Kanser Tedavisine Bağlı Gelişen Oral Mukozit Yönetiminde Kanıt TemelliTamamlayıcı Tedaviler

Kanser tedavisine bağlı gelişen oral mukozit; ağrı, beslenmede yetersizlik, kilo kaybı ve tedavinin ertelenmesi gibi birçok soruna yol açan ve hastaların yaşam kalitesini olumsuz yönde etkileyen önemli bir sorundur. Mevcut ağız bakımı yaklaşımlarına rağmen bu sorun güncelliğini korumakta ve yeni yöntemlerin etkinliği araştırılmaktadır. Etkinliği araştırılan uygulamalar arasında tamamlayıcı tedaviler, sağlık profesyonellerinin oral mukozit yönetimine ilişkin kanıt oluşturmak amacıyla sıklıkla araştırma yaptığı alanlardan biri haline gelmiştir. Kriyoterapi, düşük yoğunluklu lazer tedavisi, bitkisel yaklaşımlar ve besin destekleri, apiterapi, esansiyel yağlar ve bilişsel davranışçı yaklaşımlar oral mukozit yönetiminde etkinliği araştırılan tamamlayıcı tedavi yaklaşımları arasında yer almaktadır. Bu derlemede kanser tedavisine bağlı gelişen oral mukozit yönetiminde etkinliği araştırılmış tamamlayıcı tedavi yaklaşımlarına ilişkin araştırma örnekleri sunulmuş ve bu yöntemlerle ilgili kanıta dayalı uygulama rehberlerinde yer alan önerilere yer verilmiştir.

Complementary Therapies in the Management of Induced Oral Mucositis during Cancer Treatment

Oral mucositis is an important problem that may cause pain, weight loss, and the delay of treatment, which can lead to a low quality of life in patients undergoing cancer treatment. Despite available mouth care approaches, the problem remains unsolved. The effects of new methods have been investigated and among these, complementary therapies have become one of the areas where health professionals conduct research to generate evidence for the management of oral mucositis. Cryotherapy, low level laser treatment, herbal methods and nutritional supplements, apitherapy, essential oils, and cognitive behavioral techniques are among these complementary therapies. This review presents examples of research studies investigating the effects of complementary therapies on oral mucositis management and includes recommendations with evidence-based practice guidelines for these methods.

___

  • 1 . Fall-Dickson JM, Berger AM. Oral complications. Managements of adverse effects of treatment. In: DeVita VT, Lawrence ST, Rosenberg SA, eds. Cancer Principles & Practice of Oncology. 8th ed. USA: Lippincott Williams & Wilkins; 2008: 2655-2668.
  • 2 . Rubenstein EB, Peterson DE, Schubert M, Keefe D, McGuire D, Epstein J et al. Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer, 2004; 100(Suppl. 9):2026-2046. doi:10.1002/cncr.20163
  • 3 . Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol. 1999; 17(8):2412-2418. doi: 10.1200/ JCO.1999.17.8.2412
  • 4 . Köstler WJ, Hejna M, Wenzel C, Zielinski CC. Oral mucositis complicating chemotherapy and/or radiotherapy: Options for prevention and treatment. CA Cancer J Clin. 2001; 51(5):290-315. doi: 10.3322/canjclin.51.5.290
  • 5 . Ebstein JB, Schubert MM. Managing pain in mucositis. Semin Oncol. 2004; 20(1):30-37
  • 6 . Clarkson JE, Worthington HV, Furness S, McCabe M, Khalid T, Meyer S. Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev. 2010; 8:1-80. doi: 10.1002/14651858.CD001973.pub4
  • 7 . Mengxue He. Interventions for preventing oral mucositis in patients with cancer receiving treatment. Clin Nurse Spec. 2011; 25(6):284-85. doi: 10.1097/NUR.0b013e318233e951
  • 8 . Can, G. (2007). Gastrointestinal sorunlar. İçinde: Onkoloji Hemşireliğinde Kanıta Dayalı Semptom Yönetimi. İstanbul: 3P-Pharma Publication Planning; 2007: 81-101
  • 9 . Panahi Y, Ala S, Safedi M, Okhovatian A, Bazzaz N, Naghizadeh MM. Allopurinol mouth rinse for prophylaxis of fluorouracil-induced mucositis. Eur J Cancer Care. 2010; 19(3):308-312. doi:10.1111/j.1365-2354.2008.01042.x
  • 10 . Çubukçu NÜ, Çınar S. Kemoterapi alan kanserli hastalarda oral mukozitler önlenebilir mi? Marmara Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 2012; 2(4):155-163. http://e-dergi.marmara.edu.tr/ marusbed/article/view/5000003676
  • 11 . Katrancı N. Ovayolu N. Ovayolu Ö, Sevinç A. Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy-a randomized controlled trial. Eur J Oncol Nurs. 2012; 16(4):339-44. doi: 10.1016/j.ejon.2011.07.008
  • 12 . Arbabi-Kalati F, Arbabi-Kalati F, Moridi T. Evaluation of the effect of low level laser on prevention of chemotherapy-induced mucositis. Acta Med Iran. 2013; 51(3):157-162. http://acta.tums.ac.ir/index.php/acta/ article/view/4471
  • 13 . Topuz E, Derin D, Can G, et al. Effect of oral administration of kefi r on serum proinfl ammatory cytokines on 5-FU induced oral mucositis in patients with colorectal cancer. Invest New Drugs. 2008; 26 (6):567- 572. doi:10.1007/s10637-008-9171-y
  • 14 . Fidler P, Loprinzi CL, O'Fallon JR, et al. Prospective evaluation of chamomile mouthwash for prevention of 5-FU-induced oral mucositis. Cancer. 1996; 77:522-525. doi: 10.1002/(SICI)1097- 0142(19960201)77:3_____522::AID-CNCR14>3.0.CO;2-6
  • 15 . Su CK, Mehta V, Ravikumar L, et al. Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation related mucositis in patients head and neck neoplasms. Int. J. Radiation Oncology Biol Phys. 2004; 60(1):171-177. doi:10.1016/j. ijrobp.2004.02.012
  • 16 . Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, et al. Antioxidant capacity of Calendula offi cinalis fl owers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. Daru. 2013; 21(1):18. doi:10.1186/2008-2231-21-18
  • 17 . Demir M, Can G, Meral R. The effectiveness of the black mulberry molasses in prevention of radiotherapy-induced mucositis: a randomised controlled study in head and neck cancer patients. Eur J Oncol Nurs. 2014; 18(Suppl.1):S1-S22. doi:10.1016/S1462-3889(14)70036-5
  • 18 . Elkerm Y, Tawashi R. Date palm pollen as a preventative intervention in radiation and chemotherapy-induced oral mucositis: a pilot study. I nt e g r C a n c e r T h e r. 2 0 1 4; 1 3 ( 6 ): 4 6 8 - 7 2. d oi: 10.1177/1534735414547110
  • 19 . El-Housseiny A, Saleh S, El-Masry A, Allam A. The effectiveness of vitamin "E" in the treatment of oral mucositis in children receiving chemotherapy. J Clin Pediatr Dent 2007; 31(3):167-170. https://www. ncbi.nlm.nih.gov/pubmed/?term=The+ effectiveness+of+vitamin+%22 E%22+in+the+treatment+of+oral+mucositis+in+children+receiving+ch emotherapy
  • 20 . Maiti PK, Ray A, Mitra TN, Jana U, Bhattacharya J, Ganguly S. The effect of honey on mucositis induced by chemoradiation in head and neck cancer. J Indian Med Assoc. 2012; 110 (7):453-456. https://www.ncbi. nlm.nih.gov/pubmed/23520669
  • 21 . Bensadoun RJ, Nair RG. Low-level laser therapy in the prevention and treatment of cancer therapy-induced mucositis: 2012 state of the art based on literature review and meta-analysis. Curr Opin Oncol. 2012, 24:363-370. doi: 10.1097/CCO.0b013e328352e aa3
  • 22 . Ashktorab T, Yazdani Z, Mojab F, Majd H, Madani H. Preventive effects of an oral rinse peppermint essence on chemotherapy-induced oral mucosistis. Journal of Semnan University of Medical Sciences. 2010; 12(1):8-13. http://koomeshjournal.semums.ac.ir/ browse.php?a_ id=953&sid=1&slc_lang=en
  • 23 . Papadeas E, Naxakis S, Riga M, Kalofonos Ch. Prevention of 5-fl uorouracil-related stomatitis by oral cryotherapy: A randomized controlled study. Eur J Oncol Nurs. 2007; 11:60-65. doi./10.1016/j. ejon.2006.05.002
  • 24 . Sorensen JB, Skovsgaard T, Bork E, Damstrup L, Ingeberg S. Doubleblind, placebo-controlled, randomized study of chlorhexidine prophylaxis for 5-Fluorouracil-based chemotherapy-induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies. Cancer. 2008; 112(7):1600-1606. doi: 10.1002/cncr.23328
  • 25 . Nikoletti S, Hyde S, Shaw T, Myers H, Kristjanson LJ. Comparison of plain ice and fl avoured ice for preventing oral mucositis associated with the use of 5 fl uorouracil. J Clin Nurs 2005; 14(6):750-753. doi: 10.1111/j.1365-2702.2005.01156.x
  • 26 . Svanberg A, Öhrn K, Birgegard K. Oral cryotherapy reduces mucositis and improves nutrition-a randomised controlled trial. J Clin Nurs. 2010; 19:2146-2151. doi: 10.1111/j.1365-2702.2010.03255.x
  • 27 . Lalla RV, Bowen J, Barasch A, et al. The mucositis guidelines leadership group of the multinational association of supportive care in cancer and international society of oral oncology (MASCC=ISOO). 2014; Cancer. 120(10):1453-1461. doi: 10.1002/cncr.28592
  • 28 . Silva GB, Sacono NT, Othon-Leite AF, Mendonça EF, Arantes AM, Bariani C et al. Effect of low-level laser therapy on infl ammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study. Lasers Med Sci. 2015; 30(1):117-126. doi: 10.1007/s10103-014-1624-2
  • 29 . Çıtlak K, Kapucu S. Kemoterapi alan hastalarda görülen oral mukozitin önlemesi ve tedavisinde güncel yaklaşımlar: Kanıta dayalı uygulamalar. Hacettepe Üniversitesi Hemşirelik Fakültesi Dergisi. 2015; 2(1):70-77. http://dergipark.ulakbim.gov.tr/ hunhemsire/article/ view/5000154797/5000140005
  • 30 . Khouri VY, Stracieri AB, Rodrigues MC, et al. Use of therapeutic laser for prevention and treatment of oral mucositis. Braz Dent J. 2009; 20(3):215-220. doi: 10.1590/S0103-64402009000300008
  • 31 . Nes AG, Posso MBS. Patients with moderate chemotherapy-induced mucositis: pain therapy using low intensity lasers. Int Nurs Rev. 2005; 52:68-72. doi: 10.1111/j.1466-7657.2004.00401.x
  • 32 . Ferreira B, da Motta Silveira FM, de Orange FA. Low-level laser therapy prevents severe oral mucositis in patients submitted to hematopoietic stem cell transplantation: a randomized clinical trial. Support Care Cancer. 2016; 24(3):1035-1042 doi: 10.1007/s00520-015-2881-8
  • 33 . Aghamohamamdi A, Hosseinimehr SJ. Natural products for management of oral mucositis induced by radiotherapy and chemotherapy. Integr Cancer Ther. 2016; 15(1):60-68. doi: 10.1177/1534735415596570
  • 34 . Carl W, Emrich LS. Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients. J Prosthet Dent 1991; 66(3):361-369. doi: 10.1016/0022-3913(91)90264-W
  • 35 . Pavesi VC, Lopez TC, Martins MA, Sant'Ana Filho M, Bussadori SK, et al. Healing action of topical chamomile on 5-fl uoracil induced oral mucositis in hamster. Support Care Cancer. 2011; 19(5):639-646. doi: 10.1007/s00520-010-0875-0
  • 36 . Sahu PK, Giri DD, Singh R, Pandey P, Gupta S, Shrivastava AK, et al. Therapeutic and medicinal uses of Aloe vera: A review Pharmacology & Pharmacy. 2013; 4:599-610. doi: 10.4236/pp.2013.48086
  • 37 . Yarom N, Ariyawardana A, Hovan A, et al. Systematic review of natural agents for the management of oral mucositis in cancer patients. Support Care Cancer. 2013; 21:3209-3221. doi: 10.1007/s00520-013-1869-5
  • 38 . Puataweepong P, Dhanachai M, Dangprasert S, et al. The effi cacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: a double-blind placebo-controlled study. Asian Biomedicine. 2009; 3(4):375-382. https://www.researchgate.net/ publication/267721093_The_ effi cacy_of_ oral_Aloe_vera_juice_for_ radiation_induced_mucositis_in_head_and_neck_cancer_patients_A_ double-blind_placebo-controlled_study
  • 39 . Tanideh N, Tavakoli P, Saghiri MA, et al. Healing acceleration in hamsters of oral mucositis induced by 5-fl uorouracil with topical Calendula offi cinalis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115(3):332-338. doi: 10.1016/j.oooo.2012.08.450
  • 40 . Salvo N, Barnes E, van Draanen J, et al. Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature. Curr Oncol. 2010; 17:94-112.44. https://www.ncbi.nlm.nih. gov/pmc/articles/PMC2913836/pdf/conc-17-4-94.pdf
  • 41 . Chandran PK, Kuttan R. Effect of Calendula offi cinalis fl ower extract on acute phase proteins, antioxidant defense mechanism and granuloma formation during thermal burns. J Clin Biochem Nutr. 2008; 43(2):58- 64. doi: 10.3164/jcbn.2008043
  • 42 . Akkol EK, Süntar I, Keleş H, Sezik E, Gürler G. Bioassay-guided isolation and characterization of wound healer compounds from Morus nigra L. (Moraceae). Rec. Nat. Prod. 2015; 9(4):484-495. http://www. acgpubs.org/RNP/2015/Volume9/Issue% 201/59-RNP-1308-391.pdf
  • 43 . Yiğit N, Yiğit D, Özgen U, Aktaş AE. Karadut (Morus nigra L.)'un antikandidal aktivitesi. Türk Mikrobiyol Cem Derg. 2007; 37(3):169- 173. http://tmc.dergisi.org/pdf/pdf_TMC_293.pdf
  • 44 . Tomas M, Toydemir G, Boyacıoğlu D, Hall R, Beekwilder J, Capanoglu E. The effects of juice processing on black mulberry antioxidants. Food Chem. 2015; 186:277-284. doi: 10.1016/j.foodchem.2014.11.151
  • 45 . Rodrigues KL. Gaudino Capito LR, Tavares Carvalho JC, Evangelista J, Schneedorf JM. Antimicrobial and healing activity of kefi r and kefi ran extract. Int J Antimicrob Agents. 2005; 25:404-408. doi: 10.1016/j. ijantimicag.2004.09.020
  • 46 . Vinderola G, Perdigon G, Duarte J, Farnworth E, Matar C. Effects of the oral administration of the products derived from milk fermentation by kefi r microfl ora on immune stimulation. Journal of Dairy Research. 2006; 73(4):472-479. doi: 73:472-479. 10.1017/S002202990600197X
  • 47 . Wadleigh RG, Redman RS, Graham ML, Krasnow SH, Anderson A, Cohen MH. Vitamin E in the treatment of chemotherapy-induced mucositis. Am J Med. 1992; 92(5):481-484. doi: 10.1016/0002- 9343(92)90744-V
  • 48 . High KP, Legault C, Sinclair JA, Cruz J, Hill K, Hurd DD. Low plasma concentrations of retinol and alpha-tocopherol in hematopoietic stem cell transplant recipients: the effect of mucositis and the risk of infection. Am J Clin Nutr. 2002; 76(6):1358-1366. http://ajcn.nutrition.org/ content/76/6/1358.full.pdf+html
  • 49 . Ferreira PR, Fleck JR, Diehl A, Barletta D, Braga-Filho A, Barletta A et al. Protective effect of alpha-tocopherol in head and neck cancer radiation-induced mucositis: a double-blind randomized trial. Head Neck. 2004; 26(4):313-321. doi: 10.1002/hed.10382
  • 50 . Sung L, Tomlinson GA, Greenberg ML, Koren G, Judd P, Ota S. Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients. Eur J Cancer. 2007; 43(8):1269-1275. doi: 10.1016/j.ejca.2007. 02.001
  • 51 . Cuba LF, Salum F, Cherubini, K, Zancanaro de Figueiredo MA. Antioxidant agents: A future alternative approach in the prevention and treatment of radiation-induced oral mucositis? Altern Thr Health Med. 2 0 1 5; 2 1 ( 2 ): 3 6 - 4 1. htt p s:// w w w. R e s e a r c h g at e. n et/ publication/274401334_Antioxidant_Agents_A_Future_Alternative_ Approach_in_the_Prevention_and_Treatment_of_Radiation-induced_ Oral_Mucositis
  • 52 . Manzi Nde M, Silveira RC, Reis PE. Prophylaxis for mucositis induced by ambulatory chemotherapy: systematic review. J Adv Nurs. 2016; 72(4):735-746. doi: 10.1111/jan.12867
  • 53 . Schelz Z, Molnar J, Hohmann J. Antimicrobial and antiplasmid activities of essential oils. Fitoterapia. 2006; 77(4):279-285. doi: 10.1016/j. fi tote.2006.03.013
  • 54 . Gravett P. Aromatherapy treatment of severe oral mucositis. Int J Aromather. 2000; 10:52-53. doi: 10.1016/S0962-4562(00)80009-0
  • 55 . Maddocks-Jennings W, Wilkinson JM, Cavanagh HM, Shillington D. Evaluating the effects of the essential oils Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) on radiotherapy induced mucositis: A randomized, placebo controlled feasibility study. Eur J Oncol Nurs. 2009; 13(2):87-93. doi: 10.1016/j.ejon.2009.01.002
  • 56 . Bardy J, Molassiotis A, Ryder WD, Mais K, Sykes A, Yap B, et al. A double-blind, placebo-controlled, randomised trial of active manuka honey and standard oral care for radiation-induced oral mucositis. Br J Oral Maxillofac Surg. 2012; 50(3):221-226. doi: 10.1016/j. bjoms.2011.03.005
  • 57 . Song JJ, Twumasi-Ankrah P, Salcido R. Systematic review and metaanalysis on the use of honey to protect from the effects of radiationinduced oral mucositis. Adv Skin Wound Care. 2012; 25:23-28. doi: 10.1097/01.ASW.0000410687.14363.a3
  • 58 . Khanal B, Baliga M, Uppal N. Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. Int J Oral Maxillofac Surg. 2010; 39(12):1181-1185. doi: 10.1016/j. ijom.2010.05.014
  • 59 . Raeessi MA, Raeessi N, Panahi Y, Gharaie H, Davoudi SM, Saadat A, et al. "Coffee plus honey" versus " topical steroid" in the treatment of chemotherapy-induced oral mucositis: a randomised controlled trial. BMC Complement Altern Med. 2014; 14:293. doi: 10.1186/1472-6882-14-293
  • 60 . Samdariya S, Shirley Lewis, Heena Kauser, Iqbal Ahmed, and Dewesh Kumar. A randomized controlled trial evaluating the role of honey in reducing pain due to radiation induced mucositis in head and neck cancer patients. Indian J Palliat Care. 2015; 21(3): 268-273. doi: 10.4103/0973-1075.164892
  • 61 . Worthington HV, Clarkson JE, Bryan G, Furness S, Glenny AM, Littlewood A. et al. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev. 2011; 13(4):CD000978. doi: 10.1002/14651858. CD000978.pub2
  • 62 . Saunders DP, Epstein JB, Elad S, Allemano J, Bossi P, van de Wetering MD. et al. Systematic review of antimicrobials, mucosal coating agents, anesthetics, and analgesics for the management of oral mucositis in cancer patients. Support Care Cancer. 2013; 21:3191-3207. doi: 10.1007/s00520-013-1871-y
  • 63 . Can G. Onkoloji Hemşireliğinde Kanıta Dayalı Bakım İstanbul Konsensusu. İstanbul: Nobel Tıp Kitabevleri; 2010: 57-64.
  • 64 . Erdem Ö, Güngörmüş Z. The effect of royal jelly on oral mucositis in patients undergoing radiotherapy and chemotherapy. Holist Nurs Pract. 2014; 28(4):242-246. doi: 10.1097/HNP.0000000000000033
  • 65 . Cihan YB, Deniz K. The effects of royal jelly against radiation-induced acute oral mucositis. International Journal of Hematology and Oncology. 2014; 1(24):36-44. http://www.uhod.org/pdf/PDF_596.pdf
  • 66 . Watanabe S, Suemaru K, Takechi K, Kaji H, Imai K, Araki H. Oral mucosal adhesive fi lms containing royal jelly accelerate recovery from 5-fluorouracil-induced oral mucositis. J Pharmacol Sci. 2013;121(2):110-118. https://www.jstage.jst.go.jp/article/ jphs/121/2/121_12181FP/_pdf
  • 67 . Kaynar L, Çetin A, K. Hacıoğlu S, Eser B, Koçyiğit İ, Canöz Ö. et al. Effi cacy of royal jelly on methotrexate-induced systemic oxidative stress and damage to small intestine in rats. Afr J Tradit Complement Altern Med. 2012; 9(3):412-417. doi: 10.4314/ajtcam.v9i3.17
  • 68 . Suemaru K, Cui R, Li B, Watanabe S, Okihara K, Hashimoto K. et al. Topical application of royal jelly has a healing effect for 5-fl uorouracilinduced experimental oral mucositis in hamsters. Methods Find Exp Clin Pharmacol. 2008, 30(2):103-106. doi: 10.1358/ mf.2008.30.2.1159655
  • 69 . Yamauchi K, Kogashiwa Y, Moro Y, Kohno N. The effect of topical application of royal jelly on chemoradiotherapy-induced mucositis in head and neck cancer: A preliminary study. Int J Otolaryngol. 2014; Article ID 974967:1-5. doi:10.1155/2014/ 974967
  • 70 . Noronha VR, Araujo GS, Gomes RT, Iwanaga SH, Barbosa MC, Abdo EN, et al. Mucoadhesive propolis gel for prevention of radiationinduced oral mucositis. Curr Clin Pharmacol. 2014; 9(4):359-64. doi: 10.2174/1574884709666140205210051
  • 71 . Javadzadeh BA, Pakfetrat A, Tonkaboni A, Aledavood SA, Fathi Najafi M, Delavarian Z. et al. Preventing and therapeutic effect of propolis in radiotherapy induced mucositis of head and neck cancers: A tripleblind, randomized, placebo-controlled trial. Iran J Cancer Prev. 2015; 8(5):e4019. doi: 10.17795/ijcp-4019
  • 72 . Tomazevic T, Jazbec J. A double blind randomised placebo controlled study of propolis (bee glue) effectiveness in the treatment of severe oral mucositis in chemotherapy treated children. Complement Ther Med. 2013; 21(4):306-312. doi: 10.1016/j.ctim.2013 .04.002
Hemşirelikte Eğitim ve Araştırma-Cover
  • Yayın Aralığı: Yılda 4 Sayı
  • Yayıncı: Koç Üniversitesi HYO Semahat Arsel Hemşirelik Eğitim ve Araştırma Merkezi (SANERC)