Burak KARABULUT, Aydın ÇEVİK, Murat TANRISEVER

Golden Retriever Irkı Bir Köpekte Kötü Prognozlu Fibrosarkoma Olgusu

On yaşlı, erkek, Golden Retriever ırkı köpek, sol pelvik bölgede şişlik şikayetiyle cerrahi kliniğine getirildi. Sol-üst pelvis bölgesindeki tümör şüpheli kitle bütün olarak alındı. Kitlenin 1570 g ağırlığında ve 20x15x7 cm boyutlarında olduğu görüldü. Histopatolojik incelemede kitlenin fibrosarkoma olduğu tespit edildi. Kitlenin alınmasından 1 hafta sonra, haftada 3 doz vinkristin ile kemoterapiye başlandı. Aynı bölgede, tedaviden 2 hafta sonra tümörün tekrardan büyümeye başladığı görüldü. Yaklaşık 4 hafta sonra 2. cerrahi operasyon yapıldı, ancak hayvan operasyondan 8 saat sonra öldü. Bu vaka takdiminde, tümör cerrahisine ve kemoterapik tedaviye yanıt vermeyen kötü prognozlu bir fibrosarkoma olgusu sunulmuştur.

A Fibrosarcoma Case with Poor Prognosis in a Golden Retriever Breed Dog

A ten-year-old male, Golden Retriever breed dog was brought to the surgical clinic with a sign ofswelling in the left pelvic region. The tumor suspected mass, located in the upper left of the pelvis,was totally excised. The mass of the tumor was approximately 1570 g and the size was 20x15x7cm. Histopathological examination of the tumor revealed fibrosarcoma. Chemotherapy was initiated1 week after the operation by using of vincristine sulphate 3 times per week. Recurrence startedagain in the same region about two weeks after the last chemotherapy. Approximately 4 weekslater, the second surgical operation was performed because the mass grow up again. Patient died8 hours after the last operation. In this case report, a case of fibrosarcoma with poor prognosis thatdid not respond to tumor surgery and chemotherapeutic treatment is presented.

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1. Atalan G, Atasever A, Yavuz Ü, Güneş V, Onmaz AC. Kangal Irkı bir köpekte oral fibrosarkom olgusu. FÜ Sağ Bil Vet Derg 2009; 23: 167-169.
2. Palmer N. Bones and Joint. In: Jubb KVF, Kennedy PC, Palmer N. (Editors ). Pathology of Domestic Animals. Vol. 1, 4th Edition, London: Academic Press Inc 1993: 125- 138.
3. Stannard AA, Pulley LT. Tumors of the skin and soft tissues. In: Moulton JE (Editor). Tumors in Domestic Animals. 2nd Edition, Berkeley: University of California Press 1978: 21 .
4. Walder EJ, Gross TL. Neoplastic Diseases of the Skin. Part VI. Fibrocytic Tumors. In: Gross TL, Ihrke PJ, Walker EJ. (Editors). Veterinary Dermapathology. St Louis: Mosby Year Book 1992: 407-418.
5. Ciekot PA, Powers BE, Withrow SJ, et al. Histologically lowgrade, yet biologically high-grade, fibrosarcomas of the mandible and maxilla in dogs: 25 cases (1982-1991). J Am Vet Med Assoc 1994; 204: 610-615.
6. Wallace J, Matthiesen DT, Patnaik AK Hemimaxillectomy for the treatment of oral tumors in 69 dogs. Vet Surg 1992; 21: 337-341.
7. Maliki O, Aleksandrov O, Carler P, et al. Fibrosarcoma of the nasal cavity: A case report. EJENTAS 2014; 15: 275- 277.
8. Goldschmidt MH, Hendrick MJ. Tumors of the skin and soft tissues. In: Meuten DJ (Editor). Tumors in Domestic Animals. 4th Edition, Iowa: Iowa State University Press 2003: 45–117.
9. Avcı H, Yaygıngül R, Gültekin M, et al. Primary intestinal fibrosarcoma caused by intestinal perforation in a dog: A case report. Vet Med Czech 2012; 57: 314-319.
10. Kuntz CA, Dernell WS, Powers BE, et al. Prognostic factors for surgical treatment of soft-tissue sarcomas in dogs: 75 cases (1986–1996). J Am Vet Med Assoc 1997; 211:1147-1151.
11. Bostock DE, Dye MT. Prognosis after surgical excision of canine fibrous connective tissue sarcomas. Vet Pathol 1980; 17: 581 -588.
12. Moore AS. Recent advances in chemotherapy for nonlymphoid malignant neoplasms. Compend Cont Educ Pract Vet 1993; 15: 1039-1050.
13. Ogilvie GK, Obradovich JE, Elmslie RE, et al. Efficacy of mitoxantrone against various neoplasms in dogs. J Am Vet Med Assoc 1991; 198: 1618-1621.
14. McChesney SL, Withrow SJ, Gillette EL, et al. Radiotherapy of soft tissue sarcomas in dogs. J Am Vet Med Assoc 1989; 194: 60-63.
15. Forrest LJ, Chun R, Adams WM, Cooley AJ, Vail DM. Postoperative Radiotherapy for Canine Soft Tissue Sarcoma. J Vet Intern Med 2000; 14: 578-582.
16. Pirkey-Ehrhart N, Withrow SJ, Straw RC, et al. Primary rib tumors in 54 dogs. J Am Anim Hosp Assoc 1995; 31: 65- 69.
17. Gardner H, Fidel J, Haldorson G, Dernell W, Wheeler B. Canine oral fibrosarcomas: A retrospective analysis of 65 cases (1998–2010). Vet Comp Oncol 2013; 1: 40-47.
18. Martano M, Iussich S, Morello E, Buracco P. Canine oral fibrosarcoma: Changes in prognosis over the last 30 years? Vet J 2018; 241: 1 -7.
19. Atalay Vural S, Şahal M, Aydın Y. Bir köpekte ağızda fibrosarkom ve testislerde seminom olguları. AÜ Vet Fak Derg 1994; 41: 351 -355.
20. Seyrek İntaş D, Rau FC, Michele U, Gerwing M, Kramer M. Köpeklerde Aksillar Bölgede Rastlanan Yumuşak Doku Kitlelerinin Tanısında Ultrasonografinin Önemi. Türkiye Klinikleri J Vet Sci 2014; 5: 91 -96.
21. Bozkurt MF. Bir köpekte vaginal fibrosarkoma. Kocatepe Vet J 2013; 6: 83-86.
22. Ettinger SN. Principles of Treatment for Soft-Tissue Sarcomas in the Dog. Clin Tech in Small Anim Pract 2003; 18: 118-122.