Ahmet UYANIKOĞLU, Mehmet Selim MAMİŞ, Esat Cihan KARAHANCI, Tuba DUMAK

Covid-19 Hastalarında Karaciğer Laboratuvar Anormalliklerinin Değerlendirilmesi

ÖZET Giriş:Covid-19 hastalığı, ribonükleikasid(RNA) genomu taşıyan koronavirüs (CoV) ailesinin neden olduğu bir hastalıktır. CoV’da en sık tutulan organ akciğer(AC) olmasına rağmen, gastrointestinel sistem(GİS) ve karaciğer(KC) de etkilenebilmektedir. Bu çalışmamızda Covid-19 hastalarında karaciğer fonksiyonlarının değerlendirilmesi amaçlanmıştır. Materyal-metod: Çalışmada 01.10.2020-01.12.2021 tarihleri arasında300 Covid-19 hastasının hastanaye ilk başvurudaki transaminaz(AST, ALT) ve kolestaz(ALP, GGT) enzimleri ile albümin düzeylerine bakıldı. Laboratuvar sonuçları, hastanemiz normal laboratuvar değerlerine göre gruplandırılarak incelendi. Araştırma için kurumsal izin alındı. Harran Üniversitesi Tıp Fakültesi Etik Kurulu'nun 21.03.2022 tarih ve 06 sayılı oturum kararı ile onay alındı. Bulgular:Hastaların 173’ü (%57,7) erkek ve 127’si (%42,3) kadın, yaş ortalaması 53±17,6(min 18 – max 95) yıl olarak saptandı. Hastaların 266 (%88,7) tanesi serviste, 31 (%10,3) tanesi servis ve yoğun bakım ünitesinde (YBÜ) ve 3 (%1) tanesi sadece YBÜ’de takip edildi. Toplam takip süresi ortalaması 7,22±17,68 gün olup, servis takip süresi 6,69±2,63 gün idi. Cinsiyete göre laboratuvar değerlerinin ortalama ve standart sapmaları tablo 1’de verilmiştir. Hastaların %69’unda AST, %29’unda ALT, %16,3 ALP ve %28,3 GGT yüksekliği saptanırken, %19,3 oranında albümin düşüklüğü saptandı. AST, ALT ve GGT yükseklikleri daha çok erkeklerde görülürken, albümin düşüklüğü de daha çok kadınlarda görüldü. Sonuç:CoV bağlı KC disfonksiyonu geliştiğinde sırasıyla daha çok AST, ALT, GGT ve albümin anormallikleri görülmektedir. CoV’a bağlı özellikle AST olmak üzere transaminazların, kolestaz enzimlerine göre daha sık arttığı saptanmıştır.

Anahtar Kelimeler:

Covid-19, karaciğer, laboratuvar anormallikleri

Evaluation of Liver Laboratory Abnormalities in Covid-19 Patients

SUMMARY Introduction: Covid-19 disease is a disease caused by the coronavirus (CoV) family, which carries the ribonucleic acid (RNA) genome. Although the lung is the most frequently involved organ in CoV disease, the gastrointestinal tract (GIS) and liver can also be affected. This study is aimed to evaluate liver functions in Covid-19 patients. Material-method: In the study, transaminase (AST, ALT) and cholestasis (ALP, GGT) enzymes and albumin levels of 300 Covid-19 patients at their first admission to the hospital were examined between 01.10.2020 and 01.12.2021. Laboratory results were analyzed by grouping them according to the normal laboratory values of our hospital. Institutional permission was obtained for the study. Approval was obtained by the Ethics Committee of Harran University Faculty of Medicine with the session decision dated 21.03.2022 and numbered 06. Results: 173 (57.7%) of the patients were male and 127 (42.3%) were female, their mean age was 53±17.68 years. Of the patients, 266 (88.7%) were followed up in the ward, 31 (10.3%) in the ward and intensive care unit (ICU), and 3 (1%) only in the ICU. The mean total monitorization period was 7.22±17.68 days, and the service monitorization period was 6.69±2.63 days. The mean and standard deviations of laboratory values by gender are given in table 1. While 69% of the patients had AST elevation, 29% had ALT elevation, 16.3% had ALP elevation and 28.3% had GGT elevation the albumin rate was found to be low in 19.3% of the patients. While AST, ALT and GGT elevations were more common in men, low albumin levels were more common in women. Conclusion: When CoV-induced liver dysfunction develops, AST, ALT, GGT and albumin abnormalities are seen, In chronological order. It was thus determined that transaminases, especially AST, increased more frequently than cholestasis enzymes due to CoV.

Keywords:

Covid-19, liver, laboratory abnormalities,

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