Obezite ve Kas-İskelet Sistemi

Obezite ve ilişkili metabolik hastalıklar, her geçen gün sıklığı artan, önemli halk sağlığı problemleridir. Obezite kas-iskelet sitemini etkilemekte ve çeşitli enflamatuar ve non-enflamatuar romatizmal hastalıkların sıklığını ve şiddetini artırmaktadır. Ek olarak, eşlik eden obezite romatizmal hastalık-larının tedavisinde beklenilen tedavi yanıtını azaltabilmektedir. Tersine, bir kısım enflamatuar romatizmal hastalıklar ve bu hastalıkların tedavilerinde kullanılan ilaçlar obezite ve ilişkili metabolik hastalıkların riskini artırmaktadır.

Obesity and Musculoskleteal System

Obesity and related metabolic disorders are important public health problems with gradually increasing prevalences. Obesity affects musculoskeletal system. It increases the frequency and severity of several inflammatory and non-inflammatory rheumatic diseases. Moreover, comorbid obesity may decrease the anticipated responses to treatment by rheumatic diseases. On the other hand, some of inflammatory rheumatic diseases and their thera-peutic agents may increase the frequencies of obesity and related metabolic diseases

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  • Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 2010; 375: 132-40.
  • Bouchard C. BMI, fat mass, abdominal adipo-sity and visceral fat: where is the 'beef'? Int J Obes 2007; 31: 1552-3.
  • Sellam J, Berenbaum F. Osteoarthritis and obe-sity. Rev Prat 2012; 62: 621-4.
  • Altman RD, Hochberg MC, Moskowitz RW, et al. Recommendations for the medical manage-ment of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000; 43: 1905-15.
  • Zhang W, Doherty M, Arden N, et al. EULAR evidence based recommendations for the mana-gement of hip osteoarthritis: report of a task for-ce of the EULAR Standing Committee for In-ternational Clinical Studies Including Therapeu-tics (ESCISIT). Ann Rheum Dis 2005; 64: 669-81.
  • Anderson JJ, Felson DT. Factors associated with osteoarthritis of the knee in the first natio-nal Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am J Epidemiol 1988; 128: 179-89.
  • Collins JE, Donnell-Fink LA, Yang HY, et al. Effect of obesity on pain and functional reco-very following total knee arthroplasty. J Bone Joint Surg Am. 2017; 99: 1812-8.
  • Grotle M, Hagen KB, Natvig B, Dahl FA, Kvien TK. Obesity and osteoarthritis in knee, hip and/or hand: An epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord 2008; 9: 132.
  • Kiadaliri AA, Lohmander LS, Moradi-Lakeh M, et al. High and rising burden of hip and knee os-teoarthritis in the Nordic region, 1990-2015. Acta Orthop 2018; 89: 177-83.
  • Evans AL, Paggiosi MA, Eastell R, et al. Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood. J Bone Miner Res 2015; 30: 920-8.
  • Reid IR, Ames RW, Evans MC, et al. Determi-nants of the rate of bone loss in normal postme-nopausal women. J Clin Endocrinol Metab 1994; 79: 950-4.
  • Prieto-Alhambra D, Premaor MO, Fina Aviles F, et al. The association between fracture and obesity is site-dependent: a population-based study in postmenopausal women. J Bone Miner Res 2012; 27: 294-300.
  • Compston JE, Watts NB, Chapurlat R, et al. Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med 2011; 124: 1043-50.
  • Teichtahl AJ, Urquhart DM, Wang Y, et al. Physical inactivity is associated with narrower lumbar intervertebral discs, high fat content of paraspinal muscles and low back pain and disa-bility. Arthritis Res Ther 2015; 17: 114.
  • Dario AB, Ferreira ML, Refshauge K, et al. Are obesity and body fat distribution associated with low back pain in women? A population-based study of 1128 Spanish twins. Eur Spine J 2016; 25: 1188-95.
  • Ibrahimi-Kaçuri D, Murtezani A, Rrecaj S, et al. Low back pain and obesity. Med Arch 2015; 69: 114-6.
  • Sharma A. The role of adipokines in interver-tebral disc degeneration. Med Sci (Basel) 2018; 6: E34.
  • Hauner H. Secretory factors from human adipo-se tissue and their functional role. Proc Nutr Soc 2005; 64: 163-9.
  • Van der Meer JW, Netea MG. A salty taste to autoimmunity. N Engl J Med 2013; 368: 2520-1.
  • Lu B, Hiraki LT, Sparks JA, et al. Being overweight or obese and risk of developing rhe-umatoid arthritis among women: a prospective cohort study. Ann Rheum Dis 2014; 73: 1914-22.
  • Stavropoulos-Kalinoglou A, Metsios GS, Kou-tedakis Y, et al. Redefining overweight and obe-sity in rheumatoid arthritis patients. Ann Rheum Dis 2007; 66: 1316-21.
  • Katz PP, Yazdany J, Trupin L, et al. Sex diffe-rences in assessment of obesity in rheumatoid arthritis. Arthritis Care Res 2013; 65: 62-70.
  • Jhun JY, Yoon BY, Park MK, et al. Obesity aggravates the joint inflammation in a collagen-induced arthritis model through deviation to Th17 differentiation. Exp Mol Med 2012; 44: 424-31.
  • Ajeganova S, Andersson ML, Hafström I; BARFOT Study Group. Association of obesity with worse disease severity in rheumatoid arth-ritis as well as with comorbidities: a long-term followup from disease onset. Arthritis Care Res 2013; 65: 78-87.
  • Stavropoulos-Kalinoglou A, Metsios GS, Pano-ulas VF, et al. Underweight and obese states both associate with worse disease activity and physical function in patients with established rheumatoid arthritis. Clin Rheumatol 2009; 28: 439-44.
  • Jawaheer D, Olsen J, Lahiff M, et al. Gender, body mass index and rheumatoid arthritis disea-se activity: results from the QUEST-RA Study. Clin Exp Rheumatol 2010; 28: 454-61.
  • Hassan MK, Joshi AV, Madhavan SS, Amonkar MM. Obesity and health-related quality of life: a cross-sectional analysis of the US population. Int J Obes Relat Metab Disord 2003; 27: 1227-32.
  • Klaasen R, Wijbrandts CA, Gerlag DM, et al. Body mass index and clinical response to inf-liximab in rheumatoid arthritis. Arthritis Rheum 2011; 63: 359-64.
  • Gremese E, Ferraccioli G. The metabolic synd-rome: the crossroads between rheumatoid arthri-tis and cardiovascular risk. Autoimmun Rev 2011; 10: 582-9.
  • Sandberg ME, Bengtsson C, Kallberg H, et al. Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis. Ann Rheum Dis 2014; 73: 2029-33.
  • Ottaviani S, Allanore Y, Tubach F, et al. Body mass index influences the response to inf-liximab in ankylosing spondylitis. Arthritis Res Ther 2012; 14: R115.
  • Gremese E, Bernardi S, Bonazza S, et al. Body weight, gender and response to TNF-α blockers in axial spondyloarthritis. Rheumatology 2014; 53: 875-81.
  • Armstrong AW, Harskamp CT, Armstrong EJ. The association between psoriasis and obesity: a systematic review and meta-analysis of observa-tional studies. Nutr Diabetes 2012; 2: 54.
  • Bhole VM, Choi HK, Burns LC, et al. Differen-ces in body mass index among individuals with PsA, psoriasis, RA and the general population. Rheumatology 2012; 51: 552-6.
  • Love TJ, Zhu Y, Zhang Y, et al. Obesity and the risk of psoriatic arthritis: a population-based study. Ann Rheum Dis 2012; 71: 1273-7.
  • di Minno MN, Peluso R, Iervolino S, et al. Obe-sity and the prediction of minimal disease acti-vity: a prospective study in psoriatic arthritis. Arthritis Care Res 2013; 65: 141-7.
  • Eder L, Thavaneswaran A, Chandran V, et al. Obesity is associated with a lower probability of achieving sustained minimal disease activity state among patients with psoriatic arthritis. Ann Rheum Dis 2015; 74: 813-7.
  • Oeser A, Chung CP, Asanuma Y, et al. Obesity is an independent contributor to functional ca-pacity and inflammation in systemic lupus eryt-hematosus. Arthritis Rheum 2005; 52: 3651-9.
  • Lozovoy MA, Simao AN, Hohmann MS, et al. Inflammatory biomarkers and oxidative stress measurements in patients with systemic lupus erythematosus with or without metabolic synd-rome. Lupus 2011; 20: 1356-64.
  • Chaiamnuay S, Bertoli AM, Roseman JM, et al. African-American and Hispanic ethnicities, re-nal involvement and obesity predispose to hy-pertension in systemic lupus erythematosus: re-sults from LUMINA, a multiethnic cohort (LUMINAXLV). Ann Rheum Dis 2007; 66: 618-22.
  • Marighela TF, Genaro Pde S, Pinheiro MM, et al. Risk factors for body composition abnorma-lities in systemic sclerosis. Clin Rheumatol 2013; 32: 1037-44.
  • Assassi S, Del Junco D, Sutter K, et al. Clinical and genetic factors predictive of mortality in early systemic sclerosis. Arthritis Rheum 2009; 61: 1403-11.
  • Cornec D, Jamin C, Pers JO. Sjögren's syndro-me: where do we stand, and where shall we go? J Autoimmun 2014; 51: 109-14.
  • Cotrim FP, Ribaric I, Mantovani E, et al. Dysli-pidemia in adult dermatomyositis and polymyo-sitisis not associated with anti-lipoprotein lipa-se. Austin J Musculoskelet Disord 2015; 2: 1026.
  • Silva MG, Borba EF, Mello SB, et al. Serum adipocytokine profile and metabolic syndrome in young adult female dermatomyositis patients. Clinics 2016; 71: 709-14.
  • Beyl RN Jr, Hughes L, Morgan S. Update on importance of diet in gout. Am J Med 2016; 129: 1153-8.
  • Lee J, Lee JY, Lee JH, et al. Visceral fat obesity is highly associated with primary gout in a me-tabolically obese but normal weighted popula-tion: a case control study. Arthritis Res Ther 2015; 17: 79.
  • Zhen H, Gui F. The role of hyperuricemia on vascular endothelium dysfunction. Biomed Rep 2017; 7: 325-30.