Hüseyin AKSOY, Gülsüm UYSAL, Eda Ülkü KARAKILIÇ, Fulya ÇAĞLI, Gökhan AÇMAZ, Hatice AKKAYA

Hematolojik Parametrelerin Missed Abortus Tanısına Etkileri

Amaç: Missed Abortus (MA) kapalı bir serviksle maternal-fetal yapılara ait ölü dokuların günler, haftalar hatta aylarca uterin kavite içinde kalmasıdır. Fetal ölüm ve abortusun tanısı temelde klinik ve ultrason yardımı ile konulur. Gelişmiş ultrason görüntü teknikleri sonrasında MA daha sık görülmeye başlamıştır. Sağlıklı bir gebeliğin devamı ya da tespiti hakkında henüz güvenilir bir biyokimyasal marker yoktur ve etyolojisi hala net değildir. Yeni çıkan çalışmalarda bazı hematolojik parametreler ile tekrarlayan gebelik kayıpları arasında ilişki bulunmuştur. Bu çalışmada amacımız hematolojik parametrelerin MA tanısına etkisini araştırmaktır. İkincil amacımız serum Ca 125 düzeylerinin missed abortus tanısındaki rolünü değerlendirmektir. Yöntemler: Bu çalışmaya 90’nı missed abortus, 143’ü sağlıklı kontrol olmak üzere toplamda 233 gebe dahil edilmiştir. Bu hastaların rutin hematolojik parametrelerindeki hemoglobin, beyaz küre, nötrofil, lenfosit, ortalama korpuskular hacim (MCV), ortalama platelet hacmi (MPV), eritrosit dağılım genişliği (RDW) değerleri kaydedilmiştir. Ayrıca tüm hastaların serum Ca 125 değeri de bakılıp not edilmiştir. Bulgular: MA grubunda lenfosit, platelet ve RDW anlamlı olarak yüksek bulunmuştur. (sırasıyla; p=0,03, p=0,003, p=0,005) Gruplar arasında anlamlı çıkan bu değerler multivaryant analizde tekrar bakıldığında MA tanısında RDW’nin bağımsız faktör olduğu görülmüştür (OR: 0,810, p

The Efficacy of Haematologic Parameters in the Diagnosis of Missed Abortus

Objective: The aim of the present study was to investigate the efficacy of hematologic parameters in diagnosing missed abortus(MA). Our second aim was to elucidate the diagnostic value of maternal serum cancer antigen 125 (CA 125) levels in missed abortion.Methods: Hemoglobin, white blood cell, neutrophil, lymphocyte, and platelet levels; mean corpuscular volume; mean plateletvolume (MPV); and red cell distribution width (RDW) in complete blood count samples were obtained from all patients diagnosedwith MA (group 1; n=90) and from women with healthy pregnancies (group 2; n=143).Results: Lymphocyte, platelet, and RDW variables were significantly higher in group 1 (p=0.03, p=0.003, and p=0.005, respectively).High RDW value was independent predictors of MA (OR: 0.810, p

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