Osman KUTSAL, Murat CALISKAN, Nihat YUMUSAK

Bir Ankara Kedisi’nde Malign Fibröz Histiositomun (Dev Hücreli Tip) İnce İğne Aspirasyon Sitolojisi

Bu olguda, 9 yaşlı, Ankara ırkı, dişi bir kedinin sırtında radyolojik, sitopatolojik ve histopatolojik olarak dev hücreli malign fibröz histiyositoma olgusu tanımlandı. Latero-lateral ve ventro-dorsal olarak tümöral kitlenin invazyonu radyolojik olarak belirlendi. Radyolojik incelemede kitle invaziv görüntüde olup kemiğe bağlantısı yoktu. Genel anestezi altında tümöral bölgeden İnce İğne Aspirasyon Sitolojisi (İİAS) tekniğine göre sitopatolojik örnekler alınarak May-Grunwald Giemsa yöntemine göre boyandı. Cerrahi operasyonla uzaklaştırılan biyopsi örneği ise rutin doku takibine alınarak hematoksilen eosin (HE) ile boyandı. Biyopsi materyali 8x6x6 cm ve 95 gr ağırlığında, deriyle kaplı, multilobuler yapıda ve sert kıvamlıydı. Kesit yüzü gri beyaz ve nekrotik manzaradaydı. Sitopatolojik incelemelerde anaplazik özelliklerde, pleomorfik şekilli histiyosit benzeri yada fibrosit benzeri çok sayıda hücreyle beraber, geniş ve vakuoler sitoplazmalı, çok çekirdekli dev hücreleri dikkati çekti. Histolojik incelemelerde ise, çeşitli yönlere girdaplar şeklinde dizilim yapmış atipik özellikler gösteren histiyosit benzeri veya bağ dokusu hücrelerinin aralarında, çok sayıda, geniş sitoplazmalı, 8-12 çekirdekli dev hücreleri fark edildi.

Anahtar Kelimeler:

Kedi, Sitoloji, Radyoloji, Histopatoloji, Malign fibröz histiositom

Fine-Needle Aspiration Cytology of Malignant Fibrous Histiocytoma (Giant Cell Type) in an Angora Cat

This case study presents the radiological, cytopathological and histopathological description of the giant cell type of a malignant fibrous histiocytoma on the back of a 9-year-old female Angora cat. Latero-lateral and ventro-dorsal thoracic radiographs was taken to evaluate invasion. Radiologically the mass was invasive but had not invaded the bone. Under general anaesthesia, cytopathological samples were taken from the tumour, using the Fine-Needle Aspiration Cytology (FNAC) technique, and were later stained with May-Grünwald Giemsa solution. The surgically extracted biopsy sample was subjected to routine tissue processing and stained with Haematoxylin-Eosin (HE). The biopsy material was 8x6x6 cm and 95 g, was covered by skin, multilobulary appearance and hard consistency. Cross-sections was greyish white and necrotic appearance. Cytopathological examination revealed the presence of numerous histiocyte- or fibrocyte-like cells of anaplastic character and pleomorphic shape, which were associated with giant cells with multiple nuclei and a broad and vacuolar cytoplasm. Histological examination demonstrated the presence of histiocyte-like atypical cells arranged in the form of swirls and extending in various directions, or numerous giant cells with 8 to 12 nuclei and a broad cytoplasm situated in between connective tissue cells.

Keywords:

Cat, Cytology, Radiology, Histopathology, Malignant fibrous histiocytoma,

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