Buğra Tolga KONDUK, Abdullah Emre YILDIRIM, Ayhan BALKAN, Sezgin BARUTÇU, Şeniz DEMİRYÜREK, Yeşim GÜRBÜZ, Ramazan Erdem ER, Ömer ŞENTÜRK

Dispepsisi Olan Hastalarda Helicobacter pylori Enfeksiyonunun Duodenit Üzerine Etkisi

Amaç: Helicobacter pylori (H. pylori) infeksiyonu, birçok gastroduodenal hastalığın başlıca nedenlerinden biridir, fakat duodenit oluşumundaki rolü tam olarak bilinmemektedir. Bu çalışmanın amacı, dispepsili hastalarda duodenitin klinik, laboratuar ve endoskopik özellikleri üzerine gastrik H. pylori infeksiyonunun rolünü araştırmaktı. Yöntemler: Bu çalışmaya toplamda 131 hasta (77 kadın ve 54 erkek) dahil edildi. Kontrol grubu H. pylori-negatif dispepsi hastalarından oluşturuldu (n=60). Bütün hastalarda klinik, biyokimyasal ve endoskopik değerlendirmeler yapıldı. H. pylori’yi saptamak ve histopatolojik değerlendirmeler için gastrik antrum, korpus ve duodenal bulbusdan biyopsiler alındı. Bulgular: H. pylori infeksiyonu 71 hastada pozitifti (%54,2). Ülser benzeri dispepsiyi 87 hastada (%66,4) ve dismotilite benzeri dispepsiyi 44 hastada tespit ettik (%33,6). Gruplar arasında biyokimyasal parametrelerde anlamlı farklılıklar yoktu. Fakat, H. pylori-pozitif grupta ferritin düzeylerinde anlamlı azalma vardı (p=0,001). Endoskopik muayenede H. pylori-pozitif grupta daha sık erozif duodenit gözlendi (p=0,039). H. pylori-pozitif grupta histopatolojik özellik olarak villus obliterasyonu ve duodenal intraepiteliyal lenfositoz daha çok gözlendi (her iki grup için p

Effect of Helicobacter pylori Infection on Duodenitis in Patients with Dyspepsia

Objective: Helicobacter pylori (H. pylori) infection is one of the principal causes of many gastroduodenal diseases, but its role induodenitis development is not exactly known. The purpose of this study was to elucidate the role of gastric H. pylori infection onclinical, laboratory, and endoscopical features of duodenitis in patients with dyspepsia.Methods: A total number of 131 patients (77 females and 54 males) were enrolled in the study. The control group was formed fromH. pylori-negative dyspepsia patients (n=60). Clinical, biochemical, and endoscopical evaluations were performed on all subjects.Biopsies were obtained from the gastric antrum, corpus, and duodenal bulb to detect H. pylori and for histopathological assessments.Results: H. pylori infection was positive in 71 patients (54.2%). We detected ulcer-like dyspepsia in 87 patients (66.4%) and dysmotility-likedyspepsia in 44 patients (33.6%). There were no marked differences in biochemical parameters between the groups. On theother hand, there was a marked decrease in ferritin levels in H. pylori-positive group (p=0.001). Endoscopical examination showed thatthe H. pylori-positive group had more frequent erosive duodenitis (p=0.039). Villous obliteration and duodenal intraepithelial lymphocytosisas histopathological features were seen more commonly in the H. pylori-positive group (p

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