Oya KELEŞ, Tülay BAKIREL, Süleyman ŞENER, Emine BAYDAN, Gürdal DAĞOĞLU

The effect of danofloxacin on pharmacokinetic properties of antipyrine in a therapeutic period dependend manner

Florokinolon grubuna ait bir bileşik olan danofloksasinin, karaciğer mikrozornal ilaç metabolizma fonksiyonunu değiştirme özelliği incelendi. Bu amaçla tavuklara oral yolla 5 mg/kg/canh ağırlık dozda, günde bir kez olmak üzere 3 ve 6 gün süresince danofloksasin uygulamasının antipirin (20 mg/kg) kinetiği üzerine etkisi incelendi. Üç gün süresince danofloksasin uygulandıktan sonra elde edilen antipirinin plazma yoğunluğu - zaman eğrisinde eğri altındaki alanı, ortalama kalış süresi ve eliminasyon yan ömrü gibi farmakokinetik değerler, danofloksasin öncesi ve kontrol grubu değerlerinden belirgin olarak daha yüksek, a değeri ise düşük bulundu. Aynı dozda 6 gün süresince danofloksasin verilmesi ise antipirinin yan ömründe herhangi değişikliğe neden olmaksızın eğri altındaki alanı ve organizmadaki kalış süresini daha da artırdı. Bu sonuçlar danofloksasinin oksidatif metabolizmayı inhibe edebildiğini gösterir.

Sağaltım süresine bağlı olarak antipirinin farmakokinetiği üzerine danofloksasisinin etkisi

A fluroquinolone, danofloxacin, was evaluated for its ability to alter hepatic microsomal drug-metabolising function. The influence of treatment with danofloxacin at a dose rate of 5 mg kg body weight"1 orally once a day for 3 and 6 consecutive days on pharmacokinetic of antipyrine (20 mg/kg) was investigated in chickens. After danofloxacin treatment for 3 consecutive days, the area under the curve, mean residence time and the elimination half-life of antipyrine were significantly higher than in the chicken before danofloxacin treatment and in control group whereas alpha decreased significantly. The administration of danofloxacin at the same dose for 6 days increased the area under the curve and mean residence time of antipyrine without any changes in half-life as compared with danofloxacin treatment for 3 days. The results suggest that the danofloxacin is capable of inhibiting oxidative metabolism.

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