Nazan DOLU, Seval KELOĞLAN MÜSÜROĞLU, Leyla ŞAHİN, Kürşad ÜNLÜHİZARCI, Mustafa Tayfun TURAN

Hipertiroidilerde Reaksiyon Zamanının Oddball Paradigması ile Araştırılması

Amaç: Tiroid hormonları beyinde fizyolojik ve bilişsel işlevler için oldukça önemlidir. Tiroid bezinden aşırı tiroid hormonu üretimi ile karakterize olan hipertiroidizmin bilişsel işlevlerde değişikliklere neden olduğu bilinmektedir. Bu çalışmada, işitsel uyaranlara reaksiyon zamanı ölçülerek hipertiroidi’nin bilişsel süreçten kaynaklanan motor yanıt üzerine etkisi araştırıldı.Materyal ve Metot: Çalışma, yeni tanı konmuş hipertiroidi hastaları (n=20) ve sağlıklı kontrol grubu (n=20) üzerinde yürütüldü. Tepki süresi işitsel oddball paradigması ile değerledirildi. Bu amaçla katılımcılara 160 ses uyaranı verildi (120 standart, 40 hedef). Katılımcılara ses uyaranını duyduklarında sağ ellerinin altındaki butona basmaları istendi. Uyaranın verilmesi ve butona basma süresi arasında geçen süre reaksiyon zamanı olarak hesaplandı. Bulgular: Reaksiyon zamanı anlamlı şekilde hipertiroidi grubunda kontrol grubuna göre uzadı (p≤0,001). Sonuç: Hipertiroidili hastalarının algılama süreleri uzamakta, dikkat ve konsantrasyonda anlamlı azalma olmuştur. Bu duruma bozulmuş motor fonksiyondan kaynaklanan uzamış reaksiyon zamanı neden olmuş olabilir.

Anahtar Kelimeler:

reaksiyon zamanı, Oddball paradigması, hipertiroidi, insan; biliş

Research of the Effect of Hyperthyroidism on Reaction Time Using the Oddball Paradigm

Aim: Thyroid hormones are so important for the normal physiological functions and the cognitive functions of brain. It is known that hyperthyroidism, the presence of excessive thyroid hormone produced by the thyroid gland, causes changes in cognitive functions. In this study, we have examined the effect of hyperthyroidism on motor response that result from this cognitive process by measuring reaction time to auditory stimuli. Material and Method: The study was conducted on newly diagnosed hyperthyroid patients (n=20) and healthy controls (n=20). The reaction time was evaluated in an auditory oddball paradigm. For that purpose, participants have been listened to 160 sound stimuli (120 standards, 40 targets). We asked them to press the button under their right hand when they hear the target sounds. The elapsed time between the presentation of the stimulus and the subsequent pressing button has been defined as reaction time. Results: Reaction time was significantly prolonged in the hyperthyroid group compared with the control group (p≤0.001). Conclusion: Hyperthyroid patients had prolonged perception time and significant decrease on attention and concentration. They can be result in prolonged reaction time because of impaired motor functions.

Keywords:

hyperthyroidism, Oddball paradigm, reaction time,

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