Determination of Potential Biomarker among Plasma Sphingosine-1-Phosphate, Total Sialic Acid and Adenosine Deaminase in Cattle with Naturally Infected Liver Cystic Echinococcosis

Bu çalışmanın amacı, doğal enfekte karaciğer kistik ekinokokozisli sığırlarda sfingozin-1-fosfat (S1P), total siyalik asit (TSA) ve adenozin deaminaz (ADA) için kan değerlerinin belirlenmesi ve böylece aralarından hangisinin muhtemel potansiyel bir biyomarker olabileceğinin belirlenmesidir. Parazitli olan (şiddetli kistik formu) ve sağlıklı sığırlardan kan örnekleri alındıktan sonra, belirtilen tüm biyokimyasal analizler yapıldı ve sonuçlar karşılaştırıldığında parazitli olan grupta anlamlı bir artış (P

Doğal Enfekte Karaciğer Kistik Ekinokokozisli Sığırlarda Plazma Sfingosin-1-fosfat, Total Sialik asit ve Adenozindeaminaz Arasından Potansiyel Biomarkerın Belirlenmesi

The purpose of this trial was to assay the alterations of some blood parameters such as sphingosine 1 phosphate (S1P), total sialic acid (TSA) and adenosine deaminase (ADA) and clarification of possible potential biomarker among them in naturally infected liver cystic echinococcosis in cattle. After observation of severe liver parasitic infestation (as cystic form) and blood sampling from parasitized and healthy ones, all selected biochemical analytes were clarified and results determined significant increase (P<=0.01) of aforementioned parameters in parasitized group rather than healthy ones. In conclusion, based on high sensitivity of TSA and ADA than S1P, they could be considered as potential biomarker in CE.

___

  • Ergin S, Saribas S, Yuksel P, Zengin K, Midilli K, Adas G, Arikan S, Aslan M, Uysal H, Caliskan R, Oner A, Kucukbasmaci O, Kaygusuz A, Mamal Torun M, Kocazeybek B: Genotypic characterisation of Echinococcus granulosus isolated from human in Turkey. Afr J Microbiol Res, 4, 551-555, 2010.
  • Latif AA, Tanveer A, Maqbool A, Siddiqi N, Kyaw-Tanner M, Traub RJ: Morphological and molecular characterisation of Echinococcus granulosus in livestock and humans in Punjab, Pakistan. Vet Parasitol, 170, 44-49, DOI: 10.1016/j.vetpar.2010.02.003
  • Pednekar RP, Gatne ML, Thompson RCA, Traub RJ: Molecular and morphological characterisation of Echinococcus from food producing animals in India. Vet Parasitol, 165, 58-65, 2009. DOI: 10.1016/j.vetpar. 06.021
  • Kowalski GM, Carey AL, Selathurai A, Kingwell BA, Bruce CR: Plasma sphingosine-1-phosphate is elevated in obesity. PLoS ONE, 8, e72449, DOI: 10.1371/journal.pone.0072449
  • NoferJ-R, MD, MBA: High density lipoprotein, sphingosine 1phosphate, and Atherosclerosis. J Clin Lipidology. 33, 48129, 2008. DOI: 10.1016/j. jacl.2007.11.002
  • Hanel P, Andreani P, Graler MH: Erythrocytes store and release sphingosine 1-phosphate in blood. FASEB J. 21, 1202-1209, 2007. DOI: 1096/fj.06-7433com
  • Takuwa Y, Ikeda H, Okamoto Y, Takuwa N, Yoshioka K: Sphingosine- phosphate as a mediator involved in development of fibrotic diseases. Biochim Biophys Acta, 1831, 185-192, 2013. DOI: 10.1016/j.bbalip. 06.008
  • Guzel M, Askar TK, Kaya G, Atakisi E, Erbil Avci G: Serum sialic acids, total antioxidant capacity, and adenosine deaminase activity in cattle with therliriosis and anaplasmosis. Bull Vet Inst Pulawy, 52, 227-230, 2008.
  • Citil M, Gunes V, Karapehlivan M, Atalan G, Marasli S: Evaluation of serum sialic acid as an inflammation marker in cattle with traumatic reticulo peritonitis. Rev Med Vet, 155, 389-392, 2004.
  • Yurtsevan S, Uysal H: Decreased serum sialic acid, albumin-globulin ratio and total protein levels in cattle heavily infected with Theileria annulata. Ankara Üniv Vet Fak Derg, 56, 141-144, 2009.
  • Chrostek L, Cylwik B, Panasiuk A, Brodowska-Adamusiak D, Gruszewska E: Lipid-bound sialic acid (LSA) in liver diseases of different etiologies. Annal Hepatology J, 10, 150-154, 2011.
  • Gopi A, Madhavan SM, Sharma SK, Sahn SA: Diagnosis and treatment of tuberculosis pleural effusion in 2006. Chest, 131, 880-889, DOI: 10.1378/chest.06-2063
  • Aydin I, Bulbul T, Polat ES, Yazar E: Serum antioxidant status and adenosine deaminase activity during the gestational period of sheep. Rev Méd Vét, 161, 479-484, 2010.
  • Atakisi E, Karapehlivan M, Atakisi O, Kontas T, Marasli S: Adenosine deaminase and biochemical liver function tests in the dermatophytic cattle. Bull Vet Inst Pulawy, 50, 481-483, 2006.
  • Sydow G: A simplified quick method for determination of sialic acid in serum. Biomed Biochim Acta, 44, 1721-1723, 1985.
  • Pönniö M, Alho H, Nikkari ST, Olsson U, Rydberg U, Sillanaukee P: Serum sialic acid in a random sample of the general population. Clin Chem, 45, 1842-1849, 1999.
  • Stefenelli N, Klotz H, Engel A, Bauer P: Serum sialic acid in malignant tumors, bacterial infections and chronic liver diseases. J Cancer Res Clin Oncol, 109, 55-59, 1985. DOI: 10.1007/BF01884255
  • Goetzl EJ, Rosen H: Regulation of immunity by lyso sphingolipids and their G-protein-coupled receptors. J Clin Invest, 114, 1531-1537, DOI: 10.1172/JCI200423704
  • Hait NC, Oskeritzian CA, Paugh SW, Speiegel S: Sphingosine kinase, sphingosine 1-phosphate, apoptosis and disease. Biochim Biophs Acta, 1758, 2016-2026, 2006. DOI: 10.1016/j.bbamem.2006.08.007
  • Graeler M, Goetzl EJ: Activation - regulated expression and chemotactic function of sphingosine 1- phosphate receptors in mouse splenic T cells. FASEB J, 16, 1874-1878, 2002. DOI: 10.1096/fj.02-0548com
  • Zheng Y, Kong Y, Goetzl EJ: Lysophosphatidic acid receptor selective effects on jurkat T cell migration through a matrigel model basement membrane. J Immunol, 166, 2317-2322, 2001. DOI: 10.4049/ jimmunol. 4.2317
  • Li C, Jiang X, Yang L, Liu X, Yue S, Li L: Involvement of sphingosine phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. Am J Pathol, 175, 1464-1472, 2009. DOI: 10.2353/ajpath.2009.090037
  • Ikeda H, Ohkawa R, Watanabe N, Nakamura K, Kume Y, Nakagawa H, Yoshida H, Okubo S, Yokota H, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Koike K, Yatomi Y: Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. Clin Chim Acta, 411, 765-770, 2010. DOI: 1016/j.cca.2010.02.063
  • Pappu R, Schwab SR, Cornelissen I: Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science, 316, 295-298, 2007. DOI: 10.1126/science.1139221
  • Yatomi Y, Ruan F, Hakomori S, Igarashi Y: Sphingosine-1-phosphate: A platelet activating sphingolipid released from agonist-stimulated human platelets. Blood, 86, 193-202, 1995.
  • Toghill PJ, Green S: Platelet dynamics in chronic liver disease using the 111Indium oxine label. Gut, 24, 49-52, 1983.
  • Isik S, Karaman U, Raika Kiran T, Özer A: Serum Adenosine deaminase (ADA) levels in surgically treated hydatid cyst patients. Sci Res Essays, 6, 3101-3102, 2011.
  • Juma ASM, Al-Jeboori TI, Shubber EK: Adenosine deaminase activity of erythrocytes from mice experimentally infected with secondary hydatid disease. Dirasat Med Biol Sci, 2, 110-116, 2000.
  • Umaramani G, Sameera K, Suryanarayana D: Evaluation of serum adenosine deaminase activity in viral hepatitis. Int J Biol Med Res. 3 (3): 2019, 2012.
Kafkas Üniversitesi Veteriner Fakültesi Dergisi-Cover
  • ISSN: 1300-6045
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1995
  • Yayıncı: Kafkas Üniv. Veteriner Fak.
Sayıdaki Diğer Makaleler

An Investigation on the Relationship between the AzoospermiaLike (DAZL) Gene mRNA Expression and the Infertility in Male Cattle-Yak

Yincang HAN, Yong FU

Isolation and Identification of High Lactic Acid Producer Bacteria from Forage and Their Silages Grown in Different Ecologies

MUSTAFA KIZILŞİMŞEK, MUSTAFA KÜSEK, YEKTA GEZGİNÇ, ADEM EROL

Molecular Prevalence and Haematology of Tropical Theileriosis in Cholistani Cattle from Nomadic Herds of the Cholistan Desert, Pakistan

Zaka SAEED, Furhan IQBAL, Mureed HUSSAIN, Rehan Sadiq SHAIKH, Umer FAROOQ, Atif AKBAR, Muhammad GULSHER, Muhammad Mazhar AYAZ, Syed Aamir MAHMOOD, Muhammad ALI, Münir AKTAŞ

Isolation and Characterization of Olfactory Stem Cells from Canine Olfactory Mucosa

Korhan ALTUNBAŞ, Mustafa Volkan YAPRAKÇI, Sefa ÇELIK

The Isolation of Dichelobacter nodosus and Identification by PCR from Ovine Footrot in Kars District, Turkey

ÖZGÜR ÇELEBİ, Salih OTLU, FATİH BÜYÜK, CELAL ŞAHİN ERMUTLU, ALİYE GÜLMEZ SAĞLAM, Elif ÇELİK, Doğan AKÇA, MİTAT ŞAHİN

Semen Characteristics and Cardiac Enzymes in Healthy Male Cats Fed with Commercial Cat Food Containing Yucca schidigera

Handan AYDIN VURAL, ALPER BARAN, HURİYE BALCI

Determination of Iron Deficiency Anemia in Helicobacter Infected Dogs

YÜCEL MERAL, Duygu DALĞIN, Mehtap ÜNLÜ SÖĞÜT

Serum IL-1?, IL-6, IL-10 and TNF-? Levels in Thyroidectomized Rats

SİNAN KANDIR, Ercan KESKIN

Why Systematic Examination is Important in Diagnosis of Eye Diseases? Lacrimal Punctal Atresia of a Dog Treated When He Reaches the Age of 15 Months

Sırrı AVKİ, KÜRŞAD YİĞİTARSLAN

Determination of Potential Biomarker among Plasma Sphingosine-1-Phosphate, Total Sialic Acid and Adenosine Deaminase in Cattle with Naturally Infected Liver Cystic Echinococcosis

VAKILI Azad, Kaveh AZIMZADEH, Sohrab RASOULI