Gokhan TAZEGUL, Melek KARAKURT ERYILMAZ, Fatma YALÇIN MÜSRİ, Betül ÜNAL, Gülsüm Özlem ELPEK, Hasan Şenol COŞKUN

Senkron Meme ve Mide Kanserlerini Taklit Eden Metastatik İnvazif Lobüler Meme Karsinomu

Memenin lobüler karsinomunun mide metastazı küçük yuvarlak hücreler olarak gözlenir, lineer kordonlar yapar ve midenin taşlı yüzük hücreli kanserinden ayrımı zordur. Bu ayırıcı tanı hastanın tedavisini uygun şekilde planlamada hayati öneme sahiptir. Bu vakada başlangıçta senkron gastrik ve meme karsinomu tanısı konulan, sonrasında metastatik invazif lobüler karsinom tanısı alan olgunun seyri ve bu konuda tanı ve tedavi yaklaşımlarının literatür tartışması sunulmuştur.

Anahtar Kelimeler:

meme kanseri, ikinci primer, mide kanseri

Metastatic Invasive Lobular Breast Carcinoma Mimicking Synchronous Breast and Gastric Cancers

Metastatic lobular carcinoma to stomach is seen as small round cells in linear cords within the normal tissue and it is not easily differentiated from signet cell adenocarcinoma of the stomach. Differentiating synchronous primary gastric carcinoma from metastatic involvement is vital in accurately planning treatment. Herein, we report a case of gastric metastatic invasive lobular breast carcinoma initially misdiagnosed as synchronous gastric and breast carcinoma and discuss the diagnostic and therapeutic challenges.

Keywords:

breast neoplasms, second primary, stomach neoplasms,

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1. Rachan Shetty KS, Challa VR, Lakshmaiah KC, Champaka G, Babu KG. Gastric metastases from breast cancer: A report of two cases and review of literature. J Cancer Res Ther 2015;11:660.
2. Zhang B, Copur-Dahi N, Kalmaz D, Boland BS. Gastrointestinal manifestations of breast cancer metastasis. Dig Dis Sci 2014;59:2344–6.
3. Ellis MC, Mason T, Barnett J, Kiesow LL, Vetto JT. Gastric malignancies in breast cancer survivors: pathology and outcomes. Am J Surg 2009;197:633–636.
4. Buka D, Dvořák J, Richter I, Hadzi ND, Cyrany J. Gastric and Colorectal Metastases of Lobular Breast Carcinoma: A Case Report. Acta Medica (Hradec Kralove)2016;59:18–21.
5. Takeuchi H, Hiroshige S, Yoshikawa Y, Kusumoto T, Muto Y. A case of synchronous metastasis of breast cancer to stomach and colon. Anticancer Res 2012;32:4051–5.
6. Ambroggi M, Stroppa EM, Mordenti P, Biasini C, Zangrandi A, Michieletti E, et al. Metastatic breast cancer to the gastrointestinal tract: Report of five cases and review of the literature. Int J Breast Cancer 2012;2012:439023.
7. Schwarz RE, Klimstra DS, Turnbull ADM. Metastatic breast cancer masquerading as gastrointestinal primary. Am J Gastroenterol 1998;93:111–114.
8. Zuhair AR, Maron AR. Occult bilateral invasive lobular carcinoma of the breast presenting as gastroduodenal metastases: a case report. Breast Dis 2015;35:63–5.
9. Matsui M, Kojima O, Kawakami S, Uehara Y, Takahashi T. The prognosis of patients with gastric cancer possessing sex hormone receptors. Surg Today 1992;22:421–5.
10. Kim WH, Gomez-Izquierdo L, Vilardell F, Chu KM, Soucy G, Dos Santos LV, et al. HER2 Status in Gastric and Gastroesophageal Junction Cancer: Results of the Large, Multinational HER-EAGLE Study. Appl Immunohistochem Mol Morphol. Epub 2016 Aug 3.
11. Jones GE, Strauss DC, Forshaw MJ, Deere H, Mahedeva U, Mason RC. Breast cancer metastasis to the stomach may mimic primary gastric cancer: report of two cases and review of literature. World J Surg Oncol 2007;5:75.