Karaciğer fibrozisli ratlarda kuersetinin homosistein düzeyi ve koroner damar hasarı üzerine etkisi

Bu çalışma, deneysel olarak karaciğer fibrozisi oluşturulan ratların plazma homosistein düzeyi ve koroner arterlerdeki yapısal değişimleri incelemek ve bu değişimler üzerine kuersetinin etkilerini araştırmak amacıyla yapılmıştır. Bu amaçla 40 Spraque-Dawley rat 4 farklı gruba ayrıldı: 1. Grup: (Kontrol grubu, n= 10, zeytinyağı), 2. Grup: [Karbon tetraklorür (CCl4) grubu, n= 10, 0.25 mg/kg CCl4], 3. Grup: [Kuersetin grubu (K), n= 10, 150 mg/kg kuersetin], 4. Grup: [CCl4+K grubu, n= 10]. Uygulamalar 10 hafta boyunca günlük olarak ratlara gavaj yoluyla yapıldı. Plazma malondialdehit (MDA) ve homosistein düzeyleri belirlendi, karaciğer ve koroner damarlardaki patolojik değişimler incelendi. Plazma MDA (P

Effect of quercetin on homocysteine level and coronary vascular damage in rats with liver fibrosis

This study was conducted to investigate the changes in the levels of homocysteine and structure of coronary arteries in rats with experimental liver fibrosis and to investigate the effects of quercetin on these changes. For this purpose, 40 Spraque-Dawley rats were divided into 4 groups as; Group 1: (Control group, n= 10, olive oil), Group 2: [Carbon tetraclorur (CCl4) group, n= 10, 0.25 mg/kg CCl4], Group3: [Quercetine (Q) group, n= 10, 150 mg/kg quercetine], Group 4: [CCl4+Q group, n= 10]. Treatments were given by gavage to the rats daily for 10 weeks. The levels of plasma malondialdehyde (MDA) and homocysteine were determined and pathological changes in the liver and coronary arteries were examined. The levels of plasma homocysteine (P

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