Topiramate add-on for treatment of migraine-type headache cures alcohol dependence: a case report
Topiramate add-on for treatment of migraine-type headache cures alcohol dependence: a case report
Topiramate presents a broad-spectrum efficacy in the treatment of different psychiatric and neurological conditions, assuggested by findings from studies on addiction, epilepsy, and migraine headaches. Here, we present a patient with adiagnosis of alcohol dependence that was treated with topiramate for migraine headaches as an add-on treatment topsychiatric medications. Alcohol craving and consumption were significantly reduced. Additionally, the patient’s migrainesymptoms improved, without the appearance of side effects.
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- 1. Arbaizar B, Gomez-Acebo I, Llorca J. Efficacy of topiramate in bulimia nervosa and binge-eating disorder: a systematic review. Gen Hosp Psychiatry. 2008;30(5):471-5. [CrossRef]
- 2. Johnson BA, Ait-Daoud N, Akhtar FZ, Javors MA. Use of oral topiramate to promote smoking abstinence among alcoholdependent smokers: a randomized controlled trial. Arch Intern Med. 2005;165(14):1600-5. [CrossRef]
- 3. Jonhson BA, Rosenthal N, Capece JA, Wiegand F, Mao L, Beyers K, et al. Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA. 2007;298(14):1641-51. [CrossRef]
- 4. Arbaizar B, Dierssen-Sotos T, Gomez-Acebo I, Llorca J. Topiramate in the treatment of alcohol dependence: a meta-analysis. Actas Esp Psiquiatr. 2010;38(1):8-12.
- 5. Angehagen M, Ronnback L, Hansson E, Ben-Menachem E. Topiramate reduces AMPA-induced Ca(2+) transients and inhibits Glu R1 subunit phosphorylation in astrocytes from primary cultures. J Neurochem. 2005;94(4):1124-30. [CrossRef]
- 6. White HS, Brown SD, Woodhead JH, Skeen GA, Wolf HH. Topiramate modulates GABA evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism. Epilepsia. 2000;41(Suppl.1):17-20. [CrossRef]
- 7. Weiss F, Porrino LJ. Behavioral neurobiology of alcohol addiction: recent advances and challenges. J Neurosci. 2002;22(9):3332-7.
- 8. Johnson BA, Ait-Daoud N, Akhtar FM, Ma JZ. Oral topiramate reduces the consequences of drinking and improves the quality of life of alcohol-dependent individuals: a randomized controlled trial. Arch Gen Psychiatry 2004;61(9):905-12. [CrossRef]
- 9. De Sousa AA, De Sousa, JA, Kapoor H. An open randomized trial comparing disulfiram and topiramate in the treatment of alcohol dependence. J Subst Abuse Treat. 2008;34(4):460-3. [CrossRef]