Ratlarda homosisteinin oksidan ve antioksidan sistem ile koroner damarlarda oluşturduğu değişiklikler üzerine E Vitaminin etkisi

Bu çalışma, uzun süreli homosistein uygulanan ratlarda antioksidan enzim düzeylerini ve koroner arterlerin yapısındaki değişimleri ve bu değişimlere E vitamininin etkilerini araştırmak için yapılmıştır. Bu amaçla 30 dişi ve 30 erkek, toplam 60 Wistar albino rat kullanıldı. Hayvanlar rast gele 3 gruba ayrıldı. Bu gruplar kontrol, homosistein ve Vit-E olarak isimlendirildi. Altı hafta boyunca her gün kontrol grubuna serum fizyolojik, homosistein grubuna 0.71 mg/kg homosistein, Vit-E grubuna da 0.71 mg/kg homosistein + 125 mg/kg dl- $alpha$ tokoferol asetat periton içi olarak uygulandı. Plazma homosistein, Malondialdehit (MDA) ve doku MDA düzeyleri kontrol grubuyla karşılaştırıldığında homosistein grubunda önemli derecede artma (P

Effect of vitamin E on homocysteine-induced changes in oxidant, antioxidant system and coronary artery in rats

This study was conducted to investigate the changes in the levels of antioxidant enzyme and structure of coronary arteries in long-term homocysteine administired rats and to investigate the effects of vitamin E on these changes. For this purpose, 30 male and 30 female Wistar albino rats were used. The rats were randomly divided into 3 groups. These groups were named as control, homocysteine and vit-E. Normal saline was intraperitoneally administered to the control group; dl-homocysteine (0.71 mg/kg) was intraperitoneally administered to the homocysteine group; dl-homocysteine (0.71 mg/kg) + dl- $alpha$ tocopheryl acetate (125 mg/kg) were intraperitoneally administered to the vit-E group daily for 6 weeks. Compared to the control group, levels of plasma homocysteine, MDA and tissue MDA significantly (P

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