The Philosophy of Staging in Lung Cancer: Prognosis or Treatment Planning?
The Philosophy of Staging in Lung Cancer: Prognosis or Treatment Planning?
Tumor staging is one of the cornerstones of oncology. The purpose of staging is to provide a universal terminology regardingthe anatomical extent of cancer without causing incomprehensibility. This allows for reliable communication between clinicianswithout room for doubt, a common language in clinical studies, and the evaluation of the results of planned treatment strategies.Although it is critical to represent staging with a terminology that is used consistently and coherently, periodic revisions are alsonecessary. The terminology is also improved in parallel with the obtainment of new data regarding the definition of the anatomicalextent of tumors with developments in technology. Although the American Joint Committee on Cancer (AJCC) and the InternationalUnion for Cancer Control (UICC) are institutions that define and periodically review the classification systems and work togetherin order to ensure the universal consistency of staging, staging in thorax malignancies has been regulated under the lead ofthe International Association for the Study of Lung Cancer (IASLC) for the last two decades. The aim of this review is to summarizeand discuss the philosophy of staging in lung cancer.
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- Edge SB, Byrd DR, Carducci MA, Compton CC, Fritz AG, Greene FL,
Trotti A, editors. AJCC Cancer Staging Manual. 7th ed. New York:
Springer; 2010.
- Detterbeck FC, Boffa DJ, Kim AW, Tanoue LT. The Eighth Edition Lung
Cancer Stage Classification. Chest 2017; 151: 193-203. [CrossRef]
- Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta
R, et al. The IASLC Lung Cancer Staging Project: proposals for the
revision of the TNM stage groupings in the forthcoming (seventh)
edition of the TNM classification of malignant tumours. J Thorac Oncol
2007; 2: 706-14. [CrossRef]
- Rami-Porta R, Asamura H, Brierley J, Goldstraw P. Staging, Tumor
Profile, and Prognostic Groups in Lung Cancer or the New Tower of
Babel. Journal Thorac Oncol 2016; 11: 1201-3. [CrossRef]
- Chansky K, Sculier JP, Crowley JJ, Giroux D, Van Meerbeeck J, Goldstraw
P. The International Association for the Study of Lung Cancer
Staging Project: prognostic factors and pathologic TNM stage in
surgically managed non-small cell lung cancer. J Thorac Oncol 2009;
4: 792-801. [CrossRef]
- Halsted WS. The results of radical Operations for the Cure of Carcinoma
of the Breast. Ann Surg 1907; 46: 1-19. [CrossRef]
- Burke HB. Outcome Prediction and the Future of the TNM Staging
System. Journal of the National Cancer Institute, 2004; 96: 1408-9.
[CrossRef]
- Burke HB, Henson DE. Criteria for prognostic factors and for an enhanced
prognostic system. Cancer 1993: 72; 3131-5.
- Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt
WE, et al. The IASLC Lung Cancer Staging Project: proposals
for revision of the TNM stage groupings in the forthcoming (eighth)
edition of the TNM classification for lung cancer. J Thorac Oncol
2016; 11: 39-51. [CrossRef]
- Asamura H, Chansky K, Crowley J, Goldstraw P, Rusch VW,
Vansteenkiste JF, et al. The International Association for the Study
of Lung Cancer Lung Cancer Staging Project: Proposals for the Revision
of the N Descriptors in the Forthcoming 8th Edition of the
TNM Classification for Lung Cancer. J Thorac Oncol 2015; 10: 1675-
84. [CrossRef ]
- Eberhardt WE, Mitchell A, Crowley J, Kondo H, Kim YT, Turrisi A I, et
al. The IASLC Lung Cancer Staging Project: Proposals for the Revision
of the M Descriptors in the Forthcoming Eighth Edition of the
TNM Classification of Lung Cancer. J Thorac Oncol 2015; 10: 1515-
22. [CrossRef]