Ozlem YAGİZ AGHAYAROV, Aydın KESKİNRÜZGAR, Ayşe Sevgi KARADAĞ, Aynur ALİYEVA, Demet IŞIK BAYRAKTAR, İbrahim ÇUKUROVA

İnaktif Behçet Hastalığı'nda İnflamatuar Belirteçler

Amaç: Behçet hastalığı kronik multisistem tulumlu inflamatuar bir hastalıktır ve hastalık aktivitesinin tanı ve takibinde birçok sitokin ve biyobelirteç tanımlanmıştır. Nötrofil-lenfosit oranı (NLR) ve trombosit-lenfosit oranı (PLR), otoimmün hastalıklarda hastalık şiddetini değerlendirmek için yeni inflamatuar biyobelirteçler olarak kullanılmaktadır. Çalışmanın amacı, inaktif dönemdeki Behçet hastalarında NLR ve PLR değerlerini incelemektir. Gereç ve Yöntemler: Dahiliye kliniği tarafından detaylı sistemik muayenesi yapılan, çalışmaya dahil edilme kriterlerine uyan ve hastalık aktivitesi değerlendirildikten sonra inaktif olarak kabul edilen hastalar çalışmada yer alan diğer kliniklerce (kulak burun boğaz hastalıkları, göz hastalıkları ve diş hekimliği) olası inflamatur ve malign hastalıklar yönünden değerlendirildi. NLR yüksekliği yapabilecek diğer nedenler ekarte edildikten sonra 40 Behçet hastası ve 45 sağlıklı kontrol çalışmaya dahil edildi. Bu iki grubun NLR ve PLR değerleri karşılaştırıldı. Bulgular: Hasta grubunun NLR değerleri kontrol grubuna oranla istatistiksel olarak daha yüksekti. Hasta grubunda PLR değerleri daha yüksekti ancak istatistiksel olarak anlamlı fark yoktu. Sonuç: Çalışmadaki hastalarda NLR yüksekliğine neden olabilecek diğer durumlar tüm branşlar tarafından değerlendirildikten sonra ve hastalar inaktif evrede oldukları halde NLR yüksek bulunmuştur. Bu durum Behçet hastalığında hastada klinik bulgu olmasa ve hasta inaktif evrede olsa dahi altta yatan bir inflamatuar durumu desteklemektedir.

Anahtar Kelimeler:

Behçet hastalğı, Nötrofil-lenfosit oranı, Trombosit-lenfosit oranı;, Hastalık aktivitesi, Trombosit-lenfosit oranı

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