CaSR gen polimorfizmin koroner arter hastaların patogenezinde rolünün araştırılması

Amaç: Koroner arter hastalığı (KAH) dünya çapında sık görülen kalp hastalığı tiplerinden biridir. Gelişmekte olan ülkelerdeki yüksek prevalansı nedeniyle, dünya genelinde en fazla görünen nedenlerden biri olarak kabuledilmektedir.Primerhiperparatiroidizm gibi kalsiyum homeostaz bozuklukları, kardiyovasküler nedenlere bağlı ölüm riskini artırabilir. Bu çalışmada kroner arter hastaların patogenezinde CaSR genine ait rs1048213, rs9883099 gen plimorfizminin rolünün araştırılması ve tüm nedenlere bağlı ölüm veya mortalite ile ilişkili olup olmadığını belirlenmesini amaçladık. Gereç ve Yöntem: Çalışma135 KAH olan olgu ile herhangi bir Kalp rahatsızlığı olmayan sağlıklı 139 gönüllü verileri karşılaştırıldı,- CaSR genine ait rs1048213, rs9883099 polimorfizmi ise hastalardan alınan kan örneklerinden elde edilen DNA lar gerçek zamanlı polimeraz zincir reaksiyonu (PCR) ile araştırıldı. Bulgular: Biyokimyasal parametreler vücut kitle indeksi(VKİ), Hipertansiyon; Diyabet, Sigara içme, Toplam kolesterol, Trigliseritler, HDL‐kolesterol, LDL‐kolesterol değerleri kontrollere göre anlamlılık tespit edilmiştir(p

Objective: Coronary artery disease is one of the most commonly seen heart diseases worldwide. Given high prevalence in developing countries, it is considered as most frequent causes of death worldwide. Disorders of calcium homeostasis such as primary hyperparathyroidism can increase mortality risk due to cardiovascular causes. In this study, we aimed to investigate role of rs1048213 and rs9883099 polymorphisms in CaSR gene in the pathogenesis of coronary artery disease and to determine whether they are associated to all-causes death and mortality. Material and Method: Data from patients with 135 coronary artery disease and 139 healthy volunteer without heart disease were compared in this study. rs1048213 and rs9883099 polymorphisms were screened by using real-time PCR in blood samples obtained from patients. Results: Significant differences were detected in biochemical parameters, BMI, hypertension, diabetes mellitus, smoking, total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol when compared to controls (p

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