): 515540, 1990.
44.Katz D, Mazor D, Dviansky A, Meyerstein N: Effect of radiation on red cell membrane and intra cellular oxidative defense system. Free Radic Res, 24 (3): 199-204, 1996.
45.Carr TP, Andersen CJ, Rudel LL: Enzymatic determination of triglyceride free cholesterol and total cholesterol in tissue lipid extracts. Clin Biochem, 26, 39-42, 1993.
46.Holley AE, Cheeseman KH: Measuring free radical reactions in vivo. Br Med Bull, 49, 494-505, 1993.
47.Moscio DP, Murphy EM, Sies H: Antioxidant defense systems: the role of carotenoids tocopherols and thiols. Am J Clin Nut, 53, 194-200, 1991.
48.Gong Y, Han XD: Nonylphenol-induced oxidative stress and cytotoxicity in testicular Sertoli cells. Reprod Toxicol, 22, 623-630, 2006.
49.Rucker BR, Morris JG: The vitamins. In, Kaneco JJ, Harvey JW, Bruss ML (Ed.): Clinical Biochemistry of Domestic Animals. 5th ed. Chapter 24, pp. 703-739, Academic Press Inc, California, 1997.
50.Gey KF: On the antioxidant hypothesis with regard to arteriosclerosis. Bibl Nutr Dieta, 37, 53 91, 1986.
51.Wefers H, Sies H: The protection of ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E. Eur J Biochem, 174, 353-357, 1988.
52.Gartner LP, Hiatt LJ: Color Textbook of Histology, 2nd ed., Saunders, Pennsylvania, 2001.
53.Aydogan M, Korkmaz A, Barlas N, Kolankaya D: The effect of vitamin C on bisphenol A, nonylphenol and octylphenol induced brain damages of male rats. Toxicol, 249, 35-39, 2008.