Zülal ERBAĞCI, İbrahim ERBAĞCI, Necdet A. BEKİR

Longitudinal melanonychia caused by fluconazole therapy for fungal keratitis and onychomycosis

Melanonişi striata longitudinlis veya longitudinal melanonisi (tırnakta boyuna çizgilenme), genellikle tırnak matriksindeki melanositlerin oluşturduğu pigment üreten bir odaktan kaynaklanan bir kromonisidir. Siyah ırkta ve koyu derililerde, sıklığı yasla birlikte artan normal bir varyasyon olmasına karşın beyazlarda nadir görülür. Flukonazole bağlı longitudinal pigmentasyon, daha önce sadece bir kez Hindistan 'dan koyu derili bir hastada Trikoftton nubrum'la enfekte onikomikozlu tırnakta tanımlanmıştır. Bu bildiride, fungal kertit ve onikomikoz nedeniyle uzun süreli yüksek doz oral flukonazol tedavisi gören açık tenli bir hastada flukonazolün yol açtığı diğer bir longitudinal melanonisi olgusu sunulmaktadır.

Fungal keratit ve onikomikozun flukonazolle tedavisinden kaynaklanan longitudinal melanonişi

Melanonychia striata longitudinaux or longitudinal melanonychia is a chromonychia usually caused by a pigment-producing focus of melanocytes in the nail matrix. While longitudinal melanonychia is a normal racial variation with increasing frequency in advanced age in dark-skinned persons, it is rarely seen in fair-skinned people. Fluconazole has only once been reported to produce longitudinal pigmentation on the diseased nail by Trichophyton rubrum in a dark-skinned patient from India. We report a further case offluconazole-induced longitudinal melanonychia in a fair skinned patient after long-term and high dose oral fluconazole therapy for fungal keratitis and onychomycosis.

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