ALİ HAYDAR KIRMIZIGÜL, Şemistan KIZILTEPE, ERHAN GÖKÇE, FATİH BÜYÜK, MİTAT ŞAHİN, EKİN EMRE ERKILIÇ

Clinical effectiveness of ivermectin on bovine dermatophytosis

Bu çalışma, dermatofitozisli sığırlarda ivermektinin klinik etkinliğini araştırma amacıyla yapıldı. Çalışmanın materyalini, klinik ve mikrobiyolojik olarak dermatofitozis tanısı konulan, 3-14 aylık, 20 deneme (Grup I), 10 kontrol (Grup II) olmak üzere toplam 30 genç sığır oluşturdu. Hayvanların klinik durumları; lezyonların lokalizasyonu, büyüklüğü, sayıları ve kondisyonlarına göre, hafif (+), orta (++) ve şiddetli (+++) olarak skorlandırıldı. Çalışma süresince deneme ve kontrol grubundaki hayvanların bakım, besleme ve barınak koşullarında herhangi bir değişiklik yapılmadı. Grup I’deki hayvanlara 0.2 mg/kg dozunda deri altı yolla bir kez uzun etkili ivermektin uygulandı. Grup II’deki hayvanlara ise herhangi bir tedavi uygulanmayarak kontrol olarak tutuldu. Tedaviyi takiben hayvanlar 45 gün gözlemlendi. Grup II’deki hayvanlarda herhangi bir iyileşme görülmezken, grup I’deki 18 hayvanın (%90) iyileştiği gözlemlendi. Bu çalışma ile yaygın olarak antiparaziter amaçla kullanılan ve aynı zamanda immun sistemi aktive ettiği bilinen ivermektin ilk kez ruminantlarda dermatofitozisin tedavisinde kullanılmış ve tedavide %90 oranında başarı elde edilmiştir. Bu sonuçlarla ivermektinin sığır dermatofitozisinin tedavisinde klinik olarak oldukça etkili olduğu kanısına varıldı.

Anahtar Kelimeler:

ivermektin, sığır, klinik muayene, dermatomikoz, dermatofitler, hastalık kontrolü, ilaç tedavisi, bağışıklık sistemi

Dermatofitozisli sığırlarda ivermektinin klinik etkinliği

In the present study, clinical effectiveness of ivermectin on bovine dermatophytosis was evaluated. The material of the study consisted of 30 cattle, 20 experimental (Group I) and 10 control (Group II) animals aged between 3-14 months, diagnosed as dermatophytosis following clinical examination and microbiology. Clinical status of cases were scored on localization, size and number of lesions and condition of the cases were as follows mild (+), moderate (++) and severe (+++). During the study period, farm management practices of the animals were not changed. A single long acting injection of ivermectin at a dose of 0.2 mg/kg was subcutaneously administered to the animals in Group I. Animals in Group II served as a control and received no treatment. Following medical treatment and 45 days of observation period, recovery was recorded 18 animals from Group I (90%). No recovery was observed in the Group II. This study indicated that, ivermectin which is widely used as antiparasiter medicine, activate the immune system. For this reason, in the present study, first time, ivermectin was used in the treatment of dermatophytosis in ruminants with a 90% of recovery rate. These findings show that ivermectin can be used succesfully in the treatment of dermatophytosis infection in cattle.

Keywords:

ivermectin, cattle, clinical examination, dermatomycoses, dermatophytes, disease control, drug therapy, immune system,

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