Editöre Mektup: Ortalama Trombosit Hacmi Yeni Tanı Konulmuş Hipertansif Hastalarda Arteriyel Sertlik İçin Yararlı Bir Belirteç Olmayabilir

ÖZET Günümüzde, türbidimetrik trombosit agregasyonu trombosit fonksiyonlarının değerlendirilmesinde altın standart testtir ve ortalama trombosit hacmi (OTH) dahil olmak üzere trombosit parametrelerinin türbidimetrik trombosit agregasyonu sonuçları ile korelasyonu yoktur. Keza, OTH ölçümü standardizasyon problemleri nedeni ile tam olarak uygulanamaz. OTH antikoagüle edilmiş numunelerde zamanla giderek artış gösterir. OTH tayininde sitrat ile en uygun ölçüm zamanı kanın alınmasından 60 dakika sonradır. OTH ölçümüne dair başka bir önemli problem farklı teknolojilerin %40a kadar varan farklı sonuçlar verebilmesidir. Sonuç olarak, OTH yeni tanı konulmuş hipertansif hastalarda arteriyel sertlik için yararlı bir belirteç olmayabilir.

Mean platelet volume may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients

Mean platelet volume may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients Nowadays, turbidimetric platelet aggregation is the gold standard test for evaluation of platelet function, and platelet indices including mean platelet volume (MPV) were not correlated with the results of turbidimetric platelet aggregation. Also, measurement of MPV cannot be performed completely because of standardization problems. MPV progressively increases with time in anticoagulated samples. Optimal measurement time with citrate should be 60 minutes after venipuncture in the determination of MPV. Another important problem regarding MPV measurement is that different technologies reveal different results up to 40%. As a result, MPV may not be a useful predictor for arterial stiffness in newly diagnosed hypertensive patients.

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