İbrahim YAĞCI, Yasin TAŞDELEN, Yüksel KIVRAK

Venlafaksin Tedavisine Sülpirid Eklenmesi Sonrası Görülen Hiperprolaktinemi: Olgu Sunumu

Hiperprolaktinemi, hipotalamo-hipofizyal eksenin en çok karşılaşılan endokrin bozukluğudur. En sık nedenleri hipofiz adenomları, kronik böbrek yetersizliği ve antipsikotik ilaç kullanımıdır. Prolaktinin normal düzeyi 20–25 ng/ml altındadır. Antipsikotik ilaçlar hiperprolaktinemiye ön hipofizdeki D2 dopamin reseptörlerini bloke ederek neden olurlar. Antipsikotiklerin neden olduğu hiperprolaktineminin en sık belirtileri; galaktore, menstrüel döngü düzensizlikleri, amenore, libidoda azalma, göğüste duyarlılık, kemik mineral dansitesinde azalmadır. Bu nedenle de galaktoreyi erken fark etmek önemlidir. Bilebildiğimiz kadarı ile literatürde sülpiridin çok düşük dozda (50 mg/gün) kullanımı sonrası görülen hiperprolaktinemiye bağlı galaktore olgusu bulunmamaktadır. Bu yazıda depresyon tanısı ile venlafaksin 150 mg/gün kullanan hastanın tedavisine sülpirid 50 mg/gün eklenilmesi sonucu hiperprolaktinemiye bağlı galaktore görülen bir olgu sunulmuştur.

Anahtar Kelimeler:

sülpirid, hiperprolaktinemi, antipsikotik ilaçlar; depresyon

Hyperprolactinemia Due to the Sulpiride Addition to Venlafaxine Treatment: A Case Report

Hyperprolactinemia, is the most common hypothalamo-hypopysial endocrine disorder. The most common etiologies are; hypophysis adenoma, chronic kidney failure and antiphyschotic drug use. Normal range of prolactin blood level is below 20–25 ng/ml. Antipsychotic drugs cause hyperprolactinemia by blocking the D2 dopamine receptors in the frontal lobe of the hypophysis. The most common symptoms of hyperprolactinemia due to antipsychotic drug use are: galactorrhea, menstrual cycle dysregulation, amenorrhea, decrease in libido, breast sensitivity, decrease in the bone mineral density. Therefore, it is important to diagnose galactorrhea as early as possible. As far as we know there is no reported cases of hyperprolactinemia induced galactorrhea due to very low dose (50 mg/day) sulpiride use. In this study, we report a case of galactorrhea due to hyperprolactinemia as a result of sulpiride 50 mg/daily drug addition to the venflaxine 150 mg/daily treatment in a depressive patient.

Keywords:

sulpiride, hyperprolactinemia, antipsychotic drugs; depression,

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