Ayla GÜLEKON, Hüseyin ADIŞEN, Aysel ARICI, mehmet Ali GÜRER, Deniz ERBAŞ, Özlem GÜLBAHAR

The effects of colchicine and vitamin E on the lipid peroxidation and antioxidant enzymes in patients with Behçet's disease

Amaç: Behçet hastalığının etyopatogenezi bilinmemektedir. Bununla birlikte aktif nötrofıllerin artmış serbest radikal üretimleri üzerinde durulmaktadır. Bu çalışmanın amacı Behçet hastalrmda oksidan/antioksidan durumun değerlendirilmesi ve kolşisin ve 400 IU E vitaminin bu sistemler üzerine etkisinin değerlendirilmesidir. Gereç ve yöntemler: Bu amaçla aktif dönemdeki 20 Behçet hastası ve 20 sağlıklı kontrolde plazma malondialdehit (MDA), süperoksid dismütaz (SOD) ve glutatyon peroksidaz (GSH-Px) seviyeleri ölçülmüştür. Behçet hastalarında bu değerler üç ay süreyle kolşisin veya kolşisin + E vitamini tedavisini takiben tekrar ölçülmüştür. Bulgular: Kontrol grubu ile karşılaştırıldığında aktif dönem Behçet hastalarında MDA seviyeleri yüksek, SOD ve GSH-Px aktiviteleri ise daha düşük olarak tespit edilmiştir. ,(p

Behçet hastalarında sistemik kolşisın ve kolşisin + vitamin E'nin lipid peroksidasyonu ve antioksidan enzimleri üzerine etkileri

Purpose: The etiopathogenesis of Behçet's disease (BD) remains unknown, while increasing attention has been focused on the role of excessive production of free radicals produced by activated neutrophils. The purpose of the study was to assess the oxidant/antioxidant status in BD and to evaluate the effects of colchicine and vitamin E therapies on these systems. Materials and Methods: The levels of plasma malondialdehyde (MDA), and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in 20 patients in the active stage of the disease and in 20 healthy controls. These measurements were repeated in patients with BD after three months of therapy with either colchicine 1.5 mg/day or colchicine plus 400 IU vitamin E. Results: Higher MDA levels and lower SOD and GSH-Px activities were observed in the patients when compared with the controls (p

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