Osman İBİŞ, Hamit USLU, Hüseyin Avni EROĞLU, Gözde ATİLA, Ebru BEYTUT, Yusuf ERSAN, Evren KOÇ

Effects of oral Administered Panax ginseng and Panax ginseng + Ganoderma lucidum extracts on oxidative stress, lipid profile and liver protein expressions hamsters

Bu çal ı ş ma antioksidan özelliklerinden dolay ı yayg ı n olarak kullan ı lan Panax ginseng ve Panaxginseng + Ganoderma lucidum eksraktları n ı n sa ğ l ı kl ı hamsterlerin plazma, eritrosit, karaci ğ er,böbrek ve kalp total oksidan (TOS), total antioksidan seviyeleri (TAS) ile plazma lipit profili vekaraci ğer serum proteinlerindeki de ğ i ş iklikleri belirlemek amac ı yla yap ı ld ı . Deneysel gruplar Kontrol(K, normal içme suyu), Panax ginseng (G, 100 mg/kg/gün) ve Panax ginseng + Ganodermalucidum (G+GL, 140 mg/kg/gün Panax ginseng + 140 mg/kg/gün Ganoderma lucidum) olarakbelirlendi. Deney ve kontrol grubundaki hayvanlara 60 gün süreyle içme suyu ş eklinde uygulamayap ı ld ı . Biyokimyasal analizler neticesinde lipit profili üzerinde önemli bir de ğ i ş iklik gözlenmedi(P>0.05). Yine plazma, eritrosit, karaci ğ er ve böbrek TAS ile karaci ğ er, böbrek ve kalp dokuları n ı nTOS düzeylerinde bir de ğ i ş iklik olmazken; gerek Panax ginseng gerekse Panax ginseng +Ganoderma lucidum eksraktları n ı n plazma TOS düzeylerini önemli düzeyde azalttı ğ ı belirlendi(P

Oral olarak verilen Panax ginseng ve Panax ginseng + Ganoderma lucidum ekstraktların ın hamsterlardaki oksidatif stres, lipit profili ve karaciğer protein ekspresyonları üzerine etkileri

This study has been conducted with the purpose of determining the changes caused by Panaxginseng and Panax ginseng + Ganoderma lucidum extracts, commonly used for their antioxidantproperties, in the plasma, erythrocyte, liver, kidney and heart total oxidant statuses (TOS), totalantioxidant statuses (TAS), plasma lipid profiles and liver serum proteins of healthy hamsters.Experimental groups were determined as Control (normal drinking water), Panax ginseng (100mg/kg/day) and Panax ginseng + Ganoderma lucidum (140 mg/kg/day Panax ginseng + 140mg/kg/day Ganoderma lucidum). Applications of drinking water were carried out on animals servingas experimental and control groups for 60 days. As a result of the biochemical analyses, nosignificant change in the lipid profile was observed (P>0.05). While there were no changes in theTAS rates of plasma, erythrocyte, liver and kidney tissues as well as TOS rates of liver, kidney andheart tissues; it was determined that both Panax ginseng and Panax ginseng + Ganodermalucidum extracts reduce TOS rates of plasma (P

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