Determination of Potential Biomarker among Plasma Sphingosine-1-Phosphate, Total Sialic Acid and Adenosine Deaminase in Cattle with Naturally Infected Liver Cystic Echinococcosis
Bu çalışmanın amacı, doğal enfekte karaciğer kistik ekinokokozisli sığırlarda sfingozin-1-fosfat (S1P), total siyalik asit (TSA) ve adenozin deaminaz (ADA) için kan değerlerinin belirlenmesi ve böylece aralarından hangisinin muhtemel potansiyel bir biyomarker olabileceğinin belirlenmesidir. Parazitli olan (şiddetli kistik formu) ve sağlıklı sığırlardan kan örnekleri alındıktan sonra, belirtilen tüm biyokimyasal analizler yapıldı ve sonuçlar karşılaştırıldığında parazitli olan grupta anlamlı bir artış (P
Doğal Enfekte Karaciğer Kistik Ekinokokozisli Sığırlarda Plazma Sfingosin-1-fosfat, Total Sialik asit ve Adenozindeaminaz Arasından Potansiyel Biomarkerın Belirlenmesi
The purpose of this trial was to assay the alterations of some blood parameters such as sphingosine 1 phosphate (S1P), total sialic acid (TSA) and adenosine deaminase (ADA) and clarification of possible potential biomarker among them in naturally infected liver cystic echinococcosis in cattle. After observation of severe liver parasitic infestation (as cystic form) and blood sampling from parasitized and healthy ones, all selected biochemical analytes were clarified and results determined significant increase (P<=0.01) of aforementioned parameters in parasitized group rather than healthy ones. In conclusion, based on high sensitivity of TSA and ADA than S1P, they could be considered as potential biomarker in CE.
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