Melahat KURTULUŞ, Mehmet GÜNAY, Ebru ÇETİN, Çağrı ÇELENK, İbrahim CİCİOĞLU, Ebru ALP, Meral YİRMİBEŞ KARAOĞUZ, Tahsin KESİCİ

Elit Türk Sporcularında Anjiotensin Dönüştürücü Enzim (I / D) Polimorfizmi ile Sportif Performans Arasındaki İlişkinin İncelenmesi

Anjiotensin dönüştürücü enzim fiziksel aktivite ile ilişkili önemli bir gendir. ACE geni intron 16’da plazma ve dokularda ACE düzeylerini belirleyen bir polimorfizme (I/D) sahiptir. Bu çalışmanın amacı elit Türk sporcularından (dayanıklılık ve kuvvet sporcusu) oluşan bir populasyonda (kayak, hentbol, voleybol, güreş) ACE geni I/D polimorfizmi ile spor performansı arasında bir ilişki olup olmadığını belirlemektir. Periferal kandan DNA elde edildi ve her bir bireyin ACE genotip dağılımı polimeraz zincir reaksiyonu yöntemiyle belirlendi. 114 elit Türk sporcusu dayanıklılık (18) ve kuvvet sporcuları (96) olarak iki gruba ayrıldı. Sporcuların ACE geni genotip ve alel frekansları; 114 elit sporcu, her bir sporcu grubu, dayanıklılık sporcuları ve kuvvet sporcuları olmak üzere dört ayrı katagoride kontrol grubu ile karşılaştırıldı. Ayrıca her bir spor grubundaki sporcular ile dayanıklılık ve kuvvet sporcuları birbirleriyle Ki-kare and Fisher exact testi ile karşılaştırıldı. Elit Türk sporcu ve kontrol grubu arasında ve diğer kategoriler arasında yapılan karşılaştırmalarda ACE geni genotip dağılımı ve alel frekanslarında istatistiksel olarak anlamlı bir fark tespit edilmedi (p > 0.05).

Anahtar Kelimeler:

Anjiotensin Konverting Enzim, Sporcu, Polimorfizm

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