Serkan YILDIRIM, Ömer Faruk KELEŞ, Ahmet UYAR, Zabit YENER

Holştayn bir inekte lumpy skin disease (nodüler ekzantem) olgusu

Lumpy Skin Disease (LSD) s ı ğı rlarda Capripox virus cinsi bir virüs tarafı ndan meydana getirilen, yüksekate ş ve deride multifokal nodüllerin oluş mas ı yla karakterize olan akut bulaş ı cı viral bir hastal ı ktı r.Hastal ı k, Ortadoğ u ve Afrikada endemik olarak görülmekte ve önemli ekonomik kayı plara nedenolmaktadı r. Bu olgu sunumunda Şı rnak İli Merkez mahallesinde Hol ş tayn ı rkı bir inekte karş ı laş ı lan LSDenfeksiyonunun bildirilmesi amaçland ı . Hayvan sahibi tarafı ndan 09 Mayı s 2014 tarihinde ineğ invücudunun her tarafı nda ş i ş liklerin görüldü ğ üne dair İl Gı da Tarı m ve Hayvancı l ı k Müdürlü ğ ünebaş vuruldu. Anamnezde anoreksi, süt verimi ve canl ı a ğ ı rl ı k artı ş ı nda azalma, klinik incelemede deridebirkaç cm büyüklüğ ünde multifokal nodüller, subkapsular ve prefemoral lenf yumruları nda büyümesaptandı . Bu bulgular do ğrultusunda hastal ı ğ ı n LSD olabilece ğ i dü ş ünülerek al ı nan defibrine kan örne ğ iAdana Veteriner Kontrol Enstitü Müdürlü ğ üne, deriden al ı nan nodüller ise Yüzüncü Yı l ÜniversitesiVeteriner Fakültesi Patoloji Anabilim Dal ı na gönderildi. Enstitünün Moleküler Biyoloji Laboratuvarı ndaReal Time PCR ile yap ı lan analiz sonucunda LSD pozitif oldu ğu tespit edildi. Histopatoljikal olarakepidermis ve kı l follikülü epitel hücrelerinde balonumsu dejeneasyon, akantozis, dermiste ödem,vaskülitis ve trombozlar, yang ı sal hücre infiltrasyonları ile karakterize dermatitis belirlendi. Koyun çiçe ğ ihücrelerine benzer histiyositlerin ve makrofajları n bir kı sm ı nda eozinofilik intrastoplazmik inkluzyonlargörüldü. Sonuç olarak, Hol ş tayn ı rk ı bir inekte deride görülen fokal dissemine nodüler lezyonlar ilekarakterize LSD enfeksiyonu patolojik bulguları yla ülkemizde ilk kez tan ı mlanm ı ş tı r.

A lumpy skin disease (nodular exanthem) case in A holstein cow

Lumpy Skin Disease (LSD) is an acute and contagious disease caused by a virus that belongs toCapripox virus genus and characterized by high fever and multifocal nodules on skin in cattle. LSD isendemic in Middle East and Africa causing significant economical losses. In this case report, it wasaimed to report LSD infection in a Holstein cattle which was located in the central district of Şı rnak City.On 09 May 2014, the owner of the animal reported to the Food, Agriculture and Livestock Directory ofŞı rnak about the swellings all around his animal s body. After clinical examination, multifocal nodules inseveral centimeters size on skin and subcutis were found and also in anamnesis anorexia, a decline inmilk production and live weight gain were determined. Subcapsular and prefemoral lymph nodes wererather enlarged. Related with these symptoms under the suspicion of LSD, taken defibrinate bloodsample was sent to Adana Veterinary Control Institute and nodules obtained from skin were sent toUniversity of Yüzüncü Yı l Veterinary Medicine Faculty Department of Pathology. After the analysis withthe Real Time PCR in the molecularbiology laboratory of the Institute, the blood sample were reported asLSD positive. Histopathologically, dermatitis was observed which was characterized by balloondegeneration and hyperplasia in the epithelial cells of the epidermis and hair follicles, acanthosis,multifocal necrosis in the dermis with the infiltration of inflammatory cells, vasculitis and thrombosis.Besides, scattered throughout the inflammation were variable numbers of "sheep pox cells" histiocyte-likecells with large vacuolated nuclei and eosinophilic intracytoplasmic inclusion bodies.As a result, it is the first time in our country that an LSD infection was diagnosed which was characterizedby focal disseminate nodular lesions on the skin and subcutis of a Holstein cattle with its macroscopicand microscopic findings.

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