İvermektin ve amitraz ile sağaltılan demodicosisli köpeklerde hematolojik ve biyokimyasal bulgular

Bu çalışmada Dernodex canis ile enfekte 20 köpek kullanıldı. Köpeklerde lezyorpar vücudun her tarafında görüldü. Tüm köpeklerde şiddetli kaşıntı, kıl dökülmesi, iştahsızlık, kepeklenme ve kaşeksi gözlendi. Bütün köpeklerden alınan deri kazıntısında Demodex etkenlerinin tüm gelişme dönemleri gözlendi. Tüm köpeklerden sağaltımdan önce ve 3 hafta sonra kan alındı. Kanda, eritrosit, lökosit ve trombosit sayılan hemoglobin miktarı, hematokrit değeri, MCV, MCH, MCHC, RDW, MPV, glikoz, aspartate aminotransferase (AST), alanine aminotransferase (ALT), kreatinin, total bilirubin, albumin ve üre değerleri saptandı. Sağaltım öncesi ve 3 hafta sonraki köpeklerin ortalama kan değerleri arasındaki fark eritrosit ve lökosit sayıları, hematokrit değer ve MPV için (p

Hematological and biochemical findings in demodicosis dogs treated with ivermectin and amitraz

In this study, twenty dogs naturally infected with Demodex canis were examined. The lesions were seen in the whole surface of the bodies of the dogs. In all dogs, intense itching, loss of hair, anorexia, scurfs and cachexia were observed. The Demodex agents in all stages of development were observed in the scrapings taken from the dogs. Blood samples were taken from all dogs before and after 3 weeks the treatment. From these blood samples erythrocyte, leucocyte and thrombocyte counts, hemoglobin amount, haematocrit value, mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), red blood cell distribution width (RDW), mean platelet volume (MPV), serum glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, total bilirubin, albumin and urea values were determined. The differences between the mean values of dogs before and after 3 weeks the treatment were significant for erythrocyte and leucocyte counts, haematochrit value and (MPV) (p

PDF

___

1) Bagley, R. S., Center, S. A., Lewis, R.M., Shin, S., Dougherty, S.A., Randolph, J.F., Erb, H. (1991): The effect of experimental cystitis and iatrogenic blood contamination on the urine protein, creatinine ratio in the dog. J. Vet. İnternal Med., 5(2): 66-70. 2) Cook., S.M., Dean, D.F., Golden, D.L., Wilkinson, J.E., Means, T.L. (1993): Renal failure attributable to atrophic glomerulopathy in four related Rottweillers. J. Am. Vet. Med. Ass. 202 (1):107-109. 3) Coskun, S.Z. (1983): Avermektinlerle yapılan yeni deneyler ve alınan sonuçlar. A. Ü. Vet. Fak. Derg. 30(4):562-570. 4) Cuccherini, B., Nussbaum, S.J., Seef, L.B., Lucacs, L., Zimmerman, H.J. (1983): Stability of aspartate aminotransferase and alanine aminotransferase activities. J Lab Clin Med 1983 Sep 102:3 370-376. 5) Demmler, M., Kaspar, H.M., Möhring, C., Klauss, V. (1997): Blepharitis, Demodex folliculorum, associated pathogen spectrum and specific therapy. Ophthalmologie. 94(3):191- 196. 6) Duclos, D.D., Jeffers, J.G., Shanley, K.J.(1994): Prognosis for treatment of adult-onset demodicosis in dogs. J. Am. Vet. Med. Assoc. 204(4):616-619. 7) Euzeby, J. (1975): Dermatoses parasitaires du chien. Revue Med. Vet., 126(1): 79-105. 8) Folz ,S.D., Kratzer, D.D., Conklin, R.D., Nowakowski, L.H., Kakuk, T.J., Rector, R.D.(1983): Chemotherapeutic treatment of naturally acquired generalized demodicosis. Vet. Parasitol. 13(1): 85-93. 9) Folz, S.D., Kakuk, T.J., Henke, C.L., Rector, D.L., Tesar, F.B.(1984): Clinical evaluation of amitraz for treatment of canine scabies. Mod. Vet. Pract. 65(8):597-600. 10) Folz, S.D., Kratzer, D.D., Kakuk, T.J., Rector, D.L.(1984): Evaluation of a sponge-on therapy for canine scabies. J. Vet. Pharmacol. Ther. 7(1):29-34. 11) Grant, D.İ. (1985): Notes on parasitic skin disease in the dog and cat. Br. Vet. J. 141-147. 12) Henfrey, J.I (1990): Canine demodicosis. In Practice. 187-192. 13) Konrád, J., Cupák, M., Husák, S.(1980): [Selected biochemical values of clinically healthy dogs]. Vet Med (Praha) 25(7) 413-422.
14) Kristensen, A.T., Feldman, B.F.(1995): General principles of small animal blood component administration. Vet Clin North Am Small Anim Pract 25(6) 1277-1290. 15) Meeus, P.F.M., De Bont, J., Vercruysse, J. (1997): Comparison of the persistent activity of ivermectin, abamectin, doramectin and moxidectin in cattle in Zambia. Vet. Parasitol. 70:219- 224. 16) Mısra, M.S., Mısra, S.K., Mısra, A., Mısra, P.K. (1974): Calcium, phosphorus and Vitamin-A content of the serum of normal dermatitic dogs. İndian Journal of Animal Health. 13(2): 153-154. 17) Mimioglu, M.M., Sahin, I., Alp, U.(1979): Demodectic in adog in Beytepe University Campus (Autors transl.). Mikrobiyol Bul. 13(4):401-405. 18) Person, J.M., Rieux, M.E., Quintin, C.F., De-Rieux, M.C. (1989): L’ infection urinaire ehez le chien et le chat. Analyse des resultants de 459 urocultures realises entre 1977 et 1981 a I’Ecole Nationale Veterinaire d’Alford. Recueil de Medecine Vet., 165(1):45-53. 19) Robin, B.(1983): İvermectine: 22,23 dihydro-avermectine B1: un nouvel antiparasitaire A tre’s large spektre. Revue Med. Vet. 134:495-498. 20) Schalm, O.W., Jain, N.C., Carroll, E.J. (1975): Veterinary Hematology. 3. Edition. Lea and Febiger. Philadelphia. 87-89.655-701. 21) Skibba, J.L., Almagro, U.A., Condon, R.E., Petroff, J.R.(1983): A technique for isolation perfusion of the canine liver with survival. J Surg Res 34(2) 123-132. 22) Skogerboe, T.L., Cracknell, V.C., Walstrom, D.J., Ritzhdupt, L., Karle, V.K. (1999):The effect of simulated rainfall on the efficiancy of doramectin pour-on againist nematode of cattle. Vet. Parasitol. 86:229-234. 23) Snedecor, G.W., Cochron, W. (1976): Statistical Methods. The Iowa State Universty Press Ames. U.S.A. 32-193. 24) Speeti, M., Ihantola, M., Westermarck, E. (1996): Subclinical versus clinical hepatitis in the dobermann: evaluation of changes in blood parameters. J Small Anim Pract 37:(10) 465-470. 25) Uysal, A. (1984): Normal ve anemili köpeklerin erythrocyte, leucocyte sayısı ve hemoglobin miktarı ve mikrohematokrit degerler arasında karsılastırmalı arastırmalar. (Doktora Tezi). İstanbul Univ. Vet. Fak. Derg. 10(2):83-95. 26) Uysal, A., Bilal, T. (1990): Saglıklı Sivas Kangal köpeklerinde bazı kan parametreleri üzerine çalısmalar. İstanbul Üniv. Vet. Fak. Derg. 16(2): 27-34. 27) Uysal, A., Mahzunlar, H. (1989): Saglıklı köpeklerde ivermektinin karaciger ve bazı kan parametreleri üzerine etkisi. İstanbul Üniv. Vet. Fak. Derg. 15(2):21-27.
28) Uysal, A., Or, E., Bilal, T. (1992): Demodex canis ile enfekte köpeklerde ivermectin ile tedavi çalısmaları. İstanbul Üniv. Vet. Fak. Derg. 18(2):29-32. 29) Valentine, B.A., Blue, J.T., Shelley, S.M. Cooper, B.J. (1990):Increased serum alanine aminotransferase activity associated with muscle necrosis in the dog. J Vet Intern Med 4:(3) 140- 143. 30) Wicks, S.R., Kaye, B., Weatherley, A.J., Lewis, D., Davison, E., Gibson, S.P., Smith, D.G.(1993): Effect of formulation on the pharmacokinetics and efficacy of doramectin. Vet. Parasitol. 49:17-26.