Bülent ELİTOK, Mustafa KABU, Özgül Mukaddes ELİTOK

Evaluation of liver function tests in cows during periparturient period

Doğum Öncesi ve Doğum Sonrası Dönemdeki İneklerde Karaciğer Fonksiyon Testlerinin Değerlendirilmesi Bu çalışmanın amacı süt ineklerinde periparturient dönemde (doğum önceki 1 hafta ile doğumdan sonraki 3 haftalık periyod) karaciğerde meydana gelen metabolik değişiklikleri saptamak amacıyla yapıldı. Bu çalışma periparturient dönemde bulunan 21 baş Holstein inek (çalışma grubunu) ve kuru dönemde bulunan 8 inekte (kontrol grubu) yapıldı. Bütün hayvanlar doğum öncesi 1. hafta, doğum günü (0. gün) ve doğumdan sonraki 1, 2 ve 3. haftalarda bromosulphthalein (BSP) clearence test, karaciğer biyopsisi ve metabolik profil yönünden gözlendi. Ölçüm yapılan tüm zamanlarda intravenöz olarak tek doz BSP verilerek, plazma BSP konsantrasyonlarında^ değişiklikler belirlendi. Ayrıca çalışma süresince ölçüm yapılan her zamana ait metabolik profil de saptandı. Analizleri yapılan değişkenlerdeki en dikkat çekici değişikliklerin diğer gruplar (p

Doğum öncesi ve doğum sonrası dönemdeki ineklerde karaciğer fonksiyon testlerinin değerlendirilmesi

The objective of the study was to determine various liver metabolic changes associated with periparturient period (1 week before calving and 3 weeks after parturition) in dairy cows. Twenty-one Holstein study cows and eight control from one commercial herd were used all the animals were monitored for bromosulphthalein (BSP) clearence test, liver biopsy and metabolic profile at 1st week before calving, on calving day (day 0), and at 1st, 2nd and 3rd weeks after parturition. Single intravenous injections of BSP were given to cows and the change in plasma BSP concentration with time was analysed for each measurement point. Additionally, metabolic profile as determined at each time during the study. Analyses of variant indicated that most dramatic changes especially occured at wk 1 before parturition prior to wk 2 after parturition when compared to the other study groups (p

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1. Curtis CR, Erb H, Sniffen C, et al. Association of periparturient hypocalcemia with eight periparturient disorders in Holstein cows. J Am Vet Med Assoc 1983; 5: 559.
2. Goff JP and Horst RL. Physiological Changes at Parturition and Their Relationship to Metabolic Disorders. J Dairy Sci 1997; 80: 1260-1268.
3. Grummer RR. Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. J Anim Sci 1995; 73: 2820.
4. Cornelius CE. Liver function. In: Kaneko JK, ed. Clinical biochemistry of domestic animals. 3 rd ed. New york: Academic Press Inc, 1980; 201-258.
5. Reynolds, CK, Aikman PC, Lupoli B, et al. Splanchnic metabolism of dairy cows during the transition fromlate gestation through early lactation. J Dairy Sci 2003; 86: 1201-1217.
6. Mikner JP, Robertson WG. Brom sulphalein fractionel clearence in dairy cattle as a criterion of liver function and the simultaneous determinetion of volumes of plsama and blood. J Dairy Sci 1957; 40:914-921.
7. Reid IM, Collins RA The pathology of post-parturient fatty liver in high-yielding dairy cows. Invest Cell Pathol 1980; 3(3): 237-49.
8. Craig AM, Pearson EG, Meyer C, et al. Serum liver enzyme and histopathologic changes in calves with chronic and chronic-delayed Senecio jacobea toxicosis. Am J Vet Res 1991; 52: 1969.
9. Herdt TH. Variability characteristics and test selection in herd-level nutritional and metabolic profile testing. Vet Clin N Am Food Anim Pract 2000; 16: 387-403.
10. Van Saun RJ. Peripartum nutrition: The key to diagnosis and management of periparturient disease. Proc Am Assoc Bovine Pract 1997; 33-42.
11. Zhu LH, Armentano, LE, Bremmer DR, et al. Plasma concentration of urea, ammonia, glutamine around calving, and relation of hepatic triglyceride, to plasma ammonia removal and blood acid-base balance. J Dairy Sci 2000; 83: 734-740.
12. Collins RA, Reid IM, Williams LA, et al. Histological measurement of fat content of liver of dairy cows. J Comp Pathol 1985; 95(3): 437-41.
13. Sevine M, Basoglu A, Birdane FM. Liver function in dairy cows with fatty liver. Rev Med Vet 2001; 152: 297-300.
14. Pearson EG, Dirksen G, Meyer J, et al. Evaluation of liver function tests in neonatal calves. J Am Vet Med Assoc 1995; 1; 207 (11): 1466-9.
15. Reid I, Robert J. Fatty liver in dairy cows. In Practice 1982;164-180.
16. Bertics JS, Grummer RR, Cadorniga-Valino C, et al. Effect of prepartum dry matter intake on liver triglyceride concentration and early lactation. J Dairy Sci 1992; 75:1914.
17. Skaar TC, Grummer RR, Dentine MR, et al. Seasonal effects of prepartum and postpartum fat and niacin feding on lactatio performance and lipid metabolism. J Dairy Sci 1989; 75: 184.
18. Studer VA, Grummer RR, Bertics SJ. Effect of prepartum propylene glycol administartion periparturient fatty liver in dairy cows. J Dairy Sci 1992; 75: 184.