Ovariektomize ve diabetik ratlarda E vitamini ve 17-B;; estradiolün lipit peroksidasyon seviyesi ile plazma lipit değerleri üzerine etkileri

Bu çalışmada, ovariektomili ve diabetli ratlarda 17-β estradiol (E2) ve E vitamininin plazma glikoz, lipit profili ve lipit peroksidasyonu üzerindeki etkileri araştırıldı. Çalışmada, 70 adet Wistar albino dişi ratlardan rastgele 7 grup oluşturuldu. Grup 1: Kontrol, Grup 2: Ovariektomi + diabet, Grup 3: Ovariektomi + diabet + E2, Grup 4: Ovariektomi + diabet + E2 + E vitamini, Grup 5: Ovariektomi, Grup 6: Ovariektomi + E2 ve Grup 7: Ovariektomi+ E2 + E vitamini olarak ayrıldı. Altmış rata ovariektomi yapıldı. Ovariektomiden on beş gün sonra, diabet oluşturmak için, ratlara 45 mg/kg tek doz streptozotosin (STZ) intraperitonal (I.P.) olarak enjekte edildi. Diabet oluşumunu takiben, E2 (40 μg/kg/gün) grup 3, 4, 6 ve 7’ye derialtı (S.C.) verildi; ilaveten E vitamini (100 mg/kg/gün) grup 4 ve 7’ye I.P. olarak olarak yirmisekiz gün süreyle verildi. Çalışmadan elde edilen verilere göre, ovariektominin etkisine bağlı olarak grup 1’e kıyasla grup 5’ te; glikoz, total kolesterol (TK), düşük dansiteli lipoprotein-kolesterol (LDL-K), çok düşük dansiteli lipoprotein-kolesterol (VLDL-K), trigliserit (TG), plazma ve eritrosit malondialdehit (MDA) seviyeleri artmış (p

Effects of vitamin E and 17 B estradiol on plasma lipid and lipid peroxidation levels in ovariectomized and diabetic rats

In this study, the effects of 17-β estradiol (E2) and vitamin E on the plasma, glucose, lipid profile and lipid peroxidation levels in ovariectomized and diabetic rats were investigated. In study, 70 female Wistar albino rats were randomly divided into 7 groups. Group 1: Control group, Group 2: Ovariectomy + diabetes, Group 3: Ovariectomy + diabetes + E2, Group 4: Ovariectomy + diabetes + E 2 + vitamin E, Group 5: Ovariectomy, Group 6: Ovariectomy + E2, and Group 7: Ovariectomy + E2 + vitamin E. Sixty of rats were ovariectomized. After fifteen days from ovariectomy, to induce diabetes, rats were injected with streptozotocin (STZ) intraperitonellly (I.P.) at dose of, 45 mg/kg body weight. Following the formation of diabetes, E2 (40 μg/kg/day) was administered subcutan (S.C.) to groups 3, 4, 6 and 7; additionally, vitamin E (100 mg/kg/day) was administered I.P. only to groups 4 and 7 for a period 28 days. According to the findings of this study,due to the effect of ovariectomy, glucose, total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C), triglyceride (TG), and plasma and erythrocyte malondialdehyde (MDA) levels were found to increased (p

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