Burak KARABULUT, Hatice ERÖKSÜZ, İsmet YILMAZ, Canan AKDENİZ İNCİLİ, Yesari ERÖKSÜZ, Zeynep YERLİKAYA

İki Koyunda Bakır Zehirlenmesi Kaynaklı Patolojik Değişiklikler

Yüzaltmış Akkaraman koyunu bulunan sürüden iki hayvanda bakır intoksikasyonu bildirilmiştir.Makroskobik bulgular arasında belirgin sarılık, hemoglobinürik nefroz ve belirginliği artmış hepatiklobüler yapı vardı. Histopatolojik incelemede karaciğer ve böbrekte multifokal dejeneratif venekrotik değişiklikler görüldü. İmmunohistokimyasal olarak; rodanin pozitif sitoplazmik boyama,hepatositlerde ve tübüler epitel hücrelerinde multifokal olarak tespit edildi. Hepatik ve renal bakırkonsantrasyonu ıslak dokularda 244.24 mg/1000 g ve 70.35 mg/1000 g idi. Genel olarak, veriler,böbrek hasarının hemoglobinüri ile ilişkili olduğu, hastalığın hemolitik sonrası bir fazda olduğunugöstermektedir.

Pathological Changes due to Copper Toxication in TwoSheep

Copper intoxication was reported in two animals from a herd of 160 grazing Akkaraman sheep.Gross findings included marked icterus, hemoglobinuric nephrosis and enhanced hepatic lobularpattern. Histopathological examination showed multifocal degenarative and necrotic changes inliver and kidney. Immunohistochemically; rhodanine-positive cytoplasmic staining was detectedmultifocally in hepatocytes and tubular epithelial cells. Hepatic and renal copper concentration was244.24 mg/1000 g and 70.35 mg/1000 g in wet tissues. Overall, data showed the presence ofapost-hemolytic phase of disease, in which renal damage is associated with hemoglobinuria.

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