Surgical Treatment in Small Cell Lung Cancer: Delayed Evaluation?

Surgical Treatment in Small Cell Lung Cancer: Delayed Evaluation?

Lung cancers are the most common solid organ cancers and are responsible for a major part of cancer deaths. They account for1/3 or 1/4 of all deaths from cancer. Small cell lung cancers (SCLC) are known for having very poor outcomes in survival analyses,despite multiple treatment applications. Even though the traditional literature claims that treatment of this disease is essentiallymedical, surgical experiences do not confirm such claim. In this study, we examined whether small cell lung cancer is a non-surgicaldisease as it is believed to be. The medical literature in the thoracic and cardiovascular surgery and oncology network wasreviewed, and studies, cases, and meta-analysis articles that provided small cell lung cancer treatment outcomes were examined.A discussion was made by also analyzing the survival data in the light of the available guidelines. It is seen that treatment of smallcell lung cancer is not mainly medical and that the surgical option can be administered similarly to non-small cell lung cancer(NSCLC). Unfortunately, even the targeted treatment options do not provide recovery at a satisfactory level in the current state ofcancer treatment. Surgery option keeps it validity as the most important weapon against all stages and cell types in lung cancer.

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  • (ACS) ACS. Cancer Facts and Figures 2016 [Available from: https:// www.cancer.org/cancer/small-cell-lung-cancer/detection-diagnosis-staging/survival-rates.html.
  • Goldstein SD, Yang SC. Role of surgery in small cell lung cancer. Surg Oncol Clin N Am 2011; 20: 769-77. [CrossRef]
  • Shepherd FA, Ginsberg R, Patterson GA, Feld R, Goss PE, Pearson FG, et al. Is there ever a role for salvage operations in limited small-cell lung cancer? J Thorac Cardiovasc Surg 1991; 101: 196-200.
  • Network NCC. Small Cell Lung Cancer 2017 [Available from: https:// www.nccn.org/professionals/physician_gls/pdf/sclc.pdf.
  • Haddadin S, Perry MC. History of small-cell lung cancer. Clin Lung Cancer. 2011; 12: 87-93. [CrossRef]
  • Deslauriers J. Surgery for small cell lung cancer. Lung Cancer 1997; 17: 91-8. [CrossRef]
  • Comparative trial of surgery and radiotherapy for the primary treatment of small-celled or oat-celled carcinoma of the bronchus. First report to the Medical Research Council by the working-party on the evaluation of different methods of therapy in carcinoma of the bronchus. Lancet 1966; 2: 979-86.
  • Miller AB, Fox W, Tall R. Five-year follow-up of the Medical Research Council comparative trial of surgery and radiotherapy for the primary treatment of small-celled or oat-celled carcinoma of the bronchus. Lancet 1969; 2: 501-5.[CrossRef]
  • Fox W, Scadding JG. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus. Ten-year follow-up. Lancet. 1973; 2: 63-5. [CrossRef]
  • Lennox SC, Flavell G, Pollock DJ, Thompson VC, Wilkins JL. Results of resection for oat-cell carcinoma of the lung. Lancet 1968; 2: 925-7. [CrossRef]
  • Shepherd FA, Ginsberg RJ, Evans WK, Feld R, Cooper JD, Ilves R, et al. Reduction in local recurrence and improved survival in surgically treated patients with small cell lung cancer. J Thorac Cardiovasc Surg 1983; 86: 498-506.
  • Shields TW, Higgins GA Jr, Matthews MJ, Keehn RJ. Surgical resection in the management of small cell carcinoma of the lung. J Thorac Cardiovasc Surg 1982; 84: 481-8.
  • Shepherd FA, Ginsberg RJ, Patterson GA, Evans WK, Feld R. A prospective study of adjuvant surgical resection after chemotherapy for limited small cell lung cancer. A University of Toronto Lung Oncology Group study. J Thorac Cardiovasc Surg 1989; 97: 177- 86.
  • Lucchi M, Mussi A, Chella A, Janni A, Ribechini A, Menconi GF, et al. Surgery in the management of small cell lung cancer. Eur J Cardiothorac Surg 1997; 12: 689-93. [CrossRef]
  • Rea F, Callegaro D, Favaretto A, Loy M, Paccagnella A, Fantoni U, et al. Long term results of surgery and chemotherapy in small cell lung cancer. Eur J Cardiothorac Surg 1998; 14: 398-402. [CrossRef]
  • de Hoyos A, DeCamp MM. Surgery for small cell lung cancer. Thorac Surg Clin 2014; 24: 399-409. [CrossRef]
  • Quoix E, Fraser R, Wolkove N, Finkelstein H, Kreisman H. Small cell lung cancer presenting as a solitary pulmonary nodule. Cancer 1990; 66: 577-82. [CrossRef]
  • Yang CJ, Chan DY, Shah SA, Yerokun BA, Wang XF, D’Amico TA, et al. Long-term Survival After Surgery Compared With Concurrent Chemoradiation for Node-negative Small Cell Lung Cancer. Ann Surg 2017. [CrossRef]
  • Lad T, Piantadosi S, Thomas P, Payne D, Ruckdeschel J, Giaccone G. A prospective randomized trial to determine the benefit of surgical resection of residual disease following response of small cell lung cancer to combination chemotherapy. Chest 1994; 106: 320-3. [CrossRef]
  • Pignon JP, Arriagada R, Ihde DC, Johnson DH, Perry MC, Souhami RL, et al. A meta-analysis of thoracic radiotherapy for small-cell lung cancer. N Engl J Med 1992; 327: 1618-24. [CrossRef]
  • Fujimori K, Yokoyama A, Kurita Y, Terashima M. A pilot phase 2 study of surgical treatment after induction chemotherapy for resectable stage I to IIIA small cell lung cancer. Chest 1997; 111: 1089-93. [CrossRef]
  • Brock MV, Hooker CM, Syphard JE, Westra W, Xu L, Alberg AJ, et al. Surgical resection of limited disease small cell lung cancer in the new era of platinum chemotherapy: Its time has come. J Thorac Cardiovasc Surg 2005;129: 64-72. [CrossRef]
  • Badzio A, Kurowski K, Karnicka-Mlodkowska H, Jassem J. A retrospective comparative study of surgery followed by chemotherapy vs. non-surgical management in limited-disease small cell lung cancer. Eur J Cardiothorac Surg 2004; 26: 183-8. [CrossRef]
  • Schreiber D, Rineer J, Weedon J, Vongtama D, Wortham A, Kim A, et al. Survival outcomes with the use of surgery in limited-stage small cell lung cancer: should its role be re-evaluated? Cancer 2010; 116: 1350-7. [CrossRef]
  • Takenaka T, Takenoyama M, Inamasu E, Yoshida T, Toyokawa G, Nosaki K, et al. Role of surgical resection for patients with limited disease-small cell lung cancer. Lung Cancer 2015; 88: 52-6. [CrossRef]
  • Stish BJ, Hallemeier CL, Olivier KR, Harmsen WS, Allen MS, Garces YI. Long-Term Outcomes and Patterns of Failure After Surgical Resection of Small-Cell Lung Cancer. Clin Lung Cancer 2015; 16: 67-73. [CrossRef]
  • Weksler B, Nason KS, Shende M, Landreneau RJ, Pennathur A. Surgical resection should be considered for stage I and II small cell carcinoma of the lung. Ann Thorac Surg 2012; 94: 889-93. [CrossRef]
  • Combs SE, Hancock JG, Boffa DJ, Decker RH, Detterbeck FC, Kim AW. Bolstering the case for lobectomy in stages I, II, and IIIA small-cell lung cancer using the National Cancer Data Base. J Thorac Oncol 2015; 10: 316-23. [CrossRef]
  • Takei H, Kondo H, Miyaoka E, Asamura H, Yoshino I, Date H, et al. Surgery for small cell lung cancer: a retrospective analysis of 243 patients from Japanese Lung Cancer Registry in 2004. J Thorac Oncol 2014; 9: 1140-5. [CrossRef]
  • Varlotto JM, Recht A, Flickinger JC, Medford-Davis LN, Dyer AM, DeCamp MM. Lobectomy leads to optimal survival in early-stage small cell lung cancer: a retrospective analysis. J Thorac Cardiovasc Surg 2011; 142: 538-46. [CrossRef]
  • Xu YJ, Zheng H, Gao W, Jiang GN, Xie HK, Chen C, et al. Is neoadjuvant chemotherapy mandatory for limited-disease small-cell lung cancer? Interact Cardiovasc Thorac Surg 2014; 19: 887-93. [CrossRef]
  • Jett JR, Schild SE, Kesler KA, Kalemkerian GP. Treatment of small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013; 143: 400-19. [CrossRef]
  • Rudin CM, Ismaila N, Hann CL, Malhotra N, Movsas B, Norris K, et al. Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline. J Clin Oncol. 2015; 33: 4106-11. [CrossRef]
  • Yang CJ, Chan DY, Speicher PJ, Gulack BC, Tong BC, Hartwig MG, et al. Surgery Versus Optimal Medical Management for N1 Small Cell Lung Cancer. Ann Thorac Surg 2017; 103: 1767-72. [CrossRef]
  • Granetzny A, Boseila A, Wagner W, Krukemeyer G, Vogt U, Hecker E, et al. Surgery in the tri-modality treatment of small cell lung cancer. Stage-dependent survival. Eur J Cardiothorac Surg 2006; 30: 212-6. [CrossRef]
  • Eberhardt W, Korfee S. New approaches for small-cell lung cancer: local treatments. Cancer Control 2003; 10: 289-96. [CrossRef]
  • Rostad H, Naalsund A, Jacobsen R, Strand TE, Scott H, Heyerdahl Strom E, et al. Small cell lung cancer in Norway. Should more patients have been offered surgical therapy? Eur J Cardiothorac Surg 2004; 26: 782-6. [CrossRef]
  • Tsuchiya R, Suzuki K, Ichinose Y, Watanabe Y, Yasumitsu T, Ishizuka N, et al. Phase II trial of postoperative adjuvant cisplatin and etoposide in patients with completely resected stage I-IIIa small cell lung cancer: the Japan Clinical Oncology Lung Cancer Study Group Trial (JCOG9101). J Thorac Cardiovasc Surg 2005; 129: 977-83. [CrossRef]
  • Bischof M, Debus J, Herfarth K, Muley T, Kappes J, Storz K, et al. Surgery and chemotherapy for small cell lung cancer in stages I-II with or without radiotherapy. Strahlenther Onkol 2007; 183: 679-84. [CrossRef]
  • Lim E, Belcher E, Yap YK, Nicholson AG, Goldstraw P. The role of surgery in the treatment of limited disease small cell lung cancer: time to reevaluate. J Thorac Oncol. 2008; 3: 1267-71. [CrossRef]
European Journal of Therapeutics-Cover
  • ISSN: 2564-7784
  • Başlangıç: 1990
  • Yayıncı: Fatma Taşçı
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