Osteoporoz için Olası Katkısı Bulunan Lipid Profilleri
Amaç: Kemik yoğunluğunun azalması toplumda büyük bir sağlık sorunudur. Serum lipidleri ile kemik mineral yoğunluğu arasındaki ilişki hakkında genel bir uzlaşı yoktur. Bu çalışma, lipid profili ve osteoporoz arasındaki ilişkiyi araştırmak amacıyla yapıldı. Yöntem: Bu kesitsel çalışmada, 1500 denek Tahran'da rastgele seçildi. KMY, lunar cihazı kullanılarak DEXA ile pelvik, omurga ve toplam vücutta ölçülmüştür. SPSS v19.0'a aktarılan toplanan veriler ve lineer regresyon analitik bir test olarak gerçekleştirildi. İstatistiksel anlamlılık, 0.05'ten küçük p değerleri olarak tanımlandı. Bulgular: Bu çalışmaya toplam 1500 denek (40.88 ± 11.58 yıl) katılırken, olguların% 62'si kadın (n = 930) ve % 38'i erkektir (n = 570). Yaş, cinsiyet ve menopoz durumu pelvik KMY ile ilişkiliydi (p değeri
Lipid Profiles as a Possible Contributor to Osteoporosis
Objectives: Reducing bone density is a major health problem in society. Thereis no general agreement on the relationship between serum lipids and bonemineral density. This study was conducted to investigate the associationbetween lipid profile and osteoporosis.Material and Methods: In this cross-sectional study, 1500 subjects wererandomly selected from Tehran. BMD was measured in pelvic, spine and totalbody by DEXA using the lunar device. Collected data imported to SPSS v19.0and linear regression was performed as an analytic test. Statistical significantwas defined as P-values less than 0.05.Results: Totally 1500 subjects participate in this study (age 40.88±11.58yr),62% of subjects were female (n=930) and 38% were male (n=570). Age, sexand menopausal status were related to pelvic BMD (p-value
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- Jamshidian-Tehrani M, Kalantari N, Azadbakht L, Esmaillzadeh A, Rajaie A,
Houshiar-Rad A, et al. Osteoporosis risk factors in Tehrani women aged 40-60
years. Iranian Journal of Endocrinology and Metabolism. 2004;6:139-45.
- Soltani AAF, Pazhouhi M, Bastan HM, Mirfeizi SZ, Dashti R, Hosseinnezhad
A. Bone mineral density variations in 20-69 yr. population of Tehran/Iran.
2002.
- Zamani B, Ebadi SA, Ahmadvand A, Moosavi GA. The Frequency of
Osteoporosis in Hip Fracture Following Minor Trauma and The Resulting
Mortality Rate and Direct Treatment Costs In Patients Over 45 Years Old In
Kashan Naghavi Hospital During 2005-2007. Journal of Kerman University of
Medical Sciences. 2010;17:137-44.
- Melton LJ. The prevalence of osteoporosis. Journal of Bone and Mineral
Research. 1997;12:1769-71.
- Taghizadeh.Z ZM, Mortaz Hejri.S, Maghboli.G, Kazemnezhad.A,
Pazhohi.M,. investigating the air pollution with bone density measurements
and bone biochemistry indicators in various residents of Tehran. University of
Medical Sciences, Journal of Reproduction and infertility. 2004;1:43-52.
- Amiri M LB, Nabipour I, Moosavi SF, Amiri Z, Soltanian A, et al. The
prevalence of osteoporosis in 20-69 years old women in Bushehr port.
2004;7:61-9.
- Urano T, Inoue S. Recent genetic discoveries in osteoporosis, sarcopenia
and obesity. Endocrine journal. 2015;62:475-84.
- Baccaro LF, Conde DM, Costa-Paiva L, Pinto-Neto AM. The epidemiology and
management of postmenopausal osteoporosis: a viewpoint from Brazil.
Clinical interventions in aging. 2015;10:583.
- Jeynes KD, Gibson EL. The importance of nutrition in aiding recovery from
substance use disorders: A review. Drug and alcohol dependence.
2017;179:229-39.
- Rizzoli R, Bischoff-Ferrari H, Dawson-Hughes B, Weaver C. Nutrition and
bone health in women after the menopause. Women’s Health. 2014;10:599-
608.
- Ehrampoush E, Homayounfar R, Davoodi SH, Zand H, Askari A, Kouhpayeh
SA. Ability of dairy fat in inducing metabolic syndrome in rats. SpringerPlus.
2016;5:2020.
- Coughlan T, Dockery F. Osteoporosis and fracture risk in older people.
Clinical medicine. 2014;14:187-91.
- Tella SH, Gallagher JC. Prevention and treatment of postmenopausal
osteoporosis. The Journal of steroid biochemistry and molecular biology.
2014;142:155-70.
- Patsch JM, Deutschmann J, Pietschmann P. Gender aspects of
osteoporosis and bone strength. Wiener medizinische Wochenschrift.
2011;161:117-23.
- Krejci CB, Bissada NF. Women's health: periodontitis and its relation to
hormonal changes, adverse pregnancy outcomes and osteoporosis. Oral
health & preventive dentistry. 2012;10(1).
- Segev D, Hellerstein D, Dunsky A. Physical activity-does it really increase
bone density in postmenopausal women? A Review of articles published
between 2001-2016. Current aging science. 2017.
- Park C-H, Lee Y-K, Koo K-H. Knowledge on osteoporosis among nurses.
Journal of bone metabolism. 2017;24:111-5.
- Beaudart C, Dawson A, Shaw S, Harvey N, Kanis J, Binkley N, et al. Nutrition
and physical activity in the prevention and treatment of sarcopenia:
systematic review. Osteoporosis International. 2017;28:1817-33.
- Compston JE, McConachie C, Stott C, Hannon RA, Kaptoge S, Debiram I, et
al. Changes in bone mineral density, body composition and biochemical
markers of bone turnover during weight gain in adolescents with severe
anorexia nervosa: a 1-year prospective study. Osteoporosis international : a
journal established as result of cooperation between the European
Foundation for Osteoporosis and the National Osteoporosis Foundation of the
USA. 2006;17:77-84.
- Del Valle HB, Yaktine AL, Taylor CL, Ross AC. Dietary reference intakes for
calcium and vitamin D: National Academies Press; 2011.
- Osati S, Homayounfar R, Hajifaraji M. Metabolic effects of vitamin D
supplementation in vitamin D deficient patients (a double-blind clinical trial).
Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2016;10:S7-
S10.
- Wallach JB. Interpretation of diagnostic tests: Lippincott Williams &
Wilkins; 2007.
- Saghafi H, Hossein-Nezhad A, Rahmani M, Larijani B. Relationship between
lipid profile and bone turnover in pre and postmenopausal women. Iranian J
Publ Health Suppl. 2008:23-9.
- Semler JC. Risk factors for osteoporosis in men. Bone and Mineral.
1992;17:178.
- Brownbill RA, Ilich JZ. Lipid profile and bone paradox: higher serum lipids
are associated with higher bone mineral density in postmenopausal women.
Journal of Women's Health. 2006;15:261-70.
- Samelson EJ, Cupples LA, Hannan MT, Wilson PWF, Broe KE, Zhang YQ, et
al., editors. Long-term effects of serum cholesterol over 34 years on bone
mineral density (BMD) in women and men: the framingham osteoporosis
study. Journal of bone and mineral research; 2002: Amer Soc Bone & Mineral
Res 2025 M St, Nw, Ste 800, Washington, DC 20036-3309 USA.
- Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration
of low-density lipoprotein cholesterol in plasma, without use of the
preparative ultracentrifuge. Clinical chemistry. 1972;18:499-502.
- Samelson EJ, Cupples LA, Hannan MT, Wilson PWF, Williams SA, Vaccarino
V, et al. Long-term effects of serum cholesterol on bone mineral density in
women and men: the Framingham Osteoporosis Study. Bone. 2004;34:557-
61.
- Pérez-Castrillón J-L, De Luis D, Martın-Escudero JC, Asensio T, del Amo R, ́
Izaola O. Non-insulin-dependent diabetes, bone mineral density, and
cardiovascular risk factors. Journal of diabetes and its complications.
2004;18:317-21.
- Tanko LB, Bagger YZ, Nielsen SB, Christiansen C. Does serum cholesterol
contribute to vertebral bone loss in postmenopausal women? Bone.
2003;32:8-14.
- Sahmani M, Omidian S, Javadi A, Sabet MS, Abbasi M. Association between
the serum levels of zinc, copper and lipid profile with osteoporosis in Iranian
postmenopausal women. Biotechnology and Health Sciences. 2014;1:8,12.
- Yamaguchi T, Sugimoto T, Yano S, Yamauchi M, Sowa H, Chen Q, et al.
Plasma lipids and osteoporosis in postmenopausal women. Endocrine journal.
2002;49:211-7.
- Orozco P. Atherogenic lipid profile and elevated lipoprotein (a) are
associated with lower bone mineral density in early postmenopausal
overweight women. European journal of epidemiology. 2004;19:1105-12.
- Cui L-H, Shin M-H, Chung E-K, Lee Y-H, Kweon S-S, Park K-S, et al.
Association between bone mineral densities and serum lipid profiles of preand
post-menopausal rural women in South Korea. Osteoporosis
International. 2005;16:1975-81.
- Adami S, Braga V, Zamboni M, Gatti D, Rossini M, Bakri J, et al. Relationship
between lipids and bone mass in 2 cohorts of healthy women and men.
Calcified tissue international. 2004;74:136-42.
- Giachelli CM, Liaw L, Murry CE, Schwartz SM, Almeida M. Osteopontin
Expression in Cardiovascular Diseasesa. Annals of the New York Academy of
Sciences. 1995;760:109-26.
- Tanko LB, Bagger YZ, Christiansen C. Low bone mineral density in the hip
as a marker of advanced atherosclerosis in elderly women. Calcified tissue
international. 2003;73:15-20.
- Parhami F. Possible role of oxidized lipids in osteoporosis: could
hyperlipidemia be a risk factor? Prostaglandins, leukotrienes and essential
fatty acids. 2003;68:373-8.
- D’Amelio P, Pescarmona GP, Gariboldi A, Isaia GC. High density
lipoproteins (HDL) in women with postmenopausal osteoporosis: a
preliminary study. Menopause. 2001;8:429-32.
- Parhami F, Garfinkel A, Demer LL. Role of lipids in osteoporosis.
Arteriosclerosis, thrombosis, and vascular biology. 2000;20:2346-8.
- Arjmandi BH, Juma S, Beharka A, Bapna MS, Akhter M, Meydani SN.
Vitamin E improves bone quality in the aged but not in young adult male mice.
The Journal of nutritional biochemistry. 2002;13:543-9.
- Parhami F, Demer LL. Arterial calcification in face of osteoporosis in ageing:
can we blame oxidized lipids? Current opinion in lipidology. 1997;8:312-4.
- Watson AD, Leitinger N, Navab M, Faull KF, Hörkkö S, Witztum JL, et al.
Structural identification by mass spectrometry of oxidized phospholipids in
minimally oxidized low density lipoprotein that induce monocyte/endothelial
interactions and evidence for their presence in vivo. Journal of Biological
Chemistry. 1997;272:13597-607.
- Frye MA, Melton LJ, Bryant SC, Fitzpatrick LA, Wahner HW, Schwartz RS,
et al. Osteoporosis and calcification of the aorta. Bone and mineral.
1992;19:185-94.
- Boukhris R, Becker KL. Calcification of the aorta and osteoporosis: a
roentgenographic study. Jama. 1972;219:1307-11.
- Tintut Y, Parhami F, Tsingotjidou A, Tetradis S, Territo M, Demer LL. 8-
Isoprostaglandin E2 enhances receptor-activated NFκB ligand (RANKL)-
dependent osteoclastic potential of marrow hematopoietic precursors via the
cAMP pathway. Journal of Biological Chemistry. 2002;277:14221-6.
- Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms
and implications for the pathogenesis and treatment of osteoporosis 1.
Endocrine reviews. 2000;21:115-37.
- Van Lenten BJ, Wagner AC, Navab M, Fogelman AM. Oxidized
phospholipids induce changes in hepatic paraoxonase and ApoJ but not
monocyte chemoattractant protein-1 via interleukin-6. Journal of Biological
Chemistry. 2001;276:1923-9.
- Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, et
al. Atherosclerosis: basic mechanisms. Circulation. 1995;91:2488-96.