Tavşanlarda Sistemik Olarak Kullanılan Midazolam, Ketamin ve İsofluranın Gözyaşı Üretimi ve Göziçi Basıncı Üzerine Olan Etkilerinin Deneysel Olarak Araştırılması

Bu çalışmanın amacı; tavşanlarda midazolam, ketamin ve isofluran anestezik ajanların gözyaşı üretimi ve göziçi basıncı üzerine olan etkilerini belirlemektir. Bu çalışmada yirmi adet (n = 20) sağlıklı, (ortalama ağırlıkları 2.20 ± 0.50 kg, yaşları 16 hafta) erkek Yeni Zelanda tavşanı kullanıldı. Birinci grupta intramuskuler (İM) midazolam 3mg/kg, ve ketamine İM 30 mg/ kg uygulanarak anestezi sağlandı. Ikinci grupta (Grup 2), midazolam ve ketamine enjeksiyonundan sonra genel anestezi için %2’lik İsofluran uygulandı. Anesteziden sonra her iki grupta da intraoküler basınç değerlerinde düşüşler görüldü. Birinci grupta (Grup I) göz içi basıncı sağ gözde 10.3 ± 0.85 mmHg ölçülürken, sol gözde 11.4 ± 0.95 mmHg olarak ölçüldü. İkinci grupta (Grup II) göziçi basıncı sağ gözde 8.5 ± 0.85 mmHg ölçülürken, sol gözde 8.3 ± 0.85 mmHg (sol göz) vardı. Bu çalışmanın sonucunda tavşanlarda sistemik olarak kullanılan midazolam, ketamin ve isofluran gibi anestezik ajanların GİB ve gözyaşı salgısını azalttığı görüldü.

Anahtar Kelimeler:

Anestezi, Göz içi basıncı, Tavşan, Gözyaşı üretimi

Effects of Systemically Used Midazolam, Ketamine and Isoflurane Anesthetic Agents on Intraocular Pressure and Tear Production in Rabbits

The aim of this study was to determine of the effects of midazolam, ketamine and isoflurane anesthetic agents on tear production and intraocular pressure in rabbits. In this study twenty healthy (n=20) male white New Zealand rabbits (mean weight 2.20 ± 0.50 kg, age 16 weeks) were used. Anesthesia was performed intramuscular (IM) midazolam 3 mg/kg, and ketamine 30 mg/kg in group I. In second group (Group II), after midazolam and ketamine injections isoflurane 2% was used for general anesthesia. After anesthesia means intraocular pressure (IOP) decreased in both groups. Intraocular pressure in first group (Group I) was 10.3 ± 0.85 mmHg (right eyes), 11.4 ± 0.95 mmHg (left eyes) while it was 8.5 ± 0.85 mmHg (right eyes), 8.3 ± 0.85 mmHg (left eyes) n group II. The result of this study show that systemically used midazolam, ketamine and isoflurane anesthetic agents decrease IOP and tear secretion in rabbits.

Keywords:

Anesthesia, Intraocular pressure, Rabbit, Tear production,

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