Orta lob sendromlu olgularda bilgisayarlı tomografi bulguları
Amaç: Orta lob sendromu (OLS), sağ akciğer orta lobunun kronik veya tekrarlayan atelektazileri ile karakterize bir tablodur. Spesifik bir klinik bulgusu yoktur. OLS tanısında Bilgisayarlı Tomografi (BT) en sık kullanılan modalitedir. Kliniğimizde son iki yılda OLS tanısı almış hastaların BT bulgularını literatür eşliğinde sunmayı amaçladık. Gereç ve Yöntem: Mayıs 2015- Mayıs 2017 tarihleri arasında hastanemiz radyoloji kliniğine başvuran ve OLS tanısı alan 29 hastanın, BT ve klinik bulguları retrospektif olarak iki radyolog ve bir göğüs hastalıkları uzmanı tarafından incelendi. Bulgular: OLS tanısı alan 29 hastanın 17’si (%58,6) kadın, 12’si (%41,4) erkek hastaydı. Kadın/erkek oranı 1.42 idi. Bu olguların yaş ortalaması ise 59,4±17,01 (8-84 yaş) olarak hesaplandı. Klinik değerlendirmede en sık semptom öksürük, nefes darlığı ve balgam olarak saptandı. Radyolojik görüntülemede tüm hastaların BT tetkiklerinde sağ akciğer orta lobda atelektazi mevcuttu. Atelektazi ile birlikte diğer en sık eşlik eden bulgular ise 11 hastada mediastinal ve/veya hiler patolojik görünümde lenfadenopati, 6 hastada bronşektazi, 4 hastada enfeksiyon ile uyumlu parankimal bulgular, 3 hastada parankimal nodüller, 3 hastada peribronşial kalınlaşma, 2 hastada operasyon sonrası değişiklikler, 2 hastada diafragmaevantrasyonu, 2 hastada mukus tıkacı, 1 hastada squamöz hücreli kanser, 1 hastada da pulmoneremboli idi. Dört hastada herhangi bir ek akciğer patolojisi saptanmadı. Sonuç: OLS, sağ akciğer orta lobun total atelektazisi olup spesifik klinik bulguları olmaması nedeniyle kronik ve tekrarlayan akciğer şikayetleri olan her hastada özellikle sağ akciğerde yerleşim gösteren lezyonlarda ayırıcı tanılar arasında göz önünde bulundurulmalıdır. BT’nin rutine girmesi ile de radyolojik olarak görülme sıklığı artmıştır. BT, OLS tanısında etkin ve noninvaziv bir görüntüleme yöntemidir.
Objective: Middle lobe syndrome (MLS) is a condition characterized by chronic or recurrent atelectasis of the right middle lobe of the lung. There is nonspecific clinical finding. Computed Tomography (CT) is the most commonly used modality in MLS diagnosis. We Aimed To Present The CT findings of : patients who have been diagnosed MLS in our clinic for the past two years with literature. Materials and Method: Between May 2015 and May 2017, CT and clinic findings of 29 patients who are diagnosed MLS reviewed retrospectively by two cardiologist and a chest diseases doctor. Results: 17 of the 29 patients (58,6%) were female and 12 (41,4%) were male who are diagnosed with MLS. Female/male ratio was 1,42. The Mean Age of these cases was 59,4 ± 17,01 (8-84 age range). In Clinical Assessment The Most Common Symptoms Were Cough, shortness ofbreath and sputum. Radiologically, all patients had atelectasis in the right middle lobe of lung at the CT examination. The Most Common Accompanying Findings with atelectasis were mediastinum and/or hilar lymphadenopathy in 11 patients, bronchiectasis in 6 patients, parenchymal findings compatible with infection in 4 patients. Any Lung Pathology Wasn't detected in 4 patients. Conclusion: MLS is a total atelectasis of the middle lobe of right lung and there is nonspecific clinical findings. İt Should be absolutely considered among the differential diagnosis in patients with chronic and recurrent lung complaints, especially in the located lesions that in right lung. The frequency of radiological appearance increased with the routinizing of CT. CT is an effective and non-invasive imaging method for diagnosis of MLS.
___
- Yamada Y, Izawa H, Ichihara S, et al. Prediction of the risk
of myocardial infarction from polymorphisms in candidate
genes. N Engl J Med 2002; 347:1916–192.
- Murray CJ, Lopez AD. Measuring the global burden of disease.
N Engl J Med 2013; 369(5):448–57.
- Poulter N. Coronary heart disease is a multifactorial disease.
American Journal of Hypertension 1999;12(S6):92–5.
- Arnett D. K., Baird A. E., Barkley R. A., et al. Relevance
of genetics and genomics for prevention and treatment
of cardiovascular disease: a scientific statement from the
American Heart Association Council on Epidemiology and
Prevention, the Stroke Council, and the Functional Genomics
and Translational Biology Interdisciplinary Working
Group. Circulation 2007;115(22):2878–901.
- Deloukas P., Kanoni S., et al. Large-scale association analysis
identifies new risk loci for coronary artery disease.
Nature Genetics 2013;45(1):25–33.
- Nikpay M, Goel A, Won HH, et al. A comprehensive 1,000
genomesbased genome-wide association meta-analysis of
coronary artery disease. Nature Genetics 2015;47(10):1121–
30.
- Castelli WP. Cholesterol and lipids in the risk of coronary
artery disease—the Framingham Heart Study. Can J Cardiol
1988; (Suppl A):5A–10A.
- Linsel-Nitschke P, Tall AR. HDL as a target in the treatment
of atherosclerotic cardiovascular disease. Nat Rev Drug
Discov 2005; 4(3):193–205.
- Roberts R. A genetic basis for coronary artery disease.
Trends Cardiovasc Med 2015; 25(3):171–8.
- Acton S, Rigotti A, Landschulz KT, et al. Identification of
scavenger receptor SR-BI as a high density lipoprotein receptor.
Science 1996; 271(5248):518–20.
- Winfried März, Ursula Seelhorst Britta Wellnitz et al. Alanine
to Serine Polymorphism at Position 986 of the Calcium-Sensing
Receptor Associated with Coronary Heart
Disease, Myocardial Infarction, All-Cause, and Cardiovascular
Mortality. J Clin Endocrinol & Metabol 2007; 92 (6):
2363–9.
- Bai M. Structure-function relationship of the extracellular
calcium-sensing receptor. Cell Calcium 2004;35:197-207.
- Pearce SH, Thakker RV. The calcium-sensing receptor: insights
into extracellular calcium homeostasis in health and
disease. J Endocrinol 1997; 154: 371-8.
- Cho HJ, Kim SY, Young B., et al. The opposite correlation
between calcium ion and cyclic-AMP regarding the activation
of microsomal triglyceride transfer protein in rat liver.
BMB Rep 2009; 42: 642-7.
- Cifuentes M, Rojas CV. Antilipolytic effect of calcium-sensing
receptor in human adipocytes Mol Cell Biochem 2008;
319: 17-21.
- He YH, Song Y, Liao XL., et al. The calcium-sensing receptor
affects fat accumulation via effects on antilipolytic pathways
in adipose tissue of rats fed low-calcium diets. J Nutr
2011; 141: 1938-46.
- He Y, Zhang H, Teng J, Huang L, Li Y, Sun C. Involvement
of calciumsensing receptor in inhibition of lipolysis through
intracellular cAMP and calcium pathways in human adipocytes.
Biochem Biophys Res Commun 2011; 404: 393-9.
- Malecki R, Fiodorenko-Dumas Z, Jakobsche-Policht U, Malodobra
M, Adamiec R. Altered monocyte calcium-sensing
receptor expression in patients with type 2 diabetes mellitus
and atherosclerosis. J Physiol Pharmacol 2013;64(4):521-7.
- Hedback G, Oden A. Death risk factor analysis in primary
hyperparathyroidism. Eur J Clin Invest 1998; 28:1011–8.
- Schulz E, Arfai K, Liu X, Sayre J, Gilsanz V. Aortic calcification
and the risk of osteoporosis and fractures. J Clin
Endocrinol Metab 2004; 89:4246–53.
- Banks LM, Lees B, MacSweeney JE, Stevenson JC. Effect of
degenerative spinal and aortic calcification on bone density
measurements in post-menopausal women: links between
osteoporosis and cardiovascular disease ? Eur J Clin Invest
1994; 24:813–7.
- Jie KG, Bots ML, Vermeer C, Witteman JC, Grobbee DE.
Vitamin K status and bone mass in women with and without
aortic atherosclerosis: apopulation-based study. Calcif
Tissue Int 1996; 59:352–6.
- Hak AE, Pols HA, van Hemert AM, Hofman A, Witteman
JC. Progression of aortic calcification is associated with metacarpal
bone loss during menopause: a population-based
longitudinal study. Arterioscler Thromb Vasc Biol 2000;
20:1926–31.
- Alam MU, Kirton JP, Wilkinson FL, et al. Calcification is
associated with loss of functional calcium-sensing receptor
in vascular smooth muscle cells. Cardiovasc Res 2009;
81(2): 260-8.
- Mallika V, Goswami B, Rajappa M. Atherosclerosis pathophysiology
and the role of novel risk factors: A clinicobiochemical
perspective. Angiology 2007; 58: 513-22.
- Ceylan Y, Kaya Y, Tuncer M. Akut Koroner Sendrom Kliniği
ile Başvuran Hastalarda Koroner Arter Hastalığı Risk
Faktörleri. Van Tıp Dergisi 2011; 18(7):3.
- Onat A, Yüksel M, Köroğlu M, ve ark. TEKHARF: Genel ve
koroner mortalite ile metabolik sendrom prevalansı eğilimleri.
Türk Kardiyoloji Derneği Arşivi 2013; 41: 1-3.
- Özkan A. Akut koroner sendromlar: Epidemiyoloji. Türk
Kardiyoloji Derneği Arşivi 2013; 41(1): 1-3.
- Buğan B, Çelik T. Koroner Arker Hastalığı Risk Faktörleri. J
Clin Analytic Med 2014; 5(2): 159-63.
- Tanboğa İH, Can MM, Özkan A, ve ark. Koroner arter hastalarında
insan trombosit antijen-1 gen polimorfizmi ile
klopidogrel direnci ilişkisi, Turk Kardiyol Dern Ars 2013;
41(5): 379-85.
- Ayçiçek GŞ, Başkal N. Primer hiperparatiroidizmde P27/
KİP1 ve casr ekspresyonu;klinik, laboratuvar parametreler
ve kemik yoğunluğu ile ilişkileri / P27/KİP1 and casr expressıon
in primary hyperparathyroidism; the relationship
between clinic, laboratory parameters and bone density,
Ankara Üniversitesi /Tıp Fakültesi /İç Hastalıkları Anabilim
Dalı Tıpta Uzmanlık 2014 69 s.
- Karadag B, Güven M, Hacioglu Y, ve ark. Relationship
between two estrogen receptor-[alpha] gene polymorphisms
and angiographic coronary artery disease/Iki östrojen
reseptör-[alpha] gen polimorfizminin anjiyografik koroner
arter hastaligi ile olan ilişkisi. Anatolian J Cardiol 2009;
9(4): 267-72.
- Lawlor DA, Davey Smith G, et al. Plasma adiponectin levels
are associated with insulin resistance, but do not predict future
risk of coronary heart disease in women. J Clin Endocrinol
Metab 2005; 90:5677–83.
- Şenol S, Tekümit H, Kara M, ve ark. Adiponectin and leptin
polymorphisms in patients with coronary artery disease
Koroner arter hastalarında adiponektin ve leptin polimorfizmleri.
Turk Gogus Kalp Damar 2015;23(4):637-42.
- Sattar N, Wannamethee G, Sarwar N, et al. Adiponectin
and coronary heart disease: a prospective study and metaanalysis.
Circulation 2007; 115(10):e322.
- Ko YL, Ko YS, Wang SM, et al. Angiotensinogen and angiotensin-I
converting enzyme gene polymorphisms and
the risk of coronary artery disease in Chinese. Hum Genet
1997;100: 210-4.
- He YH1, Kong WL, Wang G, et al. The calcium-sensing receptor
R990G polymorphism is associated with increased
risk of hypertriglyceridemia in obese Chinese. Gene 2014;
533(1): 67-71.
- Babinsky VN, Hannan FM, Youhanna SC, et al. Association
Studies of Calcium-Sensing Receptor (CaSR) Polymorphisms
with Serum Concentrations of Glucose and Phosphate,
and Vascular Calcification in Renal Transplant Recipients.
PLoS One. 2015; 10(3): e0119459.
- Aslan EI, Aydoğan HY. Koroner kalp hastalarında kalsiyum-duyarlı
reseptör (CASR) gen lokusunda CASR-fonksiyonunu
değiştiren gen varyasyonlarının incelenmesi /
Investigating the function-changing genetic variations on
the calcium-sensing receptor (CASR) locus in coronary
heart disease patients, İstanbul Üniversitesi / Sağlık Bilimleri
Enstitüsü /Moleküler Tıp Anabilim Dalı, Yüksek Lisans
2015 88 s.