SAVAŞ YILDIZ, Örsan GÜNGÖR, P. Barbaros TUNCER, UMUT TAŞDEMİR, Halil EROL, CİHAN KAÇAR, M. Numan BUCAK

Ankara tekelerinde uzun etkili GnRH analoğu deslorelin'in seksüel aktivite üzerine etkileri

Sunulan bu araştırma ile son yıllarda bazı hayvan türlerinde seksüel aktivitenin ertelenmesi amacıyla kullanılan, fakat tekelerdeki etkisi ortaya konmamış olan GnRH agonisti deslorelinin plazma testesteron düzeyleri ve testis ölçüleri üzerine etkileri ve yan etkilerinin araştırılması amaçlandı. Çalışmada kullanılan hayvan materyalini Lalahan Hayvancılık Merkez Araştırma Enstitüsü tarafından sağlanan 2-5 yaşlı 12 baş Ankara tekesi oluşturdu ve tekeler her grupta 6 baş bulunacak şekilde iki gruba ayrıldı. Etkisi araştırılacak olan GnRH anoloğu deslorelin, 6 baş tekenin (Grup I, n=6) kulak derisi altına yerleştirildi ve implantlar burada 15 gün süre ile bırakıldı. Kontrol grubundaki tekelere ise (Grup II, n=6) placebo uygulandı. İmplantların çıkarılmasından sonra tüm hayvanlarda testis ve epididimis ölçüleri, ayrıca plazma testosteron düzeyi değerleri belirlendi. İmplantlar çıkarılmadan önce sadece 3. günde elde edilen testosteron değerleri açısından deslorelin (4.08±1.9 ng/ml) ve kontrol grubu (6.79±5.0 ng/ml) arasında istatistiksel farkın önemli olduğu tespit edildi (P

Anahtar Kelimeler:

Angora(keçi), GnRH, agonistler, kan plazması, erkeç, keçi ırkları, erkek hayvanlar, testis, testosteron

The effect of deslorelin, GnRH analogue with long acted on sexual activities in angora bucks

In this study, it was aimed to investigate the effect of deslorelin, a GnRH analogue -which can postpone the sexual activity in some male animals-on the levels of plasma testosteron, testes size and side effects in Angora Bucks. As a animal material, 12 Angora male goat aged between 2-5 years and provided by Lalahan Animal Research Center. Animal were divided two equal groups. Deslorelin implants were replaced under the ear skin of goats (Group I, n=6) and left for 15 days. The animals of control group (Group II, n=6) had placebo treatment. After removal of implants, testicular size and epididiymal and plasma testosteron levels were determined. Plasma testosteron levels of deslorelin (4.08±1.9 ng/ml) estimated on 3rd day before implant removal was significantly higher than the those of control group (6.79±5.0 ng/ml) (P<0.05). Plasma testosteron levels estimated on day 6 th, (P<0.01), day 9th (P<0.05), day 12th (P<0.01), day 18th (P<0.05) and day 21st (P<0.05) after removal of implant were significantly different between the groups. The values of testicular volume, lenght, diameter, radius and epididiymal measurement were not significantly different (P>0.05) in groups. No side effects were seen during the deslorelin treatment, and sexual activity returned to normal after removing of implants, therefore it was suggetsed that deslorelin could be safely used as a succesful antifertility agent.

Keywords:

Angora, GnRH, agonists, blood plasma, bucks, goat breeds, male animals, testes, testosterone,

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