Mustafa Raşid TOKSÖZ, Muhammed Nebil SELİMOĞLU, Abit AKTAŞ, Funda YİĞİT, Nedim SAVACI

Periferik Sinir Yaralanmalarında Kalsiyum Kanal Blokerleri İle Birlikte Sigara Dumanı Maruziyetinin Sinir İyileşmesine Olan Etkisinin Araştırılması

Amaç: Bu çalışma deneysel olarak oluşturulan siyatik sinir kesisin de sigara dumanı maruziyeti ile birlikte kalsiyum kanal blokerlerinin etkisini araştırmak için planlandı. Gereç-Yöntem: Tüm gruplarda siyatik sinir tek taraflı kesildi ve 0. saatte onarım yapıldı. Onarım sonrası grup 1 e sadece günde tek doz 1 ml %0.9 serum fizyolojik, grup 2 ye 90 gün 30 dakika sigara dumanı, grup 3 e 1mg/kg Kalsiyum Kanal Blokeri, grup 4 e 90 gün 30 dakika sigara dumanı ve 1mg/kg Kalsiyum Kanal Blokeri verildi. 12. hafta sonunda Yürüme Analizi ve Siyatik Fonksiyon İndeksi (SFİ), miyelinli akson sayıları, akason alanları ve miyelin çapları değerlendirildi. Bulgular: Ölçülen SFİ değerlerinden grup 1 ile grup 3 ve 4 arasında anlamlı fark olduğu, grup 2 ile grup 3 ve 4 arasında anlamlı fark olduğu tespit edildi (p<0.05). Ayrıca grup 2 deki akson sayısı ile grup 3 teki akson sayısı arasında da anlamlı fark bulundu(p<0.05). Sonuç: Siyatik fonksiyon indeksi açısından periferik sinir kesilerinde onarım sonrası kalsiyum kanala blokerleri olumlu sigara dumanı da olumsuz yönde etki yapmaktadır. Ayrıca siyatik fonksiyon indeksine göre sigara dumanın yaptığı bu olumsuz yönde etki kalsiyım kanal blokerleri ile giderilebilir. Ancak bu veriler akson sayısı akson alanı ve miyelin çapı ile desteklenmemektedir

Anahtar Kelimeler:

periferik sinir, sigara dumanı, kalsiyum kanal blokeri

Investigation of the Effects of Calcıum Channel Blockers with Cigarette Smoke Exposure to Nerve Healing at Peripheral Nerve Injuries

Objective: A study was planned to investigate the effect of exposure to cigarette smoke and the effects of calcium channel blockers in experimentally induced sciatic nerve injuries. Material-Method: The sciatic nerve was cut on one side in all the groups, and repair was performed in hour 0. After repair, a single daily dose of 1 ml of 0.9% saline was administered to group 1, 90 days, 30 minutes, cigarette smoke to group 2, 1mg/kg calcium channel blocker to group 3, 90 days, 30 minutes, cigarette smoke and 1mg/kg Calcium channel blocker was given to group 4. Results: At the end of the 12th week, gait analysis at and sciatic function index (SFI), the number of myelinated axons, axon areas and myelin diameters were assessed. There was a significant difference between the measured values of SFI in group 1 and group 3 and 4, and there was a significant difference between group 2 and group 3 and 4 (p <0.05). In addition there was a significant difference between the number of axons in group 2 and group 3 (p <0.05). Conclusion: As a result, after peripheral nerve laceration repair calcium channel blockers have a positive effect on the sciatic function index while cigarette smoke has a negative effect. In addition, according to the sciatic function index the negative effect of cigarette smoke can be resolved with calcium channel blockers. But; these data are not supported by the number of axon, axon area, and the myelin diameter

Keywords:

peripheral nerve, cigarette smoke, calcium channel blocker,

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