Control of bovine viral diarrhoea infections through vaccination

BVDV enfeksiyonlarına karşı aşılamanın asıl amacı sığırlarda her iki BVDV-1 ve BVDV-2 genotipe ait virüslere koruyucu bağışıklığın oluşması ve gebelik sürecinde fötüsun enfeksiyonunun önlenmesi kadar BVDV- 2 genotipine ait bazı virüsler tarafından oluşturulan öldürücü enfeksiyonların da önlenmesidir. Günümüze kadar sadece bir kaç aşı ve bazı aşılama stratejileri yüksek oranda başarılı olmuştur. Canlı ve atenüye edilmiş BVDV aşıları daha iyi koruma sağlamakla birlikte, güvenlik sorunları yaratmaktadır. İnaktive aşıların da geniş spektrumda koruma sağladıkları konusunda tereddütler bulunmaktadır. BVDV kontrolü için halen daha etkili, yeni jenerasyon aşı geliştirilmesine ihtiyaç vardır.

Anahtar Kelimeler:

aşı(hayvan), aşı geliştirme, antijen varyasyonu, ishal, sığır diyare virüsü

Bovine viral diarrhoea enfeksiyonlarının aşılama ile kontrolü

The main goal of BVDV vaccination is to induce adequate immunity in dams for protecting the infection of foetuses against both genotypes of BVDV-1 and BVDV-2 viruses during pregnancy and thus preventing the establishment of persistent infections as well as preventing severe postnatal infections caused by BVDV-2. The most important problem for BVDV vaccine development is the existence of diversity of BVDV isolates in worldwide. So far, a few BVDV vaccines and vaccination strategies have been given good results for preventing transplacental infections. Live-attenuated BVDV vaccines are better for protection but they have safety concerns. Inactivated vaccines are questionable for inducing adequate broad immune response. There is still a necessity for the development of a better and a novel vaccine for the control of BVDV infections.

Keywords:

vaccines, vaccine development, antigenic variation, diarrhoea, bovine diarrhoea virus,

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Heinz FX, Collett MS, Purcell RH, Gould, EA, Howard CR, Houghton, M, E, Moormann R J M, Rice CM and Thiel H-J: Family Flaviviridae. In van Regenmortel MHV, Fauget CM, Bishop EB, Carstens, MK, Estes SM, Lemon J, Maniloff MA, Mayo DJ, McGeoch CR, Pringle and Wickner RB (Eds): Virus taxonomy. Seventh Report of the International Committee on Taxonomy of Viruses. Academic Press, San Diego, Calif, 2000.
Becher P, Avalos Ramirez R, Orlich M, Cedillo Rosales S, Konig M, Schweizer M, Stalder H, Schirrmeier H, Thiel HJ: Genetic and antigenic characterization of novel pestivirus genotypes: implications for classification. Virology, 311 (1): 96-104, 2003.
Becher P, Orlich M, Kosmidou A, Konig M, Baroth M, Thiel HJ: Genetic diversity of pestiviruses: identification of novel groups and implications for classification. Virology, 262 (1): 64-71, 1999.
Baker JC: The clinical manifestations of bovine viral diarrhea infection. Vet Clin North Am Food Anim Pract, 11 (3): 425- 449, 1995.
Netletton PF, Entrican G: Ruminant pestiviruses. Br Vet J, 151 (6): 615-642, 1995.
Houe H: Epidemiological features and economical importance of bovine virus diarrhoea virus (BVDV) infections. Vet Microbiol, 64 (2-3): 89-107, 1999.
Pellerin C, van den Hurk J, Lecomte J, Tijssen P: Identification a new group bovine viral diarhea virus strains associated with severe outbreaks and high mortalities. Virology, 203, 260-269, 1994.
Ridpath JF, Bolin SR, Dubovi EJ: Segregation of bovine viral diarrhea virus in to genotypes. Virology, 205, 66-74, 1994.
Deregt D, Loewen KG: Bovine viral diarrhea virus: biotypes and disease. Can Vet J, 36, 371-377, 1995.
Ridpath JF, Neill JD, Frey M, Landgraf JG: Phylogenetic, antigenic and clinical characterization of type 2 BVDV from North America. Vet Microbiol, 77 (1-2): 145-55, 2000.
Meyers G, Thiel HJ: Molecular characterization of pestiviruses. Adv Virus Res, 47, 53-118, 1996.
Bolin SR: The pathogenesis of mucosal disease. Vet Clin North Am Food Anim Pract, 11 (3): 489-500, 1995.
Brock KV: The persistence of bovine viral diarrhea virus. Biologicals, 31 (2): 133-5, 2003.
Nagai M, Ito T, Sugita S, Genno A, Takeuchi K, Ozawa T, Sakoda Y, Nishimori T, Takamura K, Akashi H: Genomic and serological diversity of bovine viral diarrhea virus in Japan. Arch Virol, 146 (4): 685-96, 2001.
Flores EF, Gil LH, Botton SA, Weiblen R, Ridpath JF, Kreutz LC, Pilati C, Driemeyer D, Moojen V, Wendelstein AC: Clinical, pathological and antigenic aspects of bovine viral diarrhea virus (BVDV) type2 isolates identified in Brazil. Vet Microbiol, 77 (1-2): 175-83, 2000.
Vilcek S, Durkovic B, Bobakova M, Sharp G, Paton DJ: Identification of bovine viral diarrhoea virus 2 in cattle in Slovakia. Vet Rec, 151 (5): 150-2, 2002.
Wakeley PR, Turner JL, Ibata G, King DP, Sandvik T, Howard P, Drew TW: Characterisation of a type 2 bovine viral diarrhoea virus isolated from cattle in the UK. Vet Microbiol, 102 (1-2): 19-24, 2004.
Brownlie J: The pathways for bovine virus diarrhoea virus biotypes in the pathogenesis of the disease. Arch Virol suppl, 3, 79-96, 1991.
Lindberg AL: Bovine viral diarrhoea virus infections and its control. A review. Vet Q, 25 (1): 1-16, 2003.
Tautz N, Thiel HJ: Cytopathogenicity of pestiviruses: Cleavage of bovine viral diarrhea virus NS2-3 has to occur at a defined position to allow viral replication. Arch Virol, 148 (7): 1405- 1412, 2003.
Brownlie J, Clarke MC, Hooper LB, Bell GD: Protection of the bovine fetus from bovine viral diarrhoea virus by means of a new inactivated vaccine. Vet Rec, 137 (3): 58-62, 1995.
Patel JR, Shilleto RW, Williams J, Alexander DC: Prevention of transplacental infection of bovine foetus by bovine viral diarrhoea virus through vaccination. Arch Virol, 147 (12): 2453-63, 2002.
Greiser-Wilke I, Grummer B, Moennig V: Bovine viral diarrhoea eradication and control programmes in Europe. Biologicals, 31 (2): 113-8, 2003.
Barkema HW, Bartels CJ, van Wuijckhuise L, Hesselink JW, Holzhauer M, Weber MF, Franken P, Kock PA, Bruschke CJ, Zimme GM: Outbreak of bovine virus diarrhea on Dutch dairy farms induced by a bovine herpesvirus 1 marker vaccine contaminated with bovine virus diarrhea virus type 2. Tijdschr Diergeneeskd, 126 (6): 158-65, 2001.
Beer M, Hehnen HR, Wolfmeyer A, Poll G, Kaaden OR, Wolf G: A new inactivated BVDV genotype I and II vaccine. An immunisation and challenge study with BVDV genotype I. Vet Microbiol, 77, 195-208, 2000.
Kovacs F, Magyar T, Rinehart C, Elbers K, Schlesinger K, Ohnesorge WC: The live attenuated bovine viral diarrhea virus components of a multi-valent vaccine confer protection against fetal infection. (2003). Vet Microbiol, 96 (2): 117-31, 2003.
Fairbanks KK, Rinehart CL, Ohnesorge WC, Loughin MM, Chase CC: Evaluation of fetal protection against experimental infection with type 1 and type 2 bovine viral diarrhea virus after vaccination of the dam with a bivalent modified-live virus vaccine. J Am Vet Med Assoc, 225 (12): 1898-904, 2004.
Bolin SR: Control of Bovine Viral Diarrhoea Infection by use of Vaccination. Vet Clin North Am Food Anim Prac, 11 (3): 615- 625, 1995.
van Oirschot JT, Bruschke CJ, van Rijn PA: Vaccination of cattle against bovine viral diarrhoea. Vet Microbiol, 64 (2-3): 169-83, 1999.
Howard CJ, Clarke MC, Sopp P, Brownlie J: Systemic vaccination with inactivated bovine virus diarrhoea virus protects against respiratory challenge. Vet Microbiol, 42 (2- 3): 171-179, 1994.
Brownlie J, Clarke MC, Hooper LB, Bell GD: Protection of the bovine fetus from bovine viral diarrhoea virus by means of a new inactivated vaccine. Vet Rec, 137(3): 58-62, 1995.
Potgieter LN: Immunology of bovine viral diarrhea virus. Vet Clin North Am Food Anim Pract, 3, 501-520, 1995.
Deregt D, Bolin SR, van den Hurk J, Ridpath JF, Gilbert SA: Mapping of a type 1-specific and type-common epitope on the E2 (gp53) protein of bovine viral diarrheoa with neutralization escape mutants. Virus Res, 53, 81-90, 1998.
Deregt D, van Rijn, P.A, Wiens TY, van den Hurk J: Monoclonal antibodies to the E2 protein of a new genotype (type 2) of bovine viral diarrhea virus define three antigenic domains involved in neutralization. Virus Res, 57 (2): 171-81, 1998.
Couvreur B, Letellier C, Collard A, Quenon P, Dehan P, Hamers, C, Pastoret, PP, Kerkhofs, P: Genetic and antigenic variability in bovine viral diarrhea virus (BVDV) isolates from Belgium. Virus Res, 85 (1): 17-28, 2002.
Fulton RW, Ridpath JF, Confer, AW, Saliki, JT, Burge LJ, Payton ME: Bovine viral diarrhoea virus antigenic diversity: impact on disease and vaccination programmes. Biologicals, 31 (2): 89-95, 2003.
Hamers C, Di valentine E, Lecomte C, Lambot M, Joris E, Genicot B, Pastoret P: Virus neutralising antibodies against 22 bovine viral diarrhoea virus isolates in vaccinated calves. Vet J, 163 (1): 61-7, 2002.
Patel JR, Didlick S, Quinton J: Variation in immunogenicity of ruminant pestiviruses as determined by the neutralisation assay. Vet J, 169 (3): 468-72, 2005.
Patel JR, Shilleto RW, Williams J, Alexander DC: Prevention of transplacental infection of bovine foetus by bovine viral diarrhoea virus through vaccination. Arch Virol, 147 (12): 2453-2463, 2002.
Vilcek S, Drew TW, McGoldrick A, Paton DJ: Genetic typing of bovine pestiviruses from England and Wales. Vet Microbiol, 69 (4): 227-37, 1999.
Fairbanks K, Schnackel J, Chase CC: Evaluation of a modified live virus type-1a bovine viral diarrhea virus vaccine (Singer strain) against a type-2 (strain 890) challenge. Vet Ther, 4 (1): 24-34, 2003.
Makoschey B, Janssen, MG, Vrijenhoek MP, Korsten JH, Marel P: An inactivated bovine virus diarrhoea virus (BVDV) type 1 vaccine affords clinical protection against BVDV type 2. Vaccine, 19(23-24): 3261-8, 2001.
Frey HR, Eicken K, Grummer B, Kenklies S, Oguzoglu TC, Moennig V: Foetal Protection against Bovine Virus Diarrhoea Virus after Two-step Vaccination. J Vet Med B Infect Dis Vet Public Health, 49 (10): 489-493, 2002.
Dean HJ, Hunsaker BD, Bailey OD, Wasmoen T: Prevention of persistent infection in calves by vaccination of dams with noncytopathic type-1 modified-live bovine viral diarrhea virus prior to breeding. Am J Vet Res, 64 (5): 530-537, 2003.
Ridpath J, Bolin SR: Delayed Onset Postvaccinal mucosal Disease as a Result of Genetic Recombination between Genotype 1 and Genotype 2 BVDV. Virology, 212, 259-262, 1995.
Becher P, Orlich M, Thiel HJ: RNA recombination between persisting pestivirus and a vaccine strain: generation of cytopathogenic virus and induction of lethal disease. J Virol, 75 (14): 6256-64, 2001.
Burgu İ, Özkul A: Detection of bovine viral diarrhea virus following field in cattle and their foetuses in Turkey. Dtsch Tierarztlchl Wschr, 100, 361-363, 1993
Burgu I, Alkan F, Özkul A, Yesilbag K: Türkiyede sığırlarda persiste BVD enfeksiyonu. A Ü Vet Fak Derg, 46, 169-177, 1999.
Yıldırım Y: Kuzeydoğu Anadolu Bölgesindeki sığırlarda Mavidil (BT), IBR, PI-3, EBL ve BVD enfeksiyonlarının seroprevalansı. Doktora tezi, Sağlık Bilimleri Enstitüsü, Ankara Üniversitesi, 2003.
Burgu I, Alkan F, Ozkul A, Yesilbag K, Karaoglu T, Gungor B: Türkiye’de süt sığırcılığı işletmelerinde bovine viral diarrhea virus (BVDV) enfeksiyonunun epidemiyolojisi ve kontrolü. A Ü Vet Fak Derg, 50, 127-133, 2003.
Fulton RW, Ridpath, JF, Saliki, JT, Briggs, RE, Confer, AW, Burge, LJ, Purdy, CW, Loan, RW, Duff, GC, Payton, ME: Bovine viral diarrhea virus (BVDV) 1b: predominant BVDV subtype in calves with respiratory disease. Can J Vet Res, 66, 181-190, 2002.
Bolin SR, Ridpath JF: Glycoprotein E2 of bovine viral diarrhea virus expressed in insect cells provides calves limited protection from systemic infection and disease. Arch Virol, 141 (8): 1463-77, 1996.
Harpin S, Hurley DJ, Mbikay M, Talbot B, Elazhary YJ: Vaccination of cattle with a DNA plasmid encoding the bovine viral diarrhoea virus major glycoprotein E2. J Gen Virol, 80 (12): 3137-44, 1999.
Nobiron I, Thompson I, Brownlie J, Collins ME: Cytokine adjuvancy of BVDV DNA vaccine enhances both humoral and cellular immune responses in mice. Vaccine, 19 (30): 4226- 35, 2001.
Nobiron I, Thompson I, Brownlie J, Collins ME: DNA vaccination against bovine viral diarrhoea virus induces hu-moral and cellular responses in cattle with evidence for pro-tection against viral challenge. Vaccine, 16; 21(17-18): 2082-92, 2003.
Makoschey B, Becher P, Janssen MG, Orlich M, Thiel HJ, Lutticken D: Bovine viral diarrhea virus with deletions in the 5'-nontranslated region: reduction of replication in calves and induction of protective immunity. Vaccine, 22 (25-26): 3285-94, 2004.
Liang R, van den Hurk JV, Babiuk LA, van Duruen Littel-van den Hurk S: Priming with DNA encoding E2 and boosting with E2 protein formulated with CpG oligodeoxynucleotides induces strong immune responses and protection from Bovine viral diarrhea virus in cattle. J Gen Virol, 87 (10): 2971- 2982, 2006.
Kalaycıoğlu AT: Preliminary studies on the identification of vaccinal mimotopes of bovine viral diarrhoea virus using combinatorial peptide libraries. PhD thesis, London University, London, United Kingdom, 2006.